Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Abstract: The present invention features interferon-free therapies for the treatment of HCV. Preferably, the treatment is over a shorter duration of treatment, such as no more than 12 weeks. In one aspect, the treatment comprises administering at least two direct acting antiviral agents to a subject with HCV infection, wherein the treatment lasts for 12 weeks and does not include administration of either interferon or ribavirin, and said at least two direct acting antiviral agents comprise (a) Compound 1 or a pharmaceutically acceptable salt thereof and (b) Compound 2 or a pharmaceutically acceptable salt thereof.

Abstract: The leading end of a running fresh web of cigarette paper or the like is spliced to the trailing end of a running expiring web while the ends travel at the same speed, in the same direction and next to each other. The splicing unit includes a rotatable roll at one side of the path for the advancing ends, and a rotary carrier at the other side of such path opposite the roll. The carrier is provided with a segment having a convex knurling surface which cooperates with the peripheral surface of the roll to provide the webs with a splice while the segment engages the adjacent web. Prior to splicing, the carrier is rotated in a first direction to move the segment away from the path for the webs, and such movement is followed by rotation of the carrier in a second direction to accelerate the knurling surface at least close (a) to the common speed of the webs and (b) at least close to the speed of the peripheral surface of the roll.

Abstract: The leading end of a running fresh web of cigarette paper or the like is spliced to the trailing end of a running expiring web while the ends travel at the same speed, in the same direction and next to each other. The splicing unit includes a rotatable roll at one side of the path for the advancing ends, and a rotary carrier at the other side of such path opposite the roll. The carrier is provided with a segment having a convex knurling surface which cooperates with the peripheral surface of the roll to provide the webs with a splice while the segment engages the adjacent web. Prior to splicing, the carrier is rotated in a first direction to move the segment away from the path for the webs, and such movement is followed by rotation of the carrier in a second direction to accelerate the knurling surface at least close (a) to the common speed of the webs and (b) at least close to the speed of the peripheral surface of the roll.

Abstract: The application of (for example, elongated strip-shaped) spots of adhesive paste to successive objects (such as paper or cardboard blanks which are to be converted into soft or hinged-lid packs for arrays of cigarettes) which are advanced stepwise below the nozzle or nozzles of one or more pasters at an adhesive-applying station is regulated by a control unit which receives signals denoting the speed of the conveyor for the objects and the position of the object at the adhesive-applying station. The control unit regulates the operation of the valve for each nozzle of the paster by taking into consideration the inertia of electrical and mechanical constituents of the paster. This ensures the application of spots having an optimum shape and an optimum position relative to the respective objects and containing predetermined quantities of adhesive.

Abstract: The application of (for example, elongated strip-shaped) spots of adhesive paste to successive objects (such as paper or cardboard blanks which are to be converted into soft or hinged-lid packs for arrays of cigarettes) which are advanced stepwise below the nozzle or nozzles of one or more pasters at an adhesive-applying station is regulated by a control unit which receives signals denoting the speed of the conveyor for the objects and the position of the object at the adhesive-applying station. The control unit regulates the operation of the valve for each nozzle of the paster by taking into consideration the inertia of electrical and mechanical constituents of the paster. This ensures the application of spots having an optimum shape and an optimum position relative to the respective objects and containing predetermined quantities of adhesive.

Abstract: The application of (for example, elongated strip-shaped) spots of adhesive paste to successive objects (such as paper or cardboard blanks which are to be converted into soft or hinged-lid packs for arrays of cigarettes) which are advanced stepwise below the nozzle or nozzles of one or more pasters at an adhesive-applying station is regulated by a control unit which receives signals denoting the speed of the conveyor for the objects and the position of the object at the adhesive-applying station. The control unit regulates the operation of the valve for each nozzle of the paster by taking into consideration the inertia of electrical and mechanical constituents of the paster. This ensures the application of spots having an optimum shape and an optimum position relative to the respective objects and containing predetermined quantities of adhesive.

Abstract: A wheel-shaped conveyor with radially extending pockets for discrete packets of cigarettes is indexible about a horizontal axis between the neighboring surfaces of two upright walls forming part of a support for the conveyor and flanking a selected portion of an arcuate path for successive packets in the respective pockets of the conveyor. The upright walls have orifices which direct streamlets of compressed air against the adjacent sidewalls of the packets advancing along the selected portion of the path so that the streamlets of air can promote setting of the freshly applied adhesive between the panels of those sidewalls of the packets which advance along the respective upright walls of the support. The streamlets of air establish cushions of air between the moving sidewalls of the packets and the stationary walls of the support to thus reduce the likelihood of defacing and/or otherwise damaging the sidewalls.

Abstract: The pot of a paster, such as a paster which can apply a flowable adhesive to a series of coherent blanks or to successive discrete blanks in a cigarette packing machine, receives a suitable adhesive from the discharge end of a suction nozzle. The latter has an intake end which can be introduced into supplies of adhesive in successive vessels of a series of two or more vessels. The suction nozzle carries a container which is at least partially filled with adhesive while the intake end of the nozzle draws adhesive from a vessel, and the thus at least partially filled container supplies adhesive to the intake end of the nozzle during transfer of the nozzle from an emptied vessel into a filled vessel. This ensures that the nozzle can supply adhesive to the paster while its intake end dips into the supply of adhesive in a vessel as well as while the intake end is being advanced from an emptied vessel into an at least partially filled vessel.

Abstract: Successive block-shaped arrays of cigarettes are advanced by one or more pushers on an endless conveyor through an elongated channel, defined by a stationary guide, on their way into a receptacle of a wrapping unit for the arrays. The pusher or pushers are decelerated during advancement through the discharge end of the channel, and the arrays are braked during such deceleration to maintain them in uninterrupted contact with the pusher or with the respective pushers until the arrays complete their movement into a predetermined portion of the receptacle. For example, the arrays can be braked by one or more mechanical devices and/or by one or more pneumatic devices.