Abstract: An injection capsule for medical use, having: a closed main body having an internal reservoir receiving a medical substance in liquid form to be administered to a target subject; and a needle, having one or more inlet bores located at its lateral skirt and configured to allow the inlet of the medical substance within its tubular body. The needle is activatable between a rest configuration, wherein it is housed within the reservoir and immersed in the medical substance, and an injection configuration, wherein it is pushed outside the closed main body to administer the medical substance by injection to the target subject.

Abstract: The present invention relates to electronically assisted drug delivery devices (100). The drug delivery device may include a Gray code type detector for sensing dosage data, wherein the detector comprises a code track consisting of a sequence of alternating markings and a plurality of detectors that are mutually spaced in a direction extending along the code track. The drug delivery device may also include a dosage selector (260) which is moved in a proximal direction upon dose setting and in a distal direction upon dose injection, where the dosage selector is latched in the end of dose position by a latching element, the latching element actuating an end of dose switch for signalling the end of dose state. The drug delivery device may also incorporate power-management arrangements which effectively minimizes power consumption for the incorporated electronic circuitry.

Abstract: Novel recombinant allergens with multiple mutations and reduced IgE binding affinity are disclosed. The allergens are mutants of naturally occurring allergens. The overall ?-carbon backbone tertiary structure is essentially preserved. Also disclosed is a method for preparing such recombinant allergens as well as uses thereof.

Abstract: The present invention relates to novel recombinant protein variants that are useful as immunotherapeutic components. Also the present invention relates to DNA sequences encoding said protein variants as well as compositions comprising said protein variants.

Abstract: The present invention relates to novel recombinant protein variants that are useful as immunotherapeutic components. Also the present invention relates to DNA sequences encoding said protein variants as well as compositions comprising said protein variants.

Abstract: A funnel for pouring liquid into a receptacle is collapsible and is stored in the receptacle when not in use. The funnel is automatically unfolded upon opening the receptacle lid. The funnel has no risk of is unfolding in the receptacle. A tube fixed to the base plate includes displaceable means that are fastened to the lid. The tube is terminated at the top with an arrester for securing the displaceable means. The foldable funnel is disposed inside the existing receptacle, and the funnel is unfolded as soon as the lid is lifted. The opened lid is disposed at the side of the funnel completely outside the funnel circumference so as not to interfere with filling. Placing the lid upon the tube, centering the lid on the funnel and pushing downward closes the receptacle and folds the funnel, which disappears downward into the receptacle.

Abstract: The present invention relates to novel recombinant protein variants that are useful as immunotherapeutic components. Also the present invention relates to DNA sequences encoding said protein variants as well as compositions comprising said protein variants.

Abstract: Novel recombinant allergens with multiple mutations and reduced IgE binding affinity are disclosed. The allergens are mutants of naturally occurring allergens. The overall &agr;-carbon backbone tertiary structure is essentially preserved. Also disclosed is a method for preparing such recombinant allergens as well as uses thereof.

Abstract: Novel recombinant allergens with multiple mutations and reduced IgE binding affinity are disclosed. The allergens are non-naturally occurring mutants of naturally-occurring allergens. The overall &agr;-carbon backbone tertiary structure is essentially preserved. Also disclosed is a method for preparing such recombinant allergens as well as uses thereof.