Patents by Inventor Jeno Szilbereky
Jeno Szilbereky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9381213Abstract: The invention relates to a novel antiviral and immune-simulating pharmaceutical composition, containing as active ingredient 20-85 mass % of a ?-3-polyunsaturated fatty acid ester, in fish oil concentrate containing 20-70 mass % of a 5,8,11,14,17-eicosapentaenic acid ester and a 4,7,10,13,16,19-docosahexaenic acid ester, further 1-lysine of a salt thereof, optionally a zinc salt, selenium or a selenium compound, as well as additives and carrier ingredients.Type: GrantFiled: November 15, 2005Date of Patent: July 5, 2016Assignee: SINNEX MUSZAKI FEJLESZTO ES TANACSADO KFTInventors: Jenö Szilbereky, Andrea Jednákovits, Ernöné Koltai, Gyula Orbán, Katalin Bíró
-
Publication number: 20150272189Abstract: Disclosed is a novel process for the preparation of novel raw material for functional foods containing bioactive materials, comprising activating the enzymes of edible plant seeds at a temperature of 10-35° C. for a period of 5-72 hours with oxygen and water until reaching the maximum nutritional value of the seeds, then the seeds together with their sprouts are treated in the aqueous solution or suspension or emulsion of physiologically or dietetically advantageous materials between 60-100° C. for a period of 10-180 minutes, and then the raw material containing the physiologically important biological materials in this enhanced concentration is separated, dried, optionally chopped and packed. The invention also relates to the products of the novel preparation process and their use.Type: ApplicationFiled: October 16, 2013Publication date: October 1, 2015Applicant: FITOREX KFT.Inventors: Jeno Szilbereky, Andrea Jednakovits, Andras Salgo, Gabor Barla Szabo, Laszlo Szabados
-
Publication number: 20110223313Abstract: A soya bean product with improved effect, wherein stachyose content is smaller than 7.0 mg/g dry matter and vitamin E (tocopherols, tocotrienols) content is higher than 3.0 mg/g dry matter. A method of producing the soya bean product is described.Type: ApplicationFiled: November 3, 2009Publication date: September 15, 2011Applicant: FITOREX GROUP KFT.Inventors: Andrea Jednakovits, Andras Salgo, Jeno Szilbereky, Gabor Barka Szabo, Gaborne Barla Szabo
-
Publication number: 20100267711Abstract: A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.Type: ApplicationFiled: June 25, 2010Publication date: October 21, 2010Applicant: CytRx CorporationInventors: László Vígh, Péter Literáti Nagy, Jenó Szilbereky, László Ürögdi, Andrea Jednákovits, László Jaszlits, Katalin Bíró, Ede Màrvànyos, Mihály Barabás, Erzsébet Hegedüs, László Korányi, Mária Kürthy, Gábor Balogh, Ibolya Horváth, Zsolt Török, Éva Udvardy, György Dormán, Dénes Medzihradszky, Bea Mézes, Eszter Kovács, Ernó Duda, Beatrix Farkas, Attila Glatz
-
Patent number: 7745465Abstract: A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.Type: GrantFiled: July 10, 2003Date of Patent: June 29, 2010Assignee: CytRx CorporationInventors: László Vígh, Péter Literáti Nagy, Jenö Szilbereky, László Ürögdi, Andrea Jednákovits, László Jaszlits, Katalin Bíró, Ede Márványos, Mihály Barabás, Erzsébet Hegedüs, László Korányi, Mária Kürthy, Gábor Balogh, Ibolya Horváth, Zsolt Török, Éva Udvardy, György Dormán, Dénes Medzihradszky, Bea Mézes, Eszter Kovács, Ernö Duda, Beatrix Farkas, Attila Glatz
-
Publication number: 20080131519Abstract: The invention relates to a novel antiviral and immune-simulating pharmaceutical composition, containing as active ingredient 20-85 mass % of a ?-3-polyunsaturated fatty acid ester, in fish oil concentrate containing 20-70 mass % of a 5,8,11,14,17-eicosapentaenic acid ester and a 4,7,10,13,16,19-docosahexaenic acid ester, further 1-lysine of a salt thereof, optionally a zinc salt, selenium or a selenium compound, as well as additives and carrier ingredients.Type: ApplicationFiled: November 15, 2005Publication date: June 5, 2008Applicant: SINNEX MUSZAKI FEJILESZTO ES TANACSADO KFTInventors: Jeno Szilbereky, Andrea Jednakovits, Ernone Koltai, Gyula Orban, Katalin Biro
-
Patent number: 7148239Abstract: A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.Type: GrantFiled: July 10, 2003Date of Patent: December 12, 2006Assignee: CytRx CorporationInventors: László Vígh, Péter Literáti Nagy, Jenó Szilbereky, László Ürögdi, Andrea Jednákovits, László Jaszlits, Katalin Bíró, Ede Márványos, Mihály Barabás, Erzsébet Hegedüs, László Korányi, Mária Kürthy, Gábor Balogh, Ibolya Horváth, Zsolt Török, Éva Udvardy, György Dormán, Dénes Medzihradszky, Bea Mézes, Eszter Kovács, Ernó Duda, Beatrix Farkas, Attila Glatz
-
Publication number: 20040067940Abstract: A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxylamine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.Type: ApplicationFiled: July 10, 2003Publication date: April 8, 2004Applicant: Biorex Research & Development Co.Inventors: Laszlo Vigh, Peter Literati Nagy, Jeno Szilbereky, Laszlo Urogdi, Andrea Jednakovits, Laszlo Jaszlits, Katalin Biro, Ede Marvanyos, Mihaly Barabas, Erzsebet Hegedus, Laszlo Koranyi, Maria Kurthy, Gabor Balogh, Ibolya Horvath, Zsolt Torok, Eva Udvardy, Gyorgy Dorman, Denes Medzihradszky, Bea Mezes, Eszter Kovacs, Erno Duda, Beatrix Farkas, Attila Glatz
-
Publication number: 20040019103Abstract: A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively, an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II).Type: ApplicationFiled: July 10, 2003Publication date: January 29, 2004Applicant: Biorex Research & Development Co.Inventors: Laszlo Vigh, Peter Literati Nagy, Jeno Szilbereky, Laszlo Urogdi, Andrea Jednakovits, Laszlo Jaszlits, Katalin Biro, Ede Marvanyos, Mihaly Barabas, Erzsebet Hegedus, Laszlo Koranyi, Maria Kurthy, Gabor Balogh, Ibolya Horvath, Zsolt Torok, Eva Udvardy, Gyorgy Dorman, Denes Medzihradszky, Bea Mezes, Eszter Kovacs, Erno Duda, Beatrix Farkas, Attila Glatz
-
Patent number: 6653326Abstract: A method of increasing expression of a molecular chaperon by a cell and/or enhancing the activity of a molecular chaperon in cells is provided. The method comprises treating a cell that is exposed to a physiological stress which induces expression of a molecular chaperon by the cell with an effective amount of a certain hydroxylamine derivative to increase the stress. Alternatively; an hydroxylamine derivative can be administrated to a cell before it is exposed to a physiological stress which induces expression of a molecular chaperon by the cell. Preferably, the cell to which an hydroxylamine derivative is administered is an eukaryotic cell. The hydroxylamine derivative corresponds to the formulae (I) or (II). The invention also provides novel hydroxyl amine derivatives falling within the scope of the formulae (I) and (II) as well as pharmaceutical and/or cosmetical compositions comprising the said compounds.Type: GrantFiled: December 7, 1999Date of Patent: November 25, 2003Assignee: Biorex Research & Development Co.Inventors: László Vígh, Péter Literáti Nagy, Jenó Szilbereky, László Ürögdi, Andrea Jednákovits, László Jaszlits, Katalin Bíró, Ede Màrvànyos, Mihály Barabás, Erzsébet Hegedüs, László Korányi, Mária Kürthy, Gábor Balogh, Ibolya Horváth, Zsolt Török, Éva Udvardy, György Dormán, Dénes Medzihradszky, Bea Mézes, Eszter Kovács, Ernö Duda, Beatrix Farkas, Attila Glatz
-
Patent number: 6649628Abstract: N-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride, its stereoisomers, and the addition salts thereof, pharmaceutical compositions containing the same, methods of treating pathological insulin resistance, methods of treating pathological insulin resistance and pathological conditions associated therewith, and methods of treating pathological insulin resistance by simultaneously treating diabetes-induced chronic complications, especially retinopathy, neuropathy and nephropathy, and/or by simultaneously increasing pathologically decreased peripheral neuroregeneration caused by diabetes.Type: GrantFiled: December 18, 2001Date of Patent: November 18, 2003Assignee: Biorex Kutato es Fejleszto RTInventors: Maria Kürthy, Katalin Bíró, Károly Nagy, László Ürögdi, Zita Csákai, Jenö Szilbereky, Tamás Mogyorósi, Magdolna Török, András Komáromi, Ede Márványos, Mihály Barabás, Mihályné Kardos, Zoltán Nagy, László Korányi, Melinda Nagy
-
Patent number: 6384029Abstract: The invention relates to (−)-5,6-dihydro-5-(1-piperidinyl)-methyl-3-(3-pyridyl)-4H-1,2,4-oxadiazine to the therapeutical use thereof and to phamaceutical compositions containing the compounds as active ingredient.Type: GrantFiled: May 15, 2001Date of Patent: May 7, 2002Assignee: Biorex Kutató Fejlesztö RT.Inventors: Andrea Jednákovits, Lászió Ürögdi, Lászió Dénes, István Kurucz, Ede Márványos, Mihály Barabás, Ernö Bácsy, Zsuzsanna Korom, Zoltán Nagy, László Ürge, Jenö Szilbereky, Károly Acsai, Péter Krajcsi, Zita Csákai, Magdolna Török
-
Publication number: 20010051630Abstract: This invention relates to the use of hydroxylamine derivatives of general formula (I), wherein R1 represents phenyl, N-heteroaryl, S-heteroaryl or a naphthyl group any of which may be unsubstituted or substituted, an unsubstituted or substituted phenylamino or alkylamino or lower alkoxy; X represents halo, amino or an unsubstituted or substituted phenylamino group, or amino substituted with one or two lower alkyl or a hydroxy group, provided that if R1 represents unsubstituted or substituted phenylamino, alkylamino or lower alkoxy, then X is not halo; Y represents hydrogen, hydroxy or alkanoyloxy, with the proviso that simultaneously R1 may not represent phenyl, halophenyl, alkoxyphenyl, N-heteroaryl or naphthyl, X may not represent halo, hydroxy or amino and Y may not represent hydrogen or hydroxy; R2 and R3, independently from each other, represent hydrogen or lower alkyl group, provided that R2 and R3 are not hydrogen simultaneously, or R2 and R3 along with the adjacent nitrogen atom form a 5- to 7-membereType: ApplicationFiled: January 10, 2001Publication date: December 13, 2001Inventors: Andrea Jednakovits, Gabor Galiba, Laszlo Urogdi, Jeno Szilbereky, Ede Marvanyos, Gabor Kocsy, Laszlo Stehly, Tamas Berzy, Mihaly Barabas, Zita Csakai, Magdolna Torok
-
Patent number: 5328906Abstract: Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.Type: GrantFiled: June 7, 1993Date of Patent: July 12, 1994Assignee: Biorex Kutato-Fejleszto KFTInventors: Peter L. Nagy, Bela Balazs, Maria Boross, Jeno Szilbereky, Gizella Zsila, Lajos Abraham, Gyorgy Blasko, Bela Gachalyi, Attila Almasi, Gabor Nemet
-
Patent number: 5296606Abstract: Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.Type: GrantFiled: July 1, 1992Date of Patent: March 22, 1994Assignee: Biorex Kutato-Fejleszto KFTInventors: Peter L. Nagy, Bela Balazs, Maria Boross, Jeno Szilbereky, Gizella Zsila, Lajos braham, Gyorgy Blasko, Bela Gachalyi, Attila Almasi, Gabor Nemet
-
Patent number: 5216023Abstract: The compounds of the Formula (I) ##STR1## wherein R.sub.1 is a C.sub.18-24 alkenyl containing at least two double bonds, or --(CH2)n --CH(NH2)m --COOHX is 0, NH or C.sub.1-4 alkyl-N,Y is CONH.sub.2, COOH or COOMe, wherein Me is hydrogen metal, andR.sub.2 is a side chain of a any amino acid except L-GLU or L-ASP at .alpha.-position or a group of Formula--(CH.sub.2).sub.k --C.sub.6 H.sub.3 --(A).sub.2 (II),--(CH.sub.2).sub.n --X--(CH.sub.2).sub.m --X--M (III)whereink is zero or an integer of 1,n is zero or an integer of 1 to 3,m is zero or an integer of 1 to 4,A is hydroxyl or one A is hydroxyl and the other A is hydrogen.M is H or R.sub.1 --CO andX and R.sub.1 are as defined aboveand their salts having tyrosine kinase inhibitor activity can be used as antitumor agents.Type: GrantFiled: September 12, 1990Date of Patent: June 1, 1993Assignee: Folligen Budapest Ltd.Inventors: Peter N. Literati, Gyorgy Keri, Maria Boross, Gabor Nemeth, Jeno Szilbereky, Ildiko Szilagyi
-
Patent number: 5147879Abstract: Hydroximic acid derivatives of the formula ##STR1## These compounds are useful for treating diabetes angiopathy.Type: GrantFiled: June 28, 1990Date of Patent: September 15, 1992Assignee: Biorex Kutato-Fejleszto KftInventors: Peter L. Nagy, Bela Balazs, Maria Boross, Jeno Szilbereky, Gizella Zsila, Lajos braham, Gyorgy Blasko, Bela Gachalyi, Attila Almasi, Gabor Nemet
-
Patent number: 5137605Abstract: A process for the dehydration of substances, mixtures, primarily condensation reaction mixtures, (e.g. direct esterification, direct acetal formation, direct ketal formation), performed by continuous azeotropic distillation with an organic solvent forming with water an azeotropic mixture of minimal boiling point and unable to mix with water, carried out in such a way that the distillate is cooled at least to the temperature, at which the condensate with the given water content or the organic phase of the condensate is just supersaturated with respect to water, and the organic phase of lower water content obtained in this way is recycled to the distilling boiler. The organic solvents used are e.g. benzene, toluene, 1,2-dichloroethane, chloroform, carbon tetrachloride.Type: GrantFiled: October 15, 1990Date of Patent: August 11, 1992Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Istvan Greiner, Jeno Szilbereky, Bela Stefko, Gyorgy Thaler
-
Patent number: 4985463Abstract: An antifungal or anthelmintic method of treatment is disclosed which comprises the step of administering to a mammal in need of said treatment, a pharmaceutically effective amount of a compound of the Formula (I) ##STR1## wherein X is halogen, C.sub.1 to C.sub.6 alkoxy, or a group --NRR.sup.1 in which R and R.sup.1 are each hydrogen or C.sub.1 to C.sub.6 alkyl; andR.sup.2 is hydrogen, halogen, C.sub.1 to C.sub.6 alkyl, C.sub.1 to C.sub.6 alkoxy, phenyl, phenylthio, or phenyl or phenylthio substituted by at least one halogen or amino substituent; or a pharmaceutically acceptable acid addition salt thereof.Type: GrantFiled: February 28, 1985Date of Patent: January 15, 1991Assignee: Richter Gedeon Vegyeszeti Gyar RtInventors: Janos Kreidl, Peter Turcsanyi, Zsuzsanna Arcs nee Trischler, Bela Stefko, Judit M. Meszaros nee Brill, Ida Deutsch nee Juhasz, Jeno Szilbereky, Eva Csizer, Szilard Vezer
-
Patent number: 4831194Abstract: The invention relates to a new process for the preparation of aminodiaryl sulfoxide derivatives of the formula (I), ##STR1## wherein X is halogen, alkoxy having from 1 to 6 carbon atoms or a group --(N,R,R.sup.1), in which p1 R and R.sup.1 are hydrogen or alkyl having from 1 to 6 carbon atoms,R.sup.2 is hydrogen, halogen, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms or phenyl or phenylthio both optionally substituted by one or more identical or different halogen(s) and/or amino group(s),and acid addition salts thereof.The compounds of formula (I) are pharmaceutically active, in particular are potent anthelmintics, or can be used as active ingredients in pesticidal compositions. The invention therefore relates to pharmaceutical and pesticidal compositions containing compounds of formula (I) or salts thereof as active ingredient.Compounds of formula (I), in which the substituents are as defined above, but if X stands for a group --N(R,R.sup.1) in which R and R.sup.Type: GrantFiled: July 23, 1987Date of Patent: May 16, 1989Assignee: Richter Gedeon Vegyeszeti Gyar Rt.Inventors: Janos Kreidl, Peter Turcsanyi, Zsuzsanna Aracs nee Trischler, Bela Stefko, Judit Meszaros nee Brill, Ida Deutsch nee Juhasz, Jeno Szilbereky, Eva Csizer, Szilard Vezer, Erik Bogsch, Jozsef Bakos, Laszlo Szotyori, Balint Heil