Abstract: The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of diseases such as liver disease.

Abstract: A method of providing a cleaned gas diffusion layer for electrochemical applications includes providing a gas diffusion layer such that a first side of the gas diffusion layer is arranged on a first vacuum conveyor belt, cleaning an exposed second side of the gas diffusion layer, the second side being situated opposite the first side of the gas diffusion layer, transferring the partially cleaned gas diffusion layer to a second vacuum conveyor belt partially situated opposite the first vacuum conveyor belt, wherein the first vacuum conveyor belt and the second vacuum conveyor belt have a transfer region in which the gas diffusion layer is transferred from the first vacuum conveyor belt to the second vacuum conveyor belt such that the first side of the gas diffusion layer is exposed, and cleaning the first side of the gas diffusion layer.

Abstract: A membrane electrode assembly includes a cathode, an anode and a proton-conductive membrane, wherein the cathode includes a first metal-containing catalyst and a proton-conductive ionomer, the anode includes a proton-conductive ionomer, a second metal-containing catalyst that catalyzes the reaction of hydrogen to protons, and a third metal-containing catalyst that catalyzes the reaction of CO to CO2, a total mass ratio of platinum of the second catalyst and platinum of the third catalyst to a total mass ratio of metals of the second catalyst and the third catalyst, with the exception of platinum, is greater than 3:1, and the total mass per unit area of platinum of the second catalyst and platinum of the third catalyst is less than 0.4 mg/cm2.

Abstract: Methods are provided herein for determining and administering optimized dosing of therapeutic anti-D47 agents, in a schedule that provides safe escalation of dose while achieving a therapeutic level in a clinically effective period of time. The methods can comprise the steps of clearance, escalation, and maintenance. In one embodiment the dosing regimen administers an initial (i) sub-therapeutic dose of an anti-CD47 agent or (ii) a cytoreductive therapy to achieve a safe level of circulating tumor cells for subsequent treatment (clearance); escalating the dose of an anti-CD47 agent until a therapeutic dose is reached (escalation); and maintaining the therapeutic dose for a period of time sufficient to reduce tumor cells in the bone marrow of the patient (maintenance). In an alternative dosing regimen, a patient determined to have a safe level of circulating tumor cells at presentation is treated by the steps of escalation and maintenance without initial clearance.

Abstract: A silicon carbide device includes: a transistor cell having a stripe-shaped trench gate structure extending from a first surface into a silicon carbide body, the gate structure having a gate length along a lateral first direction, a bottom surface and a first gate sidewall of the gate structure being connected via a first bottom edge of the gate structure; at least one source region of a first conductivity type in contact with the first gate sidewall; and a shielding region of a second conductivity type in contact with the first bottom edge of the gate structure across at least 20% of the gate length. No source regions of the first conductivity type are in contact with a second gate sidewall of the gate structure.

Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.

Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.

Abstract: A computer-implemented method for generating a 2D or 3D object, including training an autoencoder on a first set of training data to identify a first set of latent variables and generate a first set of output data; training an hourglass predictor on a second set of training data, where the hourglass predictor encoder converts a set of related but different training input data to a second set of latent variables, which decode into a second set of output data of the same type as the first set of output data; and using the hourglass predictor to predict a 2D or 3D object of the same type as the first set of output data based on a 2D or 3D object of the same type as the second set of input data.

Abstract: Methods for capturing temporary database tables for analyzing a database query are provided. Aspects include obtaining a capture pattern and the database query having a sequence of statements. Aspects also include determining that a first statement of the sequence of statements matches the capture pattern, creating a list of temporary tables based on the first statement, and determining that a second statement of the sequence of statements includes one of a drop, commit, and truncate commands that correspond to a table in the list of temporary tables. Aspects further include creating a copy of the table in the list of temporary tables, generating an updated first statement by replacing a reference to the table in the list of temporary tables with a reference to the copy of the table, removing the table from the list of temporary tables, and executing the database query by performing the sequence of statements.

Abstract: A medical diagnosis assistance system, a medical diagnosis assistance method, and a training method for training an artificial intelligence entity are disclosed. The medical diagnosis assistance system includes: an input interface configured to receive medical image data of a patient; a computing device configured to implement: a classification module configured to classify parts of interest, POI, comprising objects of interest, OOI, and/or regions of interest, ROI, within the received medical image data, and to assign a corresponding reliability metric to each of the classified POI; and an analysis module configured to determine, based on the POI and the assigned reliability metric, an analysis of the medical image data; and an output interface configured to output an output signal indicating the analysis.

Abstract: Methods are provided for targeting cells for depletion, including without limitation cancer cells, in a regimen comprising contacting the targeted cells with a combination of immunoregulatory agents. The level of depletion of the targeted cell is enhanced relative to a regimen in which a single agent is used; and the effect may be synergistic relative to a regimen in which a single agent is used.

Abstract: A working apparatus has a manual operating region, a tubular part extending away from the manual operating region, and an electric cable arrangement in the tubular part. The working apparatus includes a rod-shaped cable holder, which is inserted into and held in the tubular part and has a cable holding arrangement, by which the cable arrangement is held in a pre-mounted manner on the cable holder. An assembly method secures the cable arrangement on the cable holder by the cable holding arrangement, and inserts the cable holder, with the cable arrangement held thereon, into the tubular part. The working apparatus may be a battery-operated, hand-guided garden or forestry working apparatus.

Abstract: An automated laboratory system includes a work area with a plurality of predefined workstations. Each of the plurality of predefined workstations occupies a footprint of a standardized microtiter plate. At least one tool holder is structured to move tools above the work area and at least one transport tool is structured to be moved by the tool holder in order to relocate laboratory items within the work area. At least one pipetting tool is structured to be moved by the tool holder in order to pick up and release pipette tips. A holder for pipette tip carriers includes at least one carrying apparatus defining a rectangular through-opening, and a support apparatus connected to the carrying apparatus. An electronic control apparatus is connected to the tool holder and structured to control movements of the transport tool and at least one pipetting tool by the tool holder.

Abstract: Methods are provided herein for determining and administering optimized dosing of therapeutic anti-CD47 agents, in a schedule that provides safe escalation of dose while achieving a therapeutic level in a clinically effective period of time. The methods can comprise the steps of clearance, escalation, and maintenance. In one embodiment the dosing regimen administers an initial (i) sub-therapeutic dose of an anti-CD47 agent or (ii) a cytoreductive therapy to achieve a safe level of circulating tumor cells for subsequent treatment (clearance); escalating the dose of an anti-CD47 agent until a therapeutic dose is reached (escalation); and maintaining the therapeutic dose for a period of time sufficient to reduce tumor cells in the bone marrow of the patient (maintenance). In an alternative dosing regimen, a patient determined to have a safe level of circulating tumor cells at presentation is treated by the steps of escalation and maintenance without initial clearance.

Abstract: The specification relates to compounds of Formula (I): and to pharmaceutically acceptable salts thereof, to processes and intermediates used for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of diseases such as liver disease.

Abstract: A loudspeaker system (700 or 800) and method for tuning ported loudspeakers and reducing unwanted acoustic resonances provides reduced port noise, eliminates undesired port resonances and improves the accuracy and fidelity of reproduced sound in a loudspeaker system of relatively high efficiency with an enclosure including an Eigen Tone Filter structure (“ETF”) comprising a pipe or set of pipes 720, 820 placed inside a loudspeaker vent to absorb the “open pipe” acoustic resonance of the vent. The open-pipe resonance is unwanted and interferes with the midrange performance of the loudspeaker, when in use, if not corrected.

Abstract: The present disclosure relates to a method for detecting alarm objects in items of luggage using a primary detection system and a secondary detection system, having the following steps: carrying out a primary detection method by means of the primary detection system to detect at least one alarm object, transferring at least one alarm object parameter (AP) to the secondary detection system in the event of an alarm object being detected in the primary detection method, adapting at least one detection parameter (DP) of the secondary detection system on the basis of the alarm object parameter (AP), carrying out a secondary detection method by means of the secondary detection system with adapted at least one detection parameter (DP) in order to check the alarm object detected in the primary detection method, and outputting an alarm signal (AS) in the event that the checking of the alarm object proves positive.

Abstract: A transformable modular toy element is provided. The transformable modular toy element is for use in a toy construction system comprising a plurality of modular toy elements. The transformable modular toy element comprises a body portion and a head portion. The body portion comprises one or more coupling members, the one or more coupling members being adapted for releasably coupling the body portion with modular toy elements of the toy construction system. The head portion is attached to the body portion. The head portion comprises a cavity for receiving the body portion therein. The body portion is moveable with respect to the head portion between a retracted position where the body portion is retracted into the cavity, whereby the transformable modular toy element has a first shape, and a deployed position where the body portion is in the axial direction deployed from the cavity, whereby the transformable modular toy element has a second shape.

Abstract: The invention relates to a first and a second method for the efficient, automated, exact and cost-efficient production of multi-layer continuous webs of membrane electrode assemblies which are suitable for the use in fuel cells, water electrolysis cells, electrochemical compressors and electrochemical sensors.

Abstract: Provided is a system for muscle strength support. The system includes an exoskeleton which is configured to be attached to a body of a human during use of the system, and a control unit for controlling a supportive force provided by the exoskeleton during use of the system.