Patents by Inventor Jens Perregaard
Jens Perregaard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7329291Abstract: Process for production of synthesis gas comprising carbon monoxide, carbon dioxide and hydrogen by reforming of methanol including the steps of: (a) introducing methanol in liquid phase into a reactor containing a solid methanol reforming catalyst suspended in a liquid phase of methanol and water; (b) reacting the liquid phase of methanol and water in presence of the suspended catalyst at a pressure and temperature, where methanol is maintained in the liquid phase; and (c) withdrawing from the reactor a gas phase of synthesis gas being produced during reaction of the liquid methanol and water phase.Type: GrantFiled: November 17, 2004Date of Patent: February 12, 2008Assignee: Haldor Topsoe A/SInventors: Poul Erik Højlund Nielsen, Jens Perregaard
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Patent number: 7087801Abstract: A reactor system for oxidative conversion of hydrocarbons comprising at least one reactor tube being provided with a plurality of perforations along a wall of the tube and a reaction zone with an active catalyst arranged on tube side and/or shell side of the reactor tube; and a bed of particulates material surrounding the at least one reactor tube, the bed of particulate material being adapted to be fluidised by an oxygen containing atmosphere and to transport heat from the reactor tube.Type: GrantFiled: October 17, 2003Date of Patent: August 8, 2006Assignee: Haldor Topsoe A/SInventors: Jens Perregaard, Gregory Patience
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Publication number: 20050108941Abstract: Process for production of synthesis gas comprising carbon monoxide, carbon dioxide and hydrogen by reforming of methanol including the steps of: (a) introducing methanol in liquid phase into a reactor containing a solid methanol reforming catalyst suspended in a liquid phase of methanol and water; (b) reacting the liquid phase of methanol and water in presence of the suspended catalyst at a pressure and temperature, where methanol is maintained in the liquid phase; and (c) withdrawing from the reactor a gas phase of synthesis gas being produced during reaction of the liquid methanol and water phase.Type: ApplicationFiled: November 17, 2004Publication date: May 26, 2005Inventors: Poul Nielsen, Jens Perregaard
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Patent number: 6881759Abstract: The present invention is a novel process for methanol production in a liquid phase reactor from a synthesis gas comprising of hydrogen, carbon dioxide and carbon monoxide. The liquid phase reactor contains a solid catalyst suspended in methanol. In this innovation, methanol acts both as a product and as a suspension medium for the catalyst. The new innovation exploits the condensing conditions for methanol production. By operating at condensing conditions, the methanol partial pressure at equilibrium is higher than the boiling pressure of methanol at the given temperature. Hence the produced methanol of the equilibrium composition condenses creating the potential of more gas to be converted. Since equilibrium is not a limiting factor, high conversions can be obtained.Type: GrantFiled: March 23, 2004Date of Patent: April 19, 2005Assignee: Haldor Topsoe A/SInventors: Poul Erik Højlund Nielsen, Cecilia Jaksland, Jens Perregaard
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Publication number: 20040198847Abstract: The present invention is a novel process for methanol production in a liquid phase reactor from a synthesis gas comprising of hydrogen, carbon dioxide and carbon monoxide. The liquid phase reactor contains a solid catalyst suspended in methanol. In this innovation, methanol acts both as a product and as a suspension medium for the catalyst. The new innovation exploits the condensing conditions for methanol production. By operating at condensing conditions, the methanol partial pressure at equilibrium is higher than the boiling pressure of methanol at the given temperature. Hence the produced methanol of the equilibrium composition condenses creating the potential of more gas to be converted. Since equilibrium is not a limiting factor, high conversions can be obtained.Type: ApplicationFiled: March 23, 2004Publication date: October 7, 2004Inventors: Poul Erik Hojlund Nielsen, Cecilia Jaksland, Jens Perregaard
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Publication number: 20040082671Abstract: A reactor system for oxidative conversion of hydrocarbons comprising at least one reactor tube being provided with a plurality of perforations along a wall of the tube and a reaction zone with an active catalyst arranged on tube side and/or shell side of the reactor tube; and a bed of particulate material surrounding the at least one reactor tube, the bed of particulate material being adapted to be fluidised by an oxygen containing atmosphere and to transport heat from the reactor tube.Type: ApplicationFiled: October 17, 2003Publication date: April 29, 2004Inventors: Jens Perregaard, Gregory Patience
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Patent number: 6515146Abstract: Process for the oxidation of a hydrocarbon substrate to a corresponding oxidised hydrocarbon compound by contacting the hydrocarbon substrate with an oxygen containing atmosphere in presence of a catalyst being active in the oxidation of the hydrocarbon substrate, which process comprises the steps of: passing a process gas containing the hydrocarbon substrate through a reaction zone with the catalyst; introducing the oxygen containing atmosphere divided into a plurality of substreams successively into the reaction zone; within the reaction zone reacting the process gas continuously with the oxygen containing atmosphere; and withdrawing from the reaction zone a product gas containing oxidised hydrocarbon compound and carbon monoxide.Type: GrantFiled: September 1, 2000Date of Patent: February 4, 2003Assignees: Haldor Topsoe A/S, University of Zaragoza, Du Pont Iberia, S.A.Inventors: Jens Perregaard, Jesus Santamaria, Miquel Menendes, Reyes Mallada, Gregory Patience, Julian R. H. Ross, Erzeng Xue, Jean-Claude Volta, Anne Julbe, David Furrusseng
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Patent number: 6326523Abstract: Process for the dehydrogenation of a hydrocarbon feed comprising a step of dehydrogenating the hydrocarbon feed and a step of removing hydrogen being formed by dehydrogenation reactions, wherein the dehydrogenation and hydrogen removal steps are performed simultaneously in presence of a dehydrogenation catalyst being combined with a metal compound being reduced in presence of hydrogen.Type: GrantFiled: March 28, 2000Date of Patent: December 4, 2001Assignee: Haldor Topsoe A/SInventors: Anni Stahl, Niels Jørgen Blom, Jens Perregaard, Poul Erik Højlund Nielsen
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Patent number: 6140331Type: GrantFiled: December 24, 1997Date of Patent: October 31, 2000Assignee: H. Lundbeck A/SInventors: Ejner K. Moltzen, Jens Perregaard, Henrik Pedersen
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Patent number: 6090808Abstract: This subject invention relates to dimeric 4-phenylpiperidine, 4-phenyl-1,2,3,6-tetrahydropyridine, or 4-phenylpiperazine compounds or dimeric spirocyclic piperidine compounds having general formula (I), ##STR1## wherein n is 1-5; R.sup.1 to R.sup.4 are substituents; R.sup.5 and R.sup.6 each hydrogen or alkyl or form together an ethylene or propylene bridge; X is O, S, SO, SO.sub.2, CO or (CH.sub.2).sub.m, m being 0 or 1, X is NR.sup.7, R.sup.7 being H, alkyl, cycloalkyl, cycloalkylalkyl, phenyl, or phenylalkyl, or X is CR.sup.8-- R.sup.9, wherein R.sup.8 and R.sup.9 are selected from hydroxy and the substituents defined under R.sup.7 ; and (i) Z.sup.1 is a substituent and Z.sup.2 is (CH.sub.2).sub.p wherein p is 0; and Y is N, C or CH; (ii) Z.sup.1 and Y are linked together via a single bond, thereby forming a spirocyclic junction; in which case Y is C; Z.sup.1 is O, S, (CH.sub.2).sub.q, q being 1, 2 or 3, or Z.sup.1 is CH.sub.2 O, CH.sub.2 S, CH.sub.2 CH.sub.2 O, CH.sub.2 CH.sub.2 S, CH.dbd.CH, CH.dbd.CHCH.Type: GrantFiled: May 6, 1998Date of Patent: July 18, 2000Assignee: H. Lundbeck A/SInventors: Jens Perregaard, John W. Stenberg, Ejner K. Moltzen
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Patent number: 5972964Abstract: Compounds of formula I ##STR1## wherein R1.dbd.(cyclo)alk(en)yl, aralkyl, alkyl(oxy)carbonyl, CONH2, etc.; R2.dbd.H, (cyclo)alk(en)yl, aralkyl, etc.; R3-R5.dbd.H, halo, alkyl, alkoxy, etc.; R6,R7.dbd.H, alkyl; R6R7.dbd.atoms to complete a ring; R8,R9.dbd.groups cited for R2, 2-oxoimidazolidinoalkyl, etc.; NR8R9=heterocyclyl; 1 of X,Y=CH2 and the other.dbd.CH2, O, S were prepd. Thus, 1-indancarboxylic acid was converted in 5 steps to 1-(N,N-dipropylaminomethyl)-6-formylaminoindane oxalate which had ED50 of 0.0055.mu.M/kg s.c. in the 8--OH DPAT cue agonism test in rats.Type: GrantFiled: October 22, 1997Date of Patent: October 26, 1999Assignee: H. Lundbeck A/SInventor: Jens Perregaard
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Patent number: 5837707Abstract: This subject invention relates to dimeric 4-phenylpiperidine, 4-phenyl-1,2,3,6-tetrahydropyridine, or 4-phenylpiperazine compounds or dimeric spirocyclic piperidine compounds having general formula (I), ##STR1## wherein n is 1-5; R.sup.1 to R.sup.4 are substituents; R.sup.5 and R.sup.6 each hydrogen or alkyl or form together an ethylene or propylene bridge; X is O, S, SO, SO.sub.2, CO or (CH.sub.2).sub.m, m being 0 or 1, X is NR.sup.7, R.sup.7 being H, alkyl, cycloalkyl, cycloalkylalkyl, phenyl, or phenylalkyl, or X is CR.sup.8 R.sup.9, wherein R.sup.8 and R.sup.9 are selected from hydroxy and the substituents defined under R.sup.7 ; and (i) Z.sup.1 is a substituent and Z.sup.2 is (CH.sub.2).sub.p wherein p is 0; and Y is N, C or CH; (ii) Z.sup.1 and Y are linked together via a single bond, thereby forming a spirocyclic junction; in which case Y is C; Z.sup.1 is O, S, (CH.sub.2).sub.q, q being 1, 2 or 3, or Z.sup.1 is CH.sub.2 O, CH.sub.2 S, CH.sub.2 CH.sub.2 O, CH.sub.2 CH.sub.2 S, CH.dbd.CH, CH.dbd.CHCH.Type: GrantFiled: June 6, 1995Date of Patent: November 17, 1998Assignee: H. Lundbeck A/SInventors: Jens Perregaard, John W. Stenberg, Ejner K. Moltzen
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Patent number: 5830896Abstract: This subject invention relates to dimeric 4-phenylpiperidine, 4-phenyl-1,2,3,6-tetrahydropyridine, or 4-phenylpiperazine compounds or dimeric spirocyclic piperidine compounds having general formula (1), ##STR1## wherein n is 1-5; R.sup.1 to R.sup.4 are substituents; R.sup.5 and R.sup.6 each hydrogen or alkyl or form together an ethylene or propylene bridge; X is O, S, SO, SO.sub.2, CO or (CH.sub.2).sub.m, m being 0 or 1, X is NR.sup.7, R.sup.7 being H, alkyl, cycloalkyl, cycloalkylalkyl, phenyl, or phenylalklyl, or X is CR.sup.8--R.sup.9, wherein R.sup.8 and R.sup.9 are selected from hydroxy and the substituents defined under R.sup.7 ; and (i) Z.sup.1 is a substituent and Z.sup.2 is (CH.sub.2).sub.p wherein p is 0; and Y is N, C or CH; (ii) Z.sup.1 and Y are linked together via a single bond, thereby forming a spirocyclic junction; in which case Y is C; Z.sup.1 is O, S, (CH.sub.2).sub.q, q being 1, 2 or 3, or Z.sup.1 is CH.sub.2 O, CH.sub.2 S, CH.sub.2 CH.sub.2 O, CH.sub.2 CH.sub.2 S, CH.dbd.CH, CH.dbd.CHCH.Type: GrantFiled: June 7, 1995Date of Patent: November 3, 1998Assignee: H. Lundbeck A/SInventors: Jens Perregaard, John W. Stenberg, Ejner K. Moltzen
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Patent number: 5753661Abstract: Fused benzo compounds of formula I are provided, wherein A is a 2 to 6 membered hydrocarbon spacer group, B is a polar divalent group selected from a group (a); U is C, N or CH; X is a divalent 3-4 membered chain optionally comprising one or more heteroatoms; R.sup.1 is an aliphatic hydrocarbon group, arylalkyl or diphenylalkyl; R.sup.2 and R.sup.3 are hydrogen or alkyl or together form an ethylene or propylene bridge; R.sup.4, R.sup.5 and R.sup.6 are hydrogen or substituents; R.sup.7 and R.sup.8 are hydrogen or substituents including --COOR.sup.9 and --CONR.sup.10 R.sup.11 ; are 5-HT.sub.1A receptor ligands useful in the treatment of CNS disorders. Pharmaceutical compositions comprising the compounds and their use for the manufacture of a pharmaceutical preparation are also provided.Type: GrantFiled: June 6, 1995Date of Patent: May 19, 1998Assignee: H. Lundbeck A/SInventors: Ejner K. Moltzen, Jens Perregaard, Henrik Pedersen
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Patent number: 5684012Abstract: This subject invention relates to dimeric 4-phenylpiperidine, 4-phenyl-1,2,3,6-tetrahydropyridine, or 4-phenylpiperazine compounds or dimeric spirocyclic piperidine compounds having general formula (I), ##STR1## wherein n is 1-5; R.sup.1 to R.sup.4 are substituents; R.sup.5 and R.sup.6 each hydrogen or alkyl or form together an ethylene or propylene bridge; X is O, S, SO, SO.sub.2, CO or (CH.sub.2).sub.m, being 0 or 1, X is NR.sup.7, R.sup.7 being H, alkyl, cycloalkyl, cycloalkylalkyl, phenyl, or phenylalkyl, or X is CR.sup.8 R.sup.9, wherein R.sup.8 and R.sup.9 are selected from hydroxy and the substituents defined under R.sup.7 ; and (i) Z.sup.1 is a substituent and Z.sup.2 is (CH.sub.2).sub.p wherein p is 0; and Y is N, C or CH; (ii) Z.sup.1 and Y are linked together via a single bond, thereby forming a spirocyclic junction; in which case Y is C; Z.sup.1 is O, S, (CH.sub.2).sub.q, q being 1, 2 or 3, or Z.sup.1 is CH.sub.2 O, CH.sub.2 S, CH.sub.2 CH.sub.2 O, CH.sub.2 CH.sub.2 S, CH.dbd.CH, CH.dbd.CHCH.sub.Type: GrantFiled: June 7, 1995Date of Patent: November 4, 1997Assignee: H. Lundbeck A/SInventors: Jens Perregaard, John W. Stenberg, Ejner K. Moltzen
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Patent number: 5658921Abstract: The subject invention describes Novel dimer 4-phenylpiperidine, 4-phenyl-1,2,3,6-tetrahydropyridine, or 4-phenylpiperazine compounds or dimeric spirocyclic piperidine compounds having the general Formula I: ##STR1## wherein n is 1-5;R.sup.1 to R.sup.4 are independently selected from hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, hydroxy, C.sub.1-6 alkylthio, C.sub.1-6 alkylsulfonyl, C.sub.1-6 alkyl- or di-(C.sub.1-6 alkyl)amino, cyano, trifluoromethyl, nitro, trifluoromethylthio or trifluoromethylsulfonyloxy; R.sup.5 and R.sup.6 are independently hydrogen, or C.sub.1-6 alkyl;X is O, S, SO, SO.sub.2, CO or (CH.sub.2).sub.m, m being 0 or 1, or X is NR.sup.7, R.sup.7 being H, C.sub.1-6 alkyl, cycloalkyl, cycloalkylalkyl, phenyl, or phenylalkyl, or X is CR.sup.8 R.sup.9, wherein R.sup.8 and R.sup.9 are independently selected from the group consisting of hydroxy and the substituents defined under R.sup.7, any phenyl group being optionally substituted with one or more substituents selected from halogen, C.Type: GrantFiled: December 12, 1994Date of Patent: August 19, 1997Assignee: H. Lundbeck A/SInventors: Jens Perregaard, John W. Stenberg, Ejner K. Moltzen
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Patent number: 5238945Abstract: Disclosed is a method of treating psychoses in human beings, comprising the step of administering an effective amount of the compound, ##STR1## or a pharmaceutically acceptable salt thereof, to a patient in need thereof.Said compound selectively blocks dopamine neurones in the ventral tegmental area of the brain, substantially without blocking the dopamine neurones in the substantia nigra pars compacta and, therefore, is free from the extrapyramidal side effects of common neuroleptics.Type: GrantFiled: April 30, 1992Date of Patent: August 24, 1993Assignee: H. Lundbeck A/SInventors: Jens Perregaard, Torben Skarsfeldt
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Patent number: 5112838Abstract: A method of treating psychoses in human beings with the atypical neuroleptic 5-chloro-1-(4-fluorophenyl)-3-(1-(2-(2-imidazolidinon-1-yl) ethyl-4-piperidyl)-1H-indole, having the formula: ##STR1## or a pharmaceutically-acceptable salt thereof, thereby to selectively block dopamine neurones in the ventral tegmental area of the brain, substantially without blocking dopamine neurones in the substantia nigra pars compacta, and therefore without the usual extrapyramidal side effects of common neuroleptics, is disclosed.Type: GrantFiled: April 11, 1990Date of Patent: May 12, 1992Assignee: H. Lundbeck A/SInventors: Jens Perregaard, Torben Skarsfeldt
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Patent number: 5002948Abstract: The present invention relates to novel piperazinylbutylindoles, -indazoles, the corresponding 2,3-dihydro derivatives and 2-indolones which have been found to have central serotonin activity with preference for the serotonin 5-HT.sub.lA receptor.Compared to the anxiolytic drug buspirone, and other clinically investigated compounds such as ipsapirone and gepirone, most of the present compounds have lower efficacy at the 5-HT.sub.lA receptor which implies less side effects related to activation of the receptors.The invention also includes acid addition salts, methods of preparation, pharmacetical compositions and method of treating CNS disorders occuring in anxiety, depression, aggression and in alcohol abuse, or in states of disease related to the cardiovascular, gastrointestinal and renal systems, by administering the aforementioned derivatives.Separation and use of the stereo isomers of the 2,3-dihydro derivatives and 2-indolones are also part of this invention.Type: GrantFiled: December 26, 1989Date of Patent: March 26, 1991Assignee: H. Lundbeck A/SInventors: Jens Perregaard, John W. Stenberg
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Patent number: 4943590Abstract: The two enantiomers of the anti-depressant drug of the formula I ##STR1## are disclosed. Methods for resolving intermediates and their steroselective conversion to a corresponding enatiomer of I are also disclosed.Type: GrantFiled: June 8, 1989Date of Patent: July 24, 1990Assignee: H. Lundbeck A/SInventors: Klaus P. Boegesoe, Jens Perregaard