Patents by Inventor Jens Harborth
Jens Harborth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11926831Abstract: This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2?-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases.Type: GrantFiled: May 3, 2022Date of Patent: March 12, 2024Assignee: Nitto Denko CorporationInventors: Kenjirou Minomi, Jens Harborth, Cima Cina, Wenbin Ying, Jane Zheng, Narendra Vaish
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Publication number: 20220267779Abstract: This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2?-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases.Type: ApplicationFiled: May 3, 2022Publication date: August 25, 2022Inventors: Kenjirou Minomi, Jens Harborth, Cima Cina, Wenbin Ying, Jane Zheng, Narendra Vaish
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Patent number: 11390871Abstract: This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2?-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases.Type: GrantFiled: June 25, 2019Date of Patent: July 19, 2022Assignee: Nitto Denko CorporationInventors: Kenjirou Minomi, Jens Harborth, Cima Cina, Wenbin Ying, Jane Zheng, Narendra Vaish
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Patent number: 11359202Abstract: This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2?-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases.Type: GrantFiled: June 25, 2019Date of Patent: June 14, 2022Assignee: Nitto Denko CorporationInventors: Kenjirou Minomi, Jens Harborth, Cima Cina, Wenbin Ying, Jane Zheng, Narendra Vaish
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Publication number: 20220049251Abstract: Disclosed are compositions that include double-stranded ribonucleic acid (dsRNA) constructs that inhibit expression or translation of a Coronavirus protein, and methods of using them to treat MERS, SARS, Covid-19 and/or symptoms thereof. Some embodiments relate to a method for preventing, treating, inhibiting, or ameliorating a MERS, SARS, or Covid-19 symptom using a composition herein disclosed. In some embodiments the composition targets the lung.Type: ApplicationFiled: May 19, 2021Publication date: February 17, 2022Inventors: Jens Harborth, Cima Cina, Bharat Majeti, Roger Adami, Wenbin Ying
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Publication number: 20220047619Abstract: Compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.Type: ApplicationFiled: June 25, 2021Publication date: February 17, 2022Inventors: Kenjirou MINOMI, Hirokazu TAKAHASHI, Erika TERADA, Jens HARBORTH, Jun ZHANG, Mohammad AHMADIAN, Wenbin YING
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Patent number: 11045488Abstract: This invention provides compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.Type: GrantFiled: August 12, 2018Date of Patent: June 29, 2021Assignee: Nitto Denko CorporationInventors: Kenjirou Minomi, Hirokazu Takahashi, Erika Terada, Jens Harborth, Jun Zhang, Mohammad Ahmadian, Wenbin Ying
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Publication number: 20190323015Abstract: This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2?-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases.Type: ApplicationFiled: June 25, 2019Publication date: October 24, 2019Inventors: Kenjirou Minomi, Jens Harborth, Cima Cina, Wenbin Ying, Jane Zheng, Narendra Vaish
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Patent number: 10405749Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding p21; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.Type: GrantFiled: December 28, 2015Date of Patent: September 10, 2019Assignee: Nitto Denko CorporationInventors: Kenjirou Minomi, Jens Harborth, Cima Cina, Kwok Yin Tsang, Wenbin Ying, Hirokazu Takahashi
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Patent number: 10358647Abstract: This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2?-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases.Type: GrantFiled: December 12, 2016Date of Patent: July 23, 2019Assignee: NITTO DENKO CORPORATIONInventors: Kenjirou Minomi, Jens Harborth, Cima Cina, Wenbin Ying, Jane Zheng, Narendra Vaish
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Publication number: 20180369274Abstract: This invention provides compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.Type: ApplicationFiled: August 12, 2018Publication date: December 27, 2018Inventors: Kenjirou Minomi, Hirokazu Takahashi, Erika Terada, Jens Harborth, Jun Zhang, Mohammad Ahmadian, Wenbin Ying
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Publication number: 20180235995Abstract: This invention provides methods and compositions for inhibiting Ebola virus and Ebola infection utilizing gene silencing siRNAs. The siRNAs can be targeted to one or more Ebola genes including NP, VP30, VP35, L polymerase, glycoprotein (GP), VP24, VP40, and intergenic overlapping regions selected from NP/VP35, VP35/VP40, GP/VP30, and VP24/L. A composition containing the siRNAs can be administered in a delivery vehicle such as liposomes.Type: ApplicationFiled: February 18, 2016Publication date: August 23, 2018Inventors: Wenbin Ying, Bharat Majeti, Jens Harborth, Roger Adami
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Patent number: 10047111Abstract: This invention provides compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.Type: GrantFiled: December 28, 2015Date of Patent: August 14, 2018Assignee: Nitto Denko CorporationInventors: Kenjirou Minomi, Hirokazu Takahashi, Erika Terada, Jens Harborth, Jun Zhang, Mohammad Ahmadian, Wenbin Ying
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Patent number: 10047110Abstract: This invention provides compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. A nucleic acid molecule can have a) a polynucleotide sense strand and a polynucleotide antisense strand; b) each strand of the molecule being from 15 to 30 nucleotides in length; c) a contiguous region of from 15 to 30 nucleotides of the antisense strand being complementary to a sequence of an mRNA encoding GST-?; and d) at least a portion of the sense strand can be complementary to at least a portion of the antisense strand, and the molecule has a duplex region of from 15 to 30 nucleotides in length.Type: GrantFiled: December 28, 2015Date of Patent: August 14, 2018Assignee: Nitto Denko CorporationInventors: Kenjirou Minomi, Hirokazu Takahashi, Erika Terada, Jens Harborth, Jun Zhang, Mohammad Ahmadian, Wenbin Ying
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Patent number: 10023597Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.Type: GrantFiled: June 27, 2017Date of Patent: July 17, 2018Assignee: Nitto Denko CorporationInventors: Kenjirou Minomi, Jens Harborth, Cima Cina, Kwok Yin Tsang, Wenbin Ying, Hirokazu Takahashi
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Publication number: 20170298086Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.Type: ApplicationFiled: June 27, 2017Publication date: October 19, 2017Inventors: Kenjirou Minomi, Jens Harborth, Cima Cina, Kwok Yin Tsang, Wenbin Ying, Hirokazu Takahashi
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Patent number: 9695206Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.Type: GrantFiled: December 28, 2015Date of Patent: July 4, 2017Assignee: Nitto Denko CorporationInventors: Kenjirou Minomi, Jens Harborth, Cima Cina, Kwok Yin Tsang, Wenbin Ying, Hirokazu Takahashi
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Publication number: 20170166898Abstract: This invention provides compounds, compositions and methods for modulating the expression of target genes using RNA interference. RNAi structures and molecules of this invention can be used for modulating or silencing the expression of genes, with high levels of RNAi activity and reduced off target actions. Advantageous structures include siRNAs targeted to any gene having one or more 2?-deoxy nucleotides located in the seed region. The RNA interference molecules can be used in methods for preventing or treating diseases.Type: ApplicationFiled: December 12, 2016Publication date: June 15, 2017Inventors: Kenjirou Minomi, Jens Harborth, Cima Cina, Wenbin Ying, Jane Zheng, Narendra Vaish
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Publication number: 20160208256Abstract: This invention provides compounds, compositions and methods for modulating the expression of human p21 using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.Type: ApplicationFiled: December 28, 2015Publication date: July 21, 2016Inventors: Yoshiro Niitsu, Kenjirou Minomi, Jens Harborth, Cima Cina, Kwok Yin Tsang, Wenbin Ying, Hirokazu Takahashi
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Patent number: RE49431Abstract: This invention provides compounds, compositions and methods for modulating the expression of human GST-? using RNA interference. The RNA interference molecules can be used in methods for preventing or treating diseases such as malignant tumor. Provided are a range of siRNA structures, having one or more of nucleotides being modified or chemically-modified. Advantageous structures include siRNAs with 2?-deoxy nucleotides located in the seed region, as well as other nucleotide modifications.Type: GrantFiled: August 11, 2020Date of Patent: February 28, 2023Assignee: NITTO DENKO CORPORATIONInventors: Kenjirou Minomi, Hirokazu Takahashi, Erika Terada, Jens Harborth, Jun Zhang, Mohammad Ahmadian, Wenbin Ying