Patents by Inventor Jens Ducree

Jens Ducree has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10537890
    Abstract: Microfluidic devices that are configured to use centrifugal forces to bias particles into one or more capture regions based on their individual sizes are described.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: January 21, 2020
    Assignee: Dublin City University
    Inventors: Jens Ducree, Macdara Glynn, Charles Nwankire
  • Publication number: 20190321820
    Abstract: The present invention relates to fluidic devices, especially microfluidic devices, for aliquoting and pairwise combinatorial mixing of a first set of liquids with a second set of liquids. The device architecture is designed to move liquids in two separate phases, a first phase where the liquids are exposed to a first directional force field to move the liquids in a first direction, from a reservoir to aliquot chambers, and a second phase where the liquids are exposed to a second directional force field to move the liquids in a second direction, from the aliquot chambers to the mixing chambers. The first and second directional force fields that the device is exposed to may be achieved using a single directional force field (i.e. a rotor driven centrifugal force field) and by re-orienting the position of the device with respect to the centrifugal forces between the first and second phases of operation.
    Type: Application
    Filed: November 28, 2017
    Publication date: October 24, 2019
    Applicant: DUBLIN CITY UNIVERSITY
    Inventors: David KINAHAN, Jens DUCREE
  • Patent number: 10173216
    Abstract: A particle capture system that can be used in the context of a lab-on-a-chip platform for particle- and cell-based assays is described. The system comprises a capture chamber comprising a plurality of capture sites, the capture sites defining a capture area configured to receive individual particles travelling within the capture chamber. By rotating the chamber, the individual particles are biased towards the capture sites where they may be captured.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: January 8, 2019
    Assignee: DUBLIN CITY UNIVERSITY
    Inventors: Jens Ducree, Robert Burger
  • Publication number: 20170368550
    Abstract: Microfluidic devices that are configured to use centrifugal forces to bias particles into one or more capture regions based on their individual sizes are described.
    Type: Application
    Filed: January 12, 2016
    Publication date: December 28, 2017
    Inventors: Jens Ducree, Macdara Glynn, Charles Nwankire
  • Publication number: 20160121329
    Abstract: Microfluidic devices and in particular microfluidic devices incorporating a cascading valve arrangement for selectively controlling the flow of a fluid within the microfluidic device are described. Specific examples of a microfluidic device comprising a sacrificial valve (210) whose opening is triggered by the opening of a second valve (220), causing a retraction of a fluid spacer (213) thus bringing liquid (214) into contact with the dissolvable valve membrane (210).
    Type: Application
    Filed: June 13, 2014
    Publication date: May 5, 2016
    Inventors: David Kinahan, Jens Ducree, Nikolay Dimov, Sinead Kearney, Elizaveta Vereshchagina, Jennifer Gaughran, Robert Burger, Louise Barrett
  • Patent number: 9295990
    Abstract: Microfluidic devices and in particular microfluidic devices incorporating a valve for selectively controlling the flow of a fluid within the microfluidic device are described. Specific examples of a microfluidic device are described, comprising a sacrificial valve, desirably one that is dissolvable on contact with a fluid or that is configured to disintegrate or dissolve on experiencing a predetermined pressure.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: March 29, 2016
    Assignee: DUBLIN CITY UNIVERSITY
    Inventors: Jens Ducrée, Robert Gorkin, Charles Nwankire
  • Publication number: 20150018192
    Abstract: A particle capture system that can be used in the context of a lab-on-a-chip platform for particle- and cell-based assays is described. The system comprises a capture chamber comprising a plurality of capture sites, the capture sites defining a capture area configured to receive individual particles travelling within the capture chamber. By rotating the chamber, the individual particles are biased towards the capture sites where they may be captured.
    Type: Application
    Filed: July 18, 2014
    Publication date: January 15, 2015
    Inventors: Jens Ducree, Robert Burger
  • Patent number: 8906669
    Abstract: A sequential flow analysis tool comprising a microfluidic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.
    Type: Grant
    Filed: October 9, 2009
    Date of Patent: December 9, 2014
    Assignee: Dublin City University
    Inventors: Ivan Dimov, Jens Ducree, Luke Lee, Gregor Kijanka
  • Publication number: 20140224349
    Abstract: Microfluidic devices and in particular microfluidic devices incorporating a valve for selectively controlling the flow of a fluid within the microfluidic device are described. Specific examples of a microfluidic device are described, comprising a sacrificial valve, desirably one that is dissolvable on contact with a fluid or that is configured to disintegrate or dissolve on experiencing a predetermined pressure.
    Type: Application
    Filed: June 1, 2012
    Publication date: August 14, 2014
    Applicant: Dublin City University
    Inventors: Jens Ducrée, Robert Gorkin, Charles Nwankire
  • Patent number: 8482734
    Abstract: A device consisting of a rotatable substrate (10) with at least one cavity (14) or channel/chamber structures is described. Fluids may be provided into the at least one cavity (14) and on rotation of the substrate will experience the effects of pseudo forces. At least one functional element (15, 16) which is based on organic conductors as for instance an LED or a photodiode is connected with the rotatable substrate.
    Type: Grant
    Filed: June 30, 2008
    Date of Patent: July 9, 2013
    Assignee: Dublin City University
    Inventor: Jens Ducrée
  • Publication number: 20120219727
    Abstract: The formation of a barrier layer within individual channels or cavities of a microfluidic device is described. The barrier layer is effected through a gas phase deposition process, desirably implemented in a plasma environment using a gas plasma reactor. Judicious selection of a precursor compound used within the gas plasma reactor can provide for generation of a layer on the individual surfaces. Desirably the surface or barrier layer is generated through the chemical adsorption of a metalloid oxide such as a silicon oxide layer on the surface of the individual channels or cavities.
    Type: Application
    Filed: June 18, 2010
    Publication date: August 30, 2012
    Applicant: Dublin City University
    Inventors: Ram Prasad Gandhiraman, Lourdes Basabe-Desmonts, Asif Riaz, Luke Lee, Ivan Dimov, Jens Ducree, Stephen Michael Daniels
  • Publication number: 20120040843
    Abstract: A particle capture system that can be used in the context of a lab-on-a-chip platform for particle- and cell-based assays is described. The system comprises a capture chamber comprising a plurality of capture sites, the capture sites defining a capture area configured to receive individual particles travelling within the capture chamber. By rotating the chamber, the individual particles are biased towards the capture sites where they may be captured.
    Type: Application
    Filed: August 12, 2010
    Publication date: February 16, 2012
    Applicant: DUBLIN CITY UNIVERSITY
    Inventors: Jens Ducree, Robert Burger
  • Patent number: 8096314
    Abstract: A fluidic device includes a fluidic module with a first fluid chamber and a second fluid chamber closed with the exception of a fluidic connection to the first fluid chamber. A drive is formed to impart the fluidic module with a first rotation at a rotational frequency below a rotational frequency threshold at which liquid is pneumatically held in the first fluid chamber and does not enter the second fluid chamber. The drive is further formed to impart the fluidic module with a second rotation at a second rotational frequency above the rotational frequency threshold at which a liquid column created in the first fluid chamber becomes unstable and the liquid enters the second fluid chamber.
    Type: Grant
    Filed: January 8, 2009
    Date of Patent: January 17, 2012
    Assignee: Hahn-Schickard-Gesellschaft fuer angewandte Forschung e.V.
    Inventors: Daniel Mark, Stefan Haeberle, Felix Von Stetten, Jens Ducree
  • Publication number: 20110262906
    Abstract: A sequential flow analysis tool comprising a microti iridic device having a fluid path defined within a substrate between an input and an output is described. The device includes a capture chamber provided within but offset from the fluid path, the capture chamber extending into the substrate in a direction substantially perpendicular to the fluid path such that operably particles provided within a fluid flowing within the fluid path will preferentially collect within the capture chamber.
    Type: Application
    Filed: October 9, 2009
    Publication date: October 27, 2011
    Applicant: DUBLIN CITY UNIVERSITY
    Inventors: Ivan Dimov, Jens Ducree, Luke Lee, Gregor Kijanka
  • Patent number: 7943386
    Abstract: An apparatus for determining the volume fractions of the phases in a suspension includes a body, a channel structure, which is formed in the body, and an inlet area and a blind channel, which is fluidically connected to and capable of being filled via the same. Furthermore, a drive for imparting the body with rotation, so that phase separation of the suspension in the blind channel takes place, is provided. The blind channel includes such a channel cross-section and/or such wetting properties that, when filling same via the inlet area, higher capillary forces act in a first cross-sectional area than in a second cross-sectional area, so that at first the first cross-sectional area fills in the direction from the inlet area toward the blind end of the blind channel and then the second cross-sectional area fills in the direction from the blind end toward the inlet area.
    Type: Grant
    Filed: October 5, 2006
    Date of Patent: May 17, 2011
    Assignee: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Markus Grumann, Jens Ducrée, Roland Zengerle, Lutz Riegger
  • Publication number: 20100307595
    Abstract: A fluidic device includes a fluidic module with a first fluid chamber and a second fluid chamber closed with the exception of a fluidic connection to the first fluid chamber. A drive is formed to impart the fluidic module with a first rotation at a rotational frequency below a rotational frequency threshold at which liquid is pneumatically held in the first fluid chamber and does not enter the second fluid chamber. The drive is further formed to impart the fluidic module with a second rotation at a second rotational frequency above the rotational frequency threshold at which a liquid column created in the first fluid chamber becomes unstable and the liquid enters the second fluid chamber.
    Type: Application
    Filed: January 8, 2009
    Publication date: December 9, 2010
    Applicant: Hahn-Schickard-Gesellschaft fuer angewandte Forschung e.V.
    Inventors: Daniel MARK, Stefan HAEBERLE, Felix VON STETTEN, Jens DUCREE
  • Publication number: 20100245815
    Abstract: A device consisting of a rotatable substrate (10) with at least one cavity (14) or channel/chamber structures is described. Fluids may be provided into the at least one cavity (14) and on rotation of the substrate will experience the effects of pseudo forces. At least one functional element (15, 16) which is based on organic conductors as for instance an LED or a photodiode is connected with the rotatable substrate.
    Type: Application
    Filed: June 30, 2008
    Publication date: September 30, 2010
    Inventor: Jens Ducree
  • Patent number: 7748962
    Abstract: A fluid handling apparatus includes a body, which comprises a fluid handling structure, and a flexible membrane attached to the body and formed to interact with a fluid in the fluid handling structure, wherein the membrane comprises a first actuation component. A second actuation component is provided, wherein the first and the second actuation component are formed such that the same attract or repel each other in a first positional relationship, in order to actuate the flexible membrane. A driving means is provided to move the body relative to the second actuation component, in order to bring the first and the second actuation component into the first and out of the first positional relationship.
    Type: Grant
    Filed: January 18, 2007
    Date of Patent: July 6, 2010
    Assignee: Albert-Ludwigs-Universitaet Freiburg
    Inventors: Stefan Haeberle, Jens Ducrée, Roland Zengerle, Norbert Schmitt
  • Publication number: 20090197977
    Abstract: A device for producing a mixture of two phases that are insoluble in each other comprises a first fluid channel and a second fluid channel which lead into a contact region. Also, a third fluid channel is provided which leads into the contact region. The device comprises an imparter configured to impart a rotation on the fluid channels, a first phase being centrifugally supplied to the contact region through the first fluid channel, and a second phase, insoluble in the first phase, being supplied to the contact region through the second fluid channel, compressive and/or shearing forces in the contact region which are centrifugally/hydrodynamically induced by the rotation causing drops to break away in one of the phases supplied in order to produce the mixture of the first and second phases.
    Type: Application
    Filed: September 19, 2006
    Publication date: August 6, 2009
    Inventors: Stefan Haeberle, Jens Ducree, Roland Zengerle
  • Publication number: 20080280365
    Abstract: An apparatus for determining the volume fractions of the phases in a suspension includes a body, a channel structure, which is formed in the body, and an inlet area and a blind channel, which is fluidically connected to and capable of being filled via the same. Furthermore, a drive for imparting the body with rotation, so that phase separation of the suspension in the blind channel takes place, is provided. The blind channel includes such a channel cross-section and/or such wetting properties that, when filling same via the inlet area, higher capillary forces act in a first cross-sectional area than in a second cross-sectional area, so that at first the first cross-sectional area fills in the direction from the inlet area toward the blind end of the blind channel and then the second cross-sectional area fills in the direction from the blind end toward the inlet area.
    Type: Application
    Filed: October 5, 2006
    Publication date: November 13, 2008
    Applicant: ALBERT-LUDWIGS-UNIVERSIITAT FREIBURG
    Inventors: Markus Grumann, Jens Ducree, Roland Zengerle, Lutz Riegger