Abstract: A method of increasing the hydrophilicity of a polymer surface, such as a contact lens surface, includes exposing the polymer substrate to a first plasma under conditions selected to generate free radicals on the surface of the polymer substrate. The method also includes reacting an organic compound with the free radicals on the surface of the polymer substrate to thereby form an organic coating. The method further includes exposing the organic coating to a second plasma under conditions selected to oxidize the organic coating to thereby form a hydrophilic layer at the substrate surface. The hydrophilic layer can have a contact angle with respect to water that is less than about 50°.

Abstract: A hybrid contact lens includes a substantially rigid center portion and a substantially flexible skirt portion connected to the center portion. The skirt portion is formed using xerogels compatible with diluents comprising at least one selected from polylactic acid, polyglycolic acid, lactide, glycolide, a polyacetal, a cyclic acetal, a polyketal, a cyclic ketal, a polyorthoester, a cyclic orthoester, di-t-butyl-dicarbonate, tris(trimethylsilyl)amine, and 2,2,2-trifluoroacetamide. These diluents are formulated to function as a stand-in for water in the xerogel polymer, allowing the xerogel to form and bond to the rigid center portion in its fully expanded state. Upon hydration of the hybrid lens, substantially little dimensional change, and thus substantially little distortion, is obtained in the skirt portion.

Abstract: Contact lenses which exhibit improved wetability are provided. In one aspect, the surface of the contact lenses may be modified using a hydrophilic layer which imparts improved wetability to the contact lens. The contact lens may be exposed to a first plasma so as to generate free radicals on the contact lens surface. An organic compound may be further reacted with the free radicals on the surface to form an organic coating. The contact lens may be exposed to a under conditions selected to oxidize the organic coating and form the hydrophilic layer. Surface modified contact lenses may exhibit contact angles with respect to water less than about 50° using a broad range of organic compounds, including alcohols, ethers, aldehydes, ketones, esters, organosilicon, organophosphorous, organotitanium, organotin, organogermanium, and organoboron compounds. The improved wetability is also substantially maintained when the lens is subject to wear.

Abstract: A hybrid contact lens includes a substantially rigid center portion and a substantially flexible skirt portion connected to the center portion. The skirt portion is formed using xerogels compatible with diluents comprising at least one selected from polylactic acid, polyglycolic acid, lactide, glycolide, a polyacetal, a cyclic acetal, a polyketal, a cyclic ketal, a polyorthoester, a cyclic orthoester, di-t-butyl-dicarbonate, tris(trimethylsilyl)amine, and 2,2,2-trifluoroacetamide. These diluents are formulated to function as a stand-in for water in the xerogel polymer, allowing the xerogel to form and bond to the rigid center portion in its fully expanded state. Upon hydration of the hybrid lens, substantially little dimensional change, and thus substantially little distortion, is obtained in the skirt portion.