Abstract: The invention relates to an endotoxin-binding lipopeptide selected from the group consisting of polymyxins, polymyxin derivatives, polymyxin analogues, prodrugs thereof and pharmaceutically acceptable salts thereof, and also relates to a preparation for parenteral administration comprising a lipopeptide of this type, for prophylaxis or for treatment of diseases and conditions caused by endotoxemia, by i) parenterally administering a bolus of the lipopeptide to achieve a lipopeptide serum concentration of 0.01 ?g/ml to 0.8 ?g/ml and ii) maintaining this lipopeptide serum concentration by parenterally administering the lipopeptide over a specifiable period of time.

Abstract: Embodiments of the invention relate to an extracorporeal perfusion apparatus comprising an extracorporeal blood circuit for conveying blood, a filtrate circuit for conveying blood plasma, and a controller, wherein the filtrate circuit is connected to the extracorporeal blood circuit by means of a filter, wherein the filter has a sieving coefficient of 5% for substances having a molar mass of 340,000 g/mol (relative molecular mass of 340 kDa), and wherein a depletion agent comprising a first carrier having a neutral, hydrophobic surface is arranged in the filtrate circuit, wherein the perfusion apparatus comprises a dispensing means for feeding an endotoxin-binding lipopeptide into the extracorporeal blood circuit, wherein the endotoxin-binding lipopeptide is selected from the group consisting of polymyxins, polymyxin derivatives, prodrugs thereof, and a combination thereof.

Abstract: A support structure component is provided for a motor vehicle body and to a correspondingly configured motor vehicle body. The support structure component includes, but is not limited to a support element and a plastic fastening structure arranged thereon, which includes, but is not limited to a fastening element for fastening a motor vehicle component.

Abstract: Blood purification device (100,200) having an extracorporeal blood circuit (102,202) with a blood inflow (103,203) to a dialysis unit (105,205) for blood removed from a patient and a blood outflow (104,204) from the dialysis unit (105,205) for blood being guided back into the patient, wherein the dialysis unit (105,205) comprises an inflow (107,207) for a dialysis solution and a dialysate outflow (108,208), characterised by a control loop for closed-loop control of the acid-base equilibrium of the blood, wherein bicarbonate is supplied to the blood by means of an aqueous bicarbonate-containing solution, wherein at least one measuring means (124,124a,224,224a) for measuring a blood buffer parameter is associated with the control loop, wherein the blood buffer parameter is selected from the group consisting of bicarbonate concentration and CO2 partial pressure, and wherein a signal corresponding to the measured actual value of the blood buffer parameter can be supplied to a closed-loop control apparatus (125,22

Abstract: A frame structure for a motor vehicle is disclosed which includes a side member, a bumper cross member, a first crash box arranged in extension of the side member and a second crash box, which obliquely branches off to the side from the arrangement of side member and first crash box. The bumper cross member protrudes over the first crash box towards the side, and an outer end of the second crash box is fastened to the bumper cross member.

Abstract: A bumper arrangement includes a bumper cross member, at least one crash box, which extends in a longitudinal direction and of which a front end is fastened to the bumper cross member, at least one support element extending along an outside of the crash box obliquely to the longitudinal direction, and a connection portion (8, 9), which is anchored on the crash box and at least on a with respect to the longitudinal direction middle region of the support element.

Abstract: A support structure component is provided for a motor vehicle body and to a correspondingly configured motor vehicle body. The support structure component includes, but is not limited to a support element and a plastic fastening structure arranged thereon, which includes, but is not limited to a fastening element for fastening a motor vehicle component.

Abstract: The invention relates to a sorption agent for removing endotoxins from a biological fluid, comprising a water-insoluble, porous carrier having a neutral hydrophobic surface wherein the surface of the carrier has an adsorptive coating made of polymyxin and albumin, wherein polymyxin and albumin are bonded to the surface of the carrier in a noncovalent manner. The invention further relates to a method for producing such a sorption agent. The sorption agent is used in extracorporeal blood purification, in particular in order to treat individuals, who have sepsis.

Abstract: A motor vehicle with a crashbox is provided. The motor vehicle includes a side member, a bumper, and a crashbox that connects the bumper to the side member. A wall of the crashbox in section along a section plane extending in longitudinal direction of the crashbox has waves. The amplitude of the waves in longitudinal direction of the crashbox is variable.

Abstract: A frame structure is provided for the underbody of a self-supporting motor vehicle bodywork. The frame structure includes, but not included with an elongate tunnel and two sillboards parallel hereto. The sillboards are disposed on both sides of the tunnel. The frame structure also includes, but is not limited to a dashboard cowl with closing plate, which is connected directly to both sillboards and the tunnel, a wheel housing with a downwardly open main structural arc, the ends whereof are connected to the underbody, and on its side facing the underbody (e.g., the vehicle inner side) the main structural arc has a damper receptacle in its upper area, from which a supporting strut connected to the underbody projects downward.

Abstract: A frame structure is provided for the underbody of a self-supporting motor vehicle bodywork. The frame structure includes, but not included with an elongate tunnel and two sillboards parallel hereto. The sillboards are disposed on both sides of the tunnel. The frame structure also includes, but is not limited to a dashboard cowl with closing plate, which is connected directly to both sillboards and the tunnel, a wheel housing with a downwardly open main structural arc, the ends whereof are connected to the underbody, and on its side facing the underbody (e.g., the vehicle inner side) the main structural arc has a damper receptacle in its upper area, from which a supporting strut connected to the underbody projects downward.

Abstract: A rear floor arrangement as well as a frame structure of an automotive body are provided having at least one first supporting structure component, which may be disposed in the inner or dry region of the motor vehicle and which may be directly connected to a second supporting structure component and inside the inner or dry region of the vehicle, which is mounted ahead of the first supporting structure component in the direction of travel and which extends at least in certain areas over a floor middle of the body.

Abstract: A rear floor arrangement as well as a frame structure of an automotive body are provided having at least one first supporting structure component, which may be disposed in the inner or dry region of the motor vehicle and which may be directly connected to a second supporting structure component and inside the inner or dry region of the vehicle, which is mounted ahead of the first supporting structure component in the direction of travel and which extends at least in certain areas over a floor middle of the body.

Abstract: The invention relates to a sorption agent having improved selectivity properties for removing protein-bound substances from a biological fluid, in particular blood or blood plasma of patients having severe disturbances of the liver function or liver failure and having kidney insufficiency, the sorption agent having: (a) a porous, neutral, hydrophobic polymer and (b) a polypeptide layer adsorbed on the polymer, the neutral, hydrophobic polymer having a mean pore size of at least 15 nm. Furthermore, the invention relates to methods and uses in connection with such a sorption agent. The invention is used in particular in extracorporeal liver support.

Abstract: A front structure for a motor vehicle with an upper and with a lower load path has a modular component. The modular component includes, but is not limited to a cross member for connecting of ends of side members of the lower load path facing in driving direction and a radiator member for holding a radiator of a combustion engine of the motor vehicle. The front structure because of this can be produced particularly cost-effectively and is constructed in a particularly simple manner.

Abstract: The invention relates to a device for the citrate anti-coagulated extracorporeal blood purification comprising: an extracorporeal blood purification system comprising an extracorporeal blood circuit (202), which comprises a dialysis unit (205), a blood inflow (203) and a blood discharge (204), a citrate metering device (212) for supplying citrate at a citrate supply point (213) upstream of the dialysis unit (205), a substitution medium metering device (214) for supplying a substitution medium at a substitution medium supply point (215) downstream from the dialysis unit (205), at least one ion concentration measuring means (224) for measuring bivalent cations and a controller (225), wherein the controller (225) is adapted to regulate the metering of the substitution medium as a function of a comparison between a setpoint value range and the ion concentration measured by means of the ion concentration measuring means (224), wherein the ion concentration measuring means (224) is adapted for the continuous genera

Abstract: A rear frame for a motor vehicle has a profile part manufactured from cast metal. The profile part has two legs, which are connected to one another via a cover element, and an attachment element. In this way, the rear frame has a particularly high stability and may be manufactured particularly cost-effectively.

Abstract: A rear floor arrangement as well as a frame structure of an automotive body are provided having at least one first supporting structure component, which may be disposed in the inner or dry region of the motor vehicle and which may be directly connected to a second supporting structure component and inside the inner or dry region of the vehicle, which is mounted ahead of the first supporting structure component in the direction of travel and which extends at least in certain areas over a floor middle of the body.

Abstract: A rear frame for a motor vehicle has a profile part manufactured from cast metal. The profile part has two legs, which are connected to one another via a cover element, and an attachment element. In this way, the rear frame has a particularly high stability and may be manufactured particularly cost-effectively.

Abstract: A well servicing composition containing an aqueous phase and an oil phase and an ether carboxylic acid of the formula: RO(CH2CH2O)x(CH2CHR1O)yCH2—COOX wherein, R is a saturated or unsaturated, branched or unbranched alkyl or alkenyl group containing 6 to 22 carbon atoms, x is a number from 1 to 20 and y is 0 or a number from 1 to 20, provided that the sum of x and y is at least 1 and at most 25, R1 is an alkyl group containing 1 to 4 carbon atoms and X comprises at least one member selected from the group consisting of a hydrogen atom, monovalent cations and polyvalent cations.