Patents by Inventor Jens Altrichter
Jens Altrichter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230225939Abstract: The present invention, inter alia, relates to a closed sterilized container comprising at least one carrier which is a stabilizer; and at least one biomolecule reversibly attached to the carrier, wherein said carrier partially or completely covers the attached biomolecules and wherein said at least one carrier is selected from the group consisting of (poly)peptides such as dipeptides or tripeptides, amino acids, polyalcohols, polyethyleneglycols, ionic liquids, compatible solutes, saponins and a mixture thereof. The invention also relates to methods for producing sterilized containers according to the invention and uses thereof.Type: ApplicationFiled: January 18, 2023Publication date: July 20, 2023Applicant: Leukocare AGInventors: Jens Altrichter, Anja Breuer, Nicole Schaath, Julia Quathamer
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Publication number: 20230165793Abstract: The present invention relates to a method of producing low viscous and highly concentrated biopharmaceutical drug products comprising a biomolecule of interest, the method comprising: (a) a first phase of preparing a drug substance of the biomolecule of interest, said first phase comprising at least one processing step selected from (a1) harvesting, (a2) purification, (a3) re-buffering, and (a4) enrichment, wherein said at least one processing step in this first phase is carried out in the presence of a composition comprising at least three amino acids, wherein the combination of said at least three amino acids provides at least one positively charged functional group, at least one anti-oxidative functional group, at least one osmolytic function, and at least one buffering function, and (b) a second phase of further processing the drug substance prepared in (a) to obtain a low viscous and highly concentrated biopharmaceutical drug product, said second phase comprising at least one processing step selected froType: ApplicationFiled: November 21, 2022Publication date: June 1, 2023Applicant: Leukocare AGInventors: Martin Scholz, Kristina Kemter, Jens Altrichter, Thomas Kriehuber
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Patent number: 11564865Abstract: The present invention, inter alia, relates to a closed sterilized container comprising at least one carrier which is a stabilizer; and at least one biomolecule reversibly attached to the carrier, wherein said carrier partially or completely covers the attached biomolecules and wherein said at least one carrier is selected from the group consisting of (poly)peptides such as dipeptides or tripeptides, amino acids, polyalcohols, polyethyleneglycols, ionic liquids, compatible solutes, saponins and a mixture thereof. The invention also relates to methods for producing sterilized containers according to the invention and uses thereof.Type: GrantFiled: January 16, 2014Date of Patent: January 31, 2023Assignee: Leukocare AGInventors: Jens Altrichter, Anja Breuer, Nicole Schaath, Julia Quathamer
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Patent number: 11510871Abstract: The present invention relates to a method of producing low viscous and highly concentrated biopharmaceutical drug products comprising a biomolecule of interest, the method comprising: (a) a first phase of preparing a drug substance of the biomolecule of interest, said first phase comprising at least one processing step selected from (a1) harvesting, (a2) purification, (a3) re-buffering, and (a4) enrichment, wherein said at least one processing step in this first phase is carried out in the presence of a composition comprising at least three amino acids, wherein the combination of said at least three amino acids provides at least one positively charged functional group, at least one anti-oxidative functional group, at least one osmolytic function, and at least one buffering function, and (b) a second phase of further processing the drug substance prepared in (a) to obtain a low viscous and highly concentrated biopharmaceutical drug product, said second phase comprising at least one processing step selected froType: GrantFiled: September 15, 2017Date of Patent: November 29, 2022Assignee: Leukocare AGInventors: Martin Scholz, Kristina Kemter, Jens Altrichter, Thomas Kriehuber
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METHOD FOR OBTAINING EFFICIENT COMPOSITIONS COMPRISING VIRAL VECTORS FOR VACCINATION OR GENE THERAPY
Publication number: 20220325250Abstract: The present invention relates to a method for preparing a composition comprising a viral vector, the method comprising the steps of a) providing viral vectors, (b) providing a solution comprising at least one sugar and at least three different excipients selected from hydrophilic and amphiphilic excipients, wherein the excipients are characterized by polar, aliphatic, aromatic, negatively charged, and/or positively charged functional groups, and wherein the solution is free or substantially free of Mg2+ or of any divalent cations and/or salts thereof; and (c) mixing the replication deficient viral vectors of step (a) with the solution of step (b). Furthermore, the invention relates to a composition obtained or obtainable by the method of the invention, and to a composition comprising a viral vector and the solution of step (b).Type: ApplicationFiled: August 14, 2020Publication date: October 13, 2022Applicant: Leukocare AGInventors: Eva Reinauer, Kristina Kemter, Jens Altrichter -
Patent number: 11185827Abstract: A surface-modified filter membrane for filtering blood, in particular for separating blood plasma and blood serum, and a method for the production thereof, a filter provided therewith and the use thereof.Type: GrantFiled: July 16, 2018Date of Patent: November 30, 2021Assignee: BOEHRINGER INGELHEIM VETMEDICA GMBHInventors: Christoph Weber, Heinz Schoeder, Jens Altrichter, Roland Kirchner, Stefan Margraf, Michael Scholl
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Patent number: 11060068Abstract: The present invention relates to a method for stabilising viruses or bacteria, the method comprising embedding the viruses or bacteria in an aqueous solution, wherein the solution comprises: (i) at least three different amino acids; or (ii) at least one dipeptide or tripeptide and wherein the solution is free or substantially free of sugar(s), silanes and protein(s).Type: GrantFiled: June 28, 2012Date of Patent: July 13, 2021Assignee: Leukocare AGInventors: Martin Scholz, Jens Altrichter, Kristina Kemter
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Patent number: 10588957Abstract: The present invention relates to a method for producing stabilised vaccines, the method comprising: (a) mixing antigens with a solution comprising: (i) chitosan; (ii) at least three different amino acids and/or at least one dipeptide or tripeptide; and (iii) a sugar; and (b) drying the mixture obtained in (a).Type: GrantFiled: October 24, 2014Date of Patent: March 17, 2020Assignee: LEUKOCARE AGInventors: Martin Scholz, Jens Altrichter, Kristina Kemter, Regina Scherliess, Hartwig Steckel
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Publication number: 20200002673Abstract: A method for preparing a leukocyte preparation from a leukocyte fraction and a correspondingly prepared or obtainable leukocyte preparation and its use. The methods include: a) sedimenting the leukocyte fraction removing leukocyte supernatant from the sediment, wherein the leukocyte supernatant is collected or remains in a leukocyte container, b) sedimenting the leukocytes in the leukocyte container, c) washing the sediment in the leukocyte container with a saline solution, and d) resuspending the sediment in the leukocyte container in a storage solution.Type: ApplicationFiled: July 9, 2019Publication date: January 2, 2020Applicants: ARTCLINE GMBH, FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.Inventors: Jens Altrichter, Steffen Mitzner, Antje Schwarz, Kathleen Selleng, Fanny Doss, Stephanie Koch
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Patent number: 10421776Abstract: The present invention relates to a method for preventing the unfolding of a (poly)peptide during drying and/or inducing the (re-)folding of a (poly)peptide after drying, comprising the step of embedding the (poly)peptide in an aqueous solution, wherein the solution comprises (i) at least three different amino acids; or (ii) at least one dipeptide or tripeptide; and wherein the solution is free or substantially free of (a) sugar; and (b-i) protein; and/or (b-ii) denaturing compounds; and (c) silanes.Type: GrantFiled: January 13, 2016Date of Patent: September 24, 2019Assignee: Leukocare AGInventors: Martin Scholz, Jens Altrichter, Kristina Kemter
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Publication number: 20190256551Abstract: The present invention relates to a method of producing a liquid biopharmaceutical drug product, comprising a biomolecule of interest, the method comprising: (a) a first phase of preparing a drug substance of the biomolecule of interest, said first phase comprising at least one processing step selected from (a1) harvesting, (a2) purification, (a3) re-buffering, and (a4) enrichment, wherein said at least one processing step in this first phase is carried out in the presence of a composition comprising at least three amino acids, wherein the combination of said at least three amino acids provides at least one positively charged functional group, at least one anti-oxidative functional group, at least one osmolytic function, and at least one buffering function, and (b) a second phase of further processing the drug substance prepared in (a) to obtain a liquid biopharmaceutical drug product, said second phase comprising at least one processing step selected from (b1) re-buffering, (b2) freezing, (b3) thawing, and (bType: ApplicationFiled: September 15, 2017Publication date: August 22, 2019Applicant: Leukocare AGInventors: Kristina Kemter, Martin Scholz, Jens Altrichter, Thomas Kriehuber
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Patent number: 10377987Abstract: A method for preparing a leukocyte preparation from a leukocyte fraction and a correspondingly prepared or obtainable leukocyte preparation and its use. The method includes: a) sedimenting the leukocyte fraction removing leukocyte supernatant from the sediment, wherein the leukocyte supernatant is collected or remains in a leukocyte container, b) sedimenting the leukocytes in the leukocyte container, c) washing the sediment in the leukocyte container with a saline solution, and d) resuspending the sediment in the leukocyte container in a storage solution.Type: GrantFiled: December 8, 2014Date of Patent: August 13, 2019Assignees: Artcline GmbH, Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V.Inventors: Jens Altrichter, Steffen Mitzner, Antje Lübcke, Kathleen Selleng, Fanny Doss, Stephanie Koch
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Publication number: 20190216925Abstract: The present invention relates to a method of producing a biopharmaceutical drug product comprising a biomolecule of interest, the method comprising: (a) a first phase of preparing a drug substance of the biomolecule of interest, said first phase comprising at least one processing step selected from (a1) harvesting, (a2) purification, (a3) re-buffering, and (a4) enrichment, wherein said at least one processing step in this first phase is carried out in the presence of a composition comprising at least three amino acids, wherein the combination of said at least three amino acids provides at least one positively charged functional group, at least one anti-oxidative functional group, at least one osmolytic function, and at least one buffering function, and (b) a second phase of further processing the drug substance prepared in (a) to obtain a biopharmaceutical drug product, said second phase comprising at least one processing step selected from (b1) re-buffering, (b2) freezing, (b3) thawing, and (b4) filling; wheType: ApplicationFiled: September 15, 2017Publication date: July 18, 2019Applicant: Leukocare AGInventors: Martin Scholz, Kristina Kemter, Jens Altrichter, Thomas Kriehuber
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Publication number: 20190216734Abstract: The present invention relates to a method of producing low viscous and highly concentrated biopharmaceutical drug products comprising a biomolecule of interest, the method comprising: (a) a first phase of preparing a drug substance of the biomolecule of interest, said first phase comprising at least one processing step selected from (a1) harvesting, (a2) purification, (a3) re-buffering, and (a4) enrichment, wherein said at least one processing step in this first phase is carried out in the presence of a composition comprising at least three amino acids, wherein the combination of said at least three amino acids provides at least one positively charged functional group, at least one anti-oxidative functional group, at least one osmolytic function, and at least one buffering function, and (b) a second phase of further processing the drug substance prepared in (a) to obtain a low viscous and highly concentrated biopharmaceutical drug product, said second phase comprising at least one processing step selected froType: ApplicationFiled: September 15, 2017Publication date: July 18, 2019Applicant: Leukocare AGInventors: Martin Scholz, Kristina Kemter, Jens Altrichter, Thomas Kriehuber
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Publication number: 20190015790Abstract: A surface-modified filter membrane for filtering blood, in particular for separating blood plasma and blood serum, and a method for the production thereof, a filter provided therewith and the use thereof.Type: ApplicationFiled: July 16, 2018Publication date: January 17, 2019Applicant: Boehringer Ingelheim Vetmedica GmbHInventors: Christoph Weber, Heinz Ulrich Gerhard Schoeder, Jens Altrichter, Roland Kirchner, Stefan Margraf, Michael Scholl
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Publication number: 20180339036Abstract: The present invention relates to a method for producing stabilised vaccines, the method comprising: (a) mixing antigens with a solution comprising: (i) chitosan; (ii) at least three different amino acids and/or at least one dipeptide or tripeptide; and (iii) a sugar; and (b) drying the mixture obtained in (a).Type: ApplicationFiled: October 24, 2014Publication date: November 29, 2018Inventors: Martin Scholz, Jens Altrichter, Kristina Kemter, Regina Scherliess, Hartwig Steckel
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Publication number: 20180204137Abstract: The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules immobilized on a solid carrier. The invention furthermore relates to a method for producing stabilized biomolecules, comprising embedding the biomolecules in the compositions according to the invention and a method of producing a solid carrier having biomolecules attached thereto. The invention furthermore relates to a solid carrier producible or produced by the method of the invention and a method of diagnosing a disease using the carrier of the invention.Type: ApplicationFiled: October 18, 2017Publication date: July 19, 2018Inventors: Stefan Margraf, Anja Breuer, Martin Scholz, Jens Altrichter
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Patent number: 9797895Abstract: The present invention relates to the use of a composition comprising (a) at least three different amino acids, (b) at least two different amino acids and a saponin or (c) at least one dipeptide or tripeptide for stabilizing biomolecules immobilized on a solid carrier. The invention furthermore relates to a method for producing stabilized biomolecules, comprising embedding the biomolecules in the composition according to the invention and a method of producing a solid carrier having biomolecules attached thereto. The invention furthermore relates to a solid carrier producible or produced by the method of the invention and a method of diagnosing a disease using the carrier of the invention.Type: GrantFiled: March 31, 2010Date of Patent: October 24, 2017Assignee: Leukocare AGInventors: Stefan Margraf, Anja Breuer, Martin Scholz, Jens Altrichter
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Publication number: 20160215015Abstract: The present invention relates to a method for preventing the unfolding of a (poly)peptide during drying and/or inducing the (re-)folding of a (poly)peptide after drying, comprising the step of embedding the (poly)peptide in an aqueous solution, wherein the solution comprises (i) at least three different amino acids; or (ii) at least one dipeptide or tripeptide; and wherein the solution is free or substantially free of (a) sugar; and (b-i) protein; and/or (b-ii) denaturing compounds; and (c) silanes.Type: ApplicationFiled: January 13, 2016Publication date: July 28, 2016Inventors: Martin Scholz, Jens Altrichter, Kristina Kemter
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Patent number: 9321848Abstract: The present invention relates to a method for preventing the unfolding of a (poly)peptide during drying and/or inducing the (re-)folding of a (poly)peptide after drying, comprising the step of embedding the (poly)peptide in an aqueous solution, wherein the solution comprises (i) at least three different amino acids; or (ii) at least one dipeptide or tripeptide; and wherein the solution is free or substantially free of (a) sugar; and (b-i) protein; and/or (b-ii) denaturing compounds; and (c) silanes.Type: GrantFiled: June 28, 2012Date of Patent: April 26, 2016Assignee: LEUKOCARE AGInventors: Martin Scholz, Jens Altrichter, Kristina Kemter