Abstract: The present invention features methods for self-learning, self-engineering microarrays for the analysis of complex mixtures of nucleic acids and systems and apparatuses embodying such methods. In more particular aspects, the present invention features methods and systems that include inputting data relating to one or more biomolecules into a database; identifying at least one of a plurality of groupings for data to be obtained (mined) from the universal database; inputting at least one of the groupings into a neural network program, which can analyze the data and generate new design rules for predicting biological data; and adapting a software program including initial design rules to the new design rules.