Abstract: The invention relates to benzimidazoles of Formula (I) and pharmaceutically acceptable salts thereof, wherein R1 to R6 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: An information handling system includes a bottom case and a wireless charging puck. The bottom case includes a bay. The wireless charging puck fits into the bay, and is detachable from the bottom case. When the wireless charging puck is fitted into the bay, the wireless charging puck is configured as a power receiving unit to receive wireless power. When the wireless charging puck is detached from the bay, the wireless charging puck is configured as a power transmitting unit to provide wireless power to an external device.

Abstract: The invention relates to imidazopyridines of Formula (I) and pharmaceutically acceptable salts thereof, wherein R0 to R5 are as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The benzimidazoles of Formula (I) are ITK inhibitors and are therefore potentially useful in the treatment of a wide range of disorders including, atopic dermatitis.

Abstract: Described are effervescent dissolvable solid structures comprising effervescent agglomerated particles which enhance the consumer experience and can improve dissolution of the structure. Also described are processes for the Dissolvable Solid Structure comprising effervescent agglomerated particles. Also described are methods for making the effervescent agglomerated particle.

Abstract: A system and method for voice control of a media playback device is disclosed. The method includes receiving an instruction of a voice command, converting the voice command to text, transmitting the text command to the playback device, and having the playback device execute the command. An instruction may include a command to play a set of audio tracks, and the media playback device plays the set of audio tracks upon receiving the instruction.

Abstract: Beamforming for adapting wireless signaling beams in an adaptive and agile manner is contemplated. The beamforming may be characterized by adaptively constructing beam form parameters to provide wireless signaling in a manner that maximizes efficiency and bandwidth according to device positioning relative to a responding base station.

Abstract: A system and method for voice control of a media playback device is disclosed. The method includes receiving an instruction of a voice command, converting the voice command to text, transmitting the text command to the playback device, and having the playback device execute the command. An instruction may include a command to play a set of audio tracks, and the media playback device plays the set of audio tracks upon receiving the instruction.

Abstract: The disclosure relates to improvements in methods for efficient editing of two or more endogenous tomato genes by insertion of one or more single stranded DNA donor molecules that are not homologous to the insertion sites in the tomato genome.

Abstract: A water-soluble pouch for hair care with a water-soluble fibrous facing sheet and a water-soluble backing sheet. The facing sheet and backing sheet are joined by a seal along at least a portion of the perimeter. A plurality of hair conditioner prills are disposed within the internal volume. The prills can include both cationic surfactant and fatty alcohol and can have a melting point greater than 45°.

Abstract: Methods for generating a vocal signature for a user and performing speaker verification on a device. The method comprises: receiving a vocal sample from a user; extracting a feature vector describing characteristics of the user’s voice from the vocal sample; and processing the feature vector using a trained neural network, wherein the processing comprises: inputting elements of the feature vector to a first convolutional layer; operating on the inputted elements with the first convolutional layer; performing max pooling using a first max pooling layer; operating on the activations of the first max pooling layer with a second convolutional layer; performing max pooling using a second max pooling layer; inputting activations of the second max pooling layer to a statistics pooling layer; and inputting activations of the statistics pooling layer to a fully-connected layer; extracting the activations of the fully-connected layer; and generating a vocal signature for the user.

Abstract: A method of generating a biometric signature of a user for use in authentication using a neural network, the method comprising: receiving (110) a plurality of biometric samples from a user; extracting at least one feature vector using the plurality of biometric samples; using the elements of the at least one feature vector as inputs for a neural network; extracting the corresponding activations from an output layer of the neural network; and generating a biometric signature of the user using the extracted activations, such that a single biometric signature represents multiple biometric samples from the user.

Abstract: A diaphragm pump mechanism is powered by steam generated by an internal heater coil heating the pumped water, which moves the diaphragm and an attached piston to pump water through the pump. The heater coil is turned on-and-off using a switch that is timed to the movement of the pump. The water is pumped through a series of one-way rubber valves and reed valves to prevent a back flow of water. The pressure generated by the steam is released when a reed valve located on the diaphragm makes contact with a pin located on the body of the pump, opening the reed valve and allowing the steam to travel through and to condense. The piston and diaphragm are returned to the starting position when the steam pressure is released by a spring attached to the pump shaft. On the return stroke an accumulator refills the diaphragm chamber with water.

Abstract: A diaphragm pump mechanism is powered by steam generated by an internal heater coil heating the pumped water, which moves the diaphragm and an attached piston to pump water through the pump. The heater coil is turned on-and-off using a switch that is timed to the movement of the pump. The water is pumped through a series of one-way rubber valves and reed valves to prevent a back flow of water. The pressure generated by the steam is released when a reed valve located on the diaphragm makes contact with a pin located on the body of the pump, opening the reed valve and allowing the steam to travel through and to condense. The piston and diaphragm are returned to the starting position when the steam pressure is released by a spring attached to the pump shaft. On the return stroke an accumulator refills the diaphragm chamber with water.

Abstract: The present invention is a reliable, lightweight, environmentally friendly, highly reusable, highly durable, fully collapsible container for use in transporting solid and liquid materials, including those materials governed by the dangerous goods code of the UN regulations. The container employs a selectively sealed lid, a truss system for preventing bulge at the rim of the container so that the rim remains within the footprint of the lid, and an integrated closure system for securing transported contents.

Abstract: Bioconjugates for use in imaging are disclosed include a linker sequence fused to a polypeptide capable of binding a target in a biological system. The linker sequence is designed so that it is capable of being radiolabelled, e.g. with a complex comprising a radionuclide, via a free cysteine residue and the polyhistidine sequence in the label that are both capable of simultaneously binding to a complex comprising the radionuclide. These interactions can improve significantly the rate and efficiency of radiolabelling compared to either protein with the His-tag or the free cysteine alone. Optionally, the free cysteine residue provides a site which can be covalently bonded to a moiety such as a second label, in a site-specific manner.

Abstract: A robotic tool changer and systems and methods for controlling the operation of a robotic tool changer are provided. The tool changer, methods, and systems include a robot-side component mountable to a robot arm end interface; a tool-side component adapted to engage a tool; a first slave module associated with the robot-side component and adapted to communicate with a first master module; and a second master module associated with the robot-side component and adapted to communicate with a second slave module associated with the tool. The second slave module may include a temporary power supply, for example, a battery or a capacitor, for instance, a super capacitor. Aspects of the invention are advantageous for performing high-speed robotic connections and disconnections, and for providing tool and tool changer performance information gathering.

Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.

Abstract: The present invention provides compounds, compositions and methods for the selective inhibition of cathepsin S. In a preferred aspect, cathepsin S is selectively inhibited in the presence of at least one other cathepsin isozyme (e.g., cathespin K). The present invention also provides methods for treating a disease state in a subject by selectively inhibiting cathepsin S.