Patents by Inventor Jens Christoph Thies
Jens Christoph Thies has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11891726Abstract: The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9; m+p+q=1 whereby m or p could be 0; n is about 5 to about 300; (pref.Type: GrantFiled: July 21, 2021Date of Patent: February 6, 2024Assignee: DSM IP ASSETS B.V.Inventors: Mirian Hendrika Jacoba Gillisen-Van Der Vight, Jens Christoph Thies, Gueorgui Mihov
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Method of making an osteoconductive polymer article and an osteoconductive polymer article thus made
Publication number: 20220323651Abstract: The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 ?m; providing a dispersion of bioactive ceramic particles of particle size at most 10 ?m in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent.Type: ApplicationFiled: June 27, 2022Publication date: October 13, 2022Inventors: Jens Christoph THIES, Ruud Jozef Regina Wilhelmus PETERS, Pieter J. EMANS, Jacob KOENEN -
Method of making an osteoconductive polymer article and an osteoconductive polymer article thus made
Patent number: 11400184Abstract: The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 ?m; providing a dispersion of bioactive ceramic particles of particle size at most 10 ?m in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent. Further disclosed is an osteoconductive polymer article for use as an orthopedic implant, which article is made from a biocompatible, non-biodegradable polymer and comprises a non-flat surface with roughness Ra of at least 5 ?m, wherein bioactive ceramic particles of particle size at most 10 ?m are partly embedded in the polymer at the surface of the article.Type: GrantFiled: October 5, 2018Date of Patent: August 2, 2022Assignee: DSM IP ASSETS B.V.Inventors: Jens Christoph Thies, Ruud Jozef Regina Wilhelmus Peters, Pieter J. Emans, Jacob Koenen -
Publication number: 20220002912Abstract: The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9; m+p+q=1 whereby m or p could be 0; n is about 5 to about 300; (pref.Type: ApplicationFiled: July 21, 2021Publication date: January 6, 2022Inventors: Mirian Hendrika Jacoba GILLISEN-VAN DER VIGHT, Jens Christoph THIES, Gueorgui MIHOV
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Method of making an osteoconductive polymer article and an osteoconductive polymer article thus made
Publication number: 20200316259Abstract: The disclosure relates to methods of making an osteoconductive polymer article for use as an orthopedic implant comprises steps of forming an article from a biocompatible, non-biodegradable polymer, the article comprising a non-flat surface with roughness Ra of at least 5 ?m; providing a dispersion of bioactive ceramic particles of particle size at most 10 ?m in a first solvent comprising a solvent for the polymer; coating at least the non-flat surface with the dispersion in at least one step; and rinsing the coated article with a second solvent being a non-solvent for the polymer to substantially remove the first solvent. Further disclosed is an osteoconductive polymer article for use as an orthopedic implant, which article is made from a biocompatible, non-biodegradable polymer and comprises a non-flat surface with roughness Ra of at least 5 ?m, wherein bioactive ceramic particles of particle size at most 10 ?m are partly embedded in the polymer at the surface of the article.Type: ApplicationFiled: October 5, 2018Publication date: October 8, 2020Inventors: Jens Christoph THIES, Ruud Jozef Regina Wilhelmus PETERS, Pieter J. EMANS, Jacob KOENEN -
Publication number: 20200230069Abstract: Compositions suitable for forming an optical coating are provided, wherein the compositions include core-shell nanoparticles having (a) a core material which includes a polymer; and (b) a shell material which includes a metal oxide.Type: ApplicationFiled: April 8, 2020Publication date: July 23, 2020Inventors: Nanning Joerg ARFSTEN, Steven ARMES, Pascal Jozef Paul BUSKENS, Jens Christoph THIES, Patrick Wilhelmus Antonius VRIJALDENHOVEN
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Publication number: 20200087819Abstract: The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (iv), wherein ?m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9, ?m+p+q=1 whereby m or p could be 0, ?n is about 5 to about 300; (pref.Type: ApplicationFiled: November 20, 2019Publication date: March 19, 2020Inventors: Mirian Hendrika Jacoba GILLISSEN-VAN DER VIGHT, Jens Christoph THIES, Gueorgui MIHOV
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Patent number: 10538864Abstract: The present inventioN relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV), wherein ?m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9, ?m+p+q=1 whereby m or p could be 0, ?n is about 5 to about 300; (pref. 50-200), —R1 is independently selected from the group consisting of (C2-C20) alkylene or (C2-C20) alkenylene and combinations thereof; —R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, —(CH2)SH, —(CH2)2S(CH3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(?NH2+)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2CH2COOH, CH3—CH2—CH(CH3)—, (CH3)2—CH—CH2—, H2N—(CH2)4—, Ph-CH2—, CH?C—CH2—, HO-p-Ph-CH2—, (CH3)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH?N—CH?C—CH2—.Type: GrantFiled: October 24, 2013Date of Patent: January 21, 2020Assignee: DSM IP ASSETS, B.V.Inventors: Mirian Hendrika Jacoba Gillissen-Van Der Vight, Jens Christoph Thies, George Mihov
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Patent number: 10123972Abstract: The present disclosure relates to fibers implantable in the body of a human or animal and processes for manufacturing such a fiber. The fiber undergoes a reduction in surface area to volume ratio of a factor of 1.05-10 upon injection in the human or animal body. In an embodiment, a process for manufacturing a fiber comprises extruding a biodegradable polymer into a fiber capable of fitting in a syringe needle of at least 25 Gauge, and cooling the fiber below its dry glass transition temperature while the fiber is under tension.Type: GrantFiled: April 11, 2017Date of Patent: November 13, 2018Assignee: DSM IP ASSETS, B.V.Inventors: Astrid Franken, George Mihov, Jens Christoph Thies
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Publication number: 20180078509Abstract: Compositions suitable for forming an optical coating are provided, wherein the compositions include core-shell nanoparticles having (a) a core material which includes a polymer; and (b) a shell material which includes a metal oxide.Type: ApplicationFiled: November 29, 2017Publication date: March 22, 2018Inventors: Nanning Joerg ARFSTEN, Steven ARMES, Pascal Jozef Paul BUSKENS, Jens Christoph THIES, Patrick Wilhelmus Antonius VRIJALDENHOVEN
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Patent number: 9855219Abstract: The present invention relates to a composition suitable for forming an optical coating, the composition comprising core-shell nanoparticles, wherein said nanoparticles comprise: (a) core material comprising polymer; and (b) shell material comprising metal oxide.Type: GrantFiled: September 5, 2007Date of Patent: January 2, 2018Assignee: DSM IP ASSETS B.V.Inventors: Nanning Joerg Arfsten, Steven Armes, Pascal Jozef Paul Buskens, Jens Christoph Thies, Patrick Wilhelmus Antonius Vrijaldenhoven
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Patent number: 9789189Abstract: Drug delivery compositions are provided having proteins and biodegradable polymers that may be used for controlled and long term release of proteins into a biological environment. According to some embodiments, the drug delivery composition may be provided with at least a protein and a biodegradable polymer possessing at least two different functional groups selected from the group of chosen among carboxyl, ester, amine, amide, thiol, thioester or hydroxyl groups pendant to the main polymer chain whereby the composition absorbs between 5-10% w/w water when exposed to physiological conditions for at least 20 days. A drug delivery system for controlled protein release which includes the drug delivery composition is also provided whereby the drug delivery system may be in the form of microparticles, films, coatings, fibers, pellets, cylinders, discs, implants, microcapsules, microspheres, nanospheres, wafers, micelles, liposomes or woven or non-woven fabrics.Type: GrantFiled: October 2, 2013Date of Patent: October 17, 2017Assignee: DSM IP ASSETS BVInventors: Jens Christoph Thies, George Mihov, Guy Draaisma
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Publication number: 20170216201Abstract: The present disclosure relates to fibers implantable in the body of a human or animal and processes for manufacturing such a fiber. The fiber undergoes a reduction in surface area to volume ratio of a factor of 1.05-10 upon injection in the human or animal body. In an embodiment, a process for manufacturing a fiber comprises extruding a biodegradable polymer into a fiber capable of fitting in a syringe needle of at least 25 Gauge, and cooling the fiber below its dry glass transition temperature while the fiber is under tension.Type: ApplicationFiled: April 11, 2017Publication date: August 3, 2017Inventors: Astrid Franken, George Mihov, Jens Christoph Thies
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Publication number: 20170119813Abstract: The present invention relates to a formulation sized for injection comprising a biodegradable polyesteramide co-polymer comprising at least a diol of bicyclic-1,4:3,6-dianhydrohexitol and analgesics for use in the treatment of arthritic disorders. More specific the invention relates to a formulation comprising injectable microparticle according to claim 1 wherein the polyesteramide co-polymer further comprises a diacid, a diol different from bicyclic-1,4:3,6-dianhydrohexitol and at least two different amino-acids. The formulation is used to treat pain or inflammation in a patient comprising administering to said patient a therapeutically effective amount of the formulation once or twice a year.Type: ApplicationFiled: March 6, 2015Publication date: May 4, 2017Inventors: Jens Christoph THIES, Detlef Olaf Alexander SCHUMANN, George MIHOV, Julien François BERARD
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Patent number: 9545161Abstract: The invention relates to an article comprising a substrate and a nano-porous coating, wherein the reflectivity of the article is less then 2%, and whereby the amount of sodium measured in the coating by XPS is less then 1 wt %, and further to a method of making the article.Type: GrantFiled: February 12, 2007Date of Patent: January 17, 2017Assignee: DSM IP ASSETS B.V.Inventors: Jens Christoph Thies, Patrick Wilhelmus Antonius Vrijaldenhoven, Hermanus Adrianus Langermans
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Publication number: 20160102176Abstract: The present invention relates to a fiber comprising a biodegradable polymer which undergoes dimensional change upon injection in the human or animal body wherein the dimensional change is a reduction of the surface area to volume ratio of a factor 2 to 10. The fiber is sized for injection via a pharmaceutical syringe needle having a bore of at least 25 Gauge. The biodegradable polymer is an amorphous biodegradable polymer selected from the group of poly-hex am ethylene carbonates or polyesteramides. The amorphous biodegradable polymer is a preferably a polyesteramide comprising alpha-amino acids, diols and dicarboxylic acids as building blocks. The invention further relates to the use of the fiber for the manufacturing of a medicament for the treatment of ophthalmic diseases. The invention also relates to a process for the manufacturing of the fiber comprising the following process steps; a. extruding a biodegradable polymer into a fiber fitting in a needle of at least 25 Gauge b.Type: ApplicationFiled: December 18, 2015Publication date: April 14, 2016Inventors: Astrid FRANKEN, George MIHOV, Jens Christoph THIES
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Publication number: 20150240387Abstract: The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9, m+p+q=1 whereby m or p could be 0, n is about 5 to about 300; (pref. 50-200), —R1 is independently selected from the group consisting of (C2-C20) alkylene or (C2-C20) alkenylene and combinations thereof; —R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, —(CH2)SH, —(CH2)2S(CH3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(?NH2+)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —NH—CH2CH2COOH, CH3—CH2—CH(CH3)—, (CH3)2—CH—CH2—, H2N—(CH2)4—, Ph-CH2—, CH?C—CH2—, HO-p-Ph-CH2—, (CH3)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH?N—CH?C—CH2—.Type: ApplicationFiled: October 24, 2012Publication date: August 27, 2015Inventors: Mirian Hendrika Jacoba Gillissen-Van Der Vight, Jens Christoph Thies, George Mihov
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Publication number: 20150216987Abstract: The present invention relates to a drug delivery composition comprising proteins and biodegradable polymers. The present invention further relates to a drug delivery system for controlled and long term release of proteins into a biological environment. The drug delivery composition comprises at least a protein and a biodegradable polymer possessing at least two different functional groups selected from the group of chosen among carboxyl-, ester-, amine-, amide-, thiol-, thioester- or hydroxyl groups pendant to the main polymer chain whereby the composition absorbs between 5-10% w/w water when exposed to physiological conditions for at least 20 days. The present invention further relates to a drug delivery system for controlled protein release comprising the composition. The drug delivery system may be chosen from microparticles, films, coatings, fibers, pellets, cylinders, discs, implants, microcapsules, microspheres, nanospheres, wafers, micelles, liposomes or woven or non-woven fabrics.Type: ApplicationFiled: October 2, 2013Publication date: August 6, 2015Inventors: Jens Christoph Thies, George Mihov, Guy Draaisma
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Publication number: 20140179802Abstract: The present invention relates to a fiber comprising a biodegradable polymer which undergoes dimensional change upon injection in the human or animal body wherein the dimensional change is a reduction of the surface area to volume ratio of a factor 2 to 10. The fiber is sized for injection via a pharmaceutical syringe needle having a bore of at least 25 Gauge. The biodegradable polymer is an amorphous biodegradable polymer selected from the group of poly-hexamethylene carbonates or polyesteramides. The amorphous biodegradable polymer is a preferably a polyesteramide comprising alpha-amino acids, diols and dicarboxylic acids as building blocks. The invention further relates to the use of the fiber for the manufacturing of a medicament for the treatment of ophthalmic diseases. The invention also relates to a process for the manufacturing of the fiber comprising the following process steps; a. extruding a biodegradable polymer into a fiber fitting in a needle of at least 25 Gauge b.Type: ApplicationFiled: May 2, 2012Publication date: June 26, 2014Applicant: DSM IP ASSETS B.V.Inventors: Astrid Franken, George Mihov, Jens Christoph Thies
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Publication number: 20140105957Abstract: The present invention relates to an ocular polymer delivery composition comprising at least one ophthalmologic agent dispersed in at least one biodegradable polymer, wherein the polymer comprises at least one of a poly (ester amide) (PEA) having a chemical formula described by structural formula (I).Type: ApplicationFiled: May 2, 2012Publication date: April 17, 2014Applicant: DSM IP ASSETS B.V.Inventors: Astrid Franken, George Mihov, Jens Christoph Thies