Abstract: Methods, kits, and compositions are provided herein that can be used to treat ovarian cancer using an anti-CD47 antibody. The anti-CD47 antibody can be used alone or in combination with one or more additional agent such as chemotherapy.

Abstract: A silicon carbide device includes: a transistor cell having a stripe-shaped trench gate structure extending from a first surface into a silicon carbide body, the gate structure having a gate length along a lateral first direction, a bottom surface and a first gate sidewall of the gate structure being connected via a first bottom edge of the gate structure; at least one source region of a first conductivity type in contact with the first gate sidewall; and a shielding region of a second conductivity type in contact with the first bottom edge of the gate structure across at least 20% of the gate length. No source regions of the first conductivity type are in contact with a second gate sidewall of the gate structure.

Abstract: The present invention primarily relates to a process for production of one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulphuric compounds, the process comprising providing a culture medium comprising one or more components supporting growth of a fungus from the phylum Basidiomycota and being convertable to one or more flavourings selected from the group consisting of non-saturated aldehydes, non-saturated lactones and organosulfur aroma compounds; cultivating a fungus from the phylum Basidiomycota in or on the culture medium under conditions that support the growth of the fungus and formation of the one or more flavourings, and optionally recovering the one or more flavourings.

Abstract: The present disclosure is directed to reducing nocturnal voids by administering a dose of desmopressin over a minimum treatment period compared to before administration, and maintaining or improving the reduction of nocturnal voids over the minimum treatment period.

Abstract: A method for generating a copy of a database using a data streaming protocol is disclosed. The method comprises setting up a structure of a secondary database, prioritizing data objects to be copied from a primary database to the secondary database, copying data objects from the primary database to the secondary database using a data streaming protocol, restoring data corresponding to the data object in the secondary database in parallel to copying data objects from the primary database to the secondary database, applying changes made to the data corresponding to the data object in the primary database during the time of copying, after the data object has been copied, and making available the secondary database for usage once all data objects have been copied from the primary database to the secondary database so that a usable copy of the primary database is created.

Abstract: The present disclosure generally relates to compositions and methods simultaneous, multi-mode gene expression regulation (e.g., simultaneous upregulation and down regulation of multiple target genes). The present disclosure further relates to novel constructs for engineered multiplex CRISPR arrays.

Abstract: A tool arrangement for forming a tunnel in a vertebra to perform nerve ablation includes a tamp having a distal end portion that includes a tip for creating the tunnel in the vertebra and a curvable portion to direct the tip along a curved path within the vertebra; a first cannula including a cannula body that is straight along an entire length of the cannula body and configured to receive the curvable portion of the tamp and straighten the curvable portion; and a tool hub including a stationary cannula attachment coupled to the first cannula and a movable head coupled to the tamp and configured to move toward or away from the stationary cannula attachment to extend or retract, respectively, the curvable portion of the tamp from or into, respectively, the first cannula.

Abstract: The disclosure relates to a specifically static mixer for mixing two components, with a housing, in which a mixing element is accommodated, and an input part with a first intake and a diametrically opposite second intake, wherein, within the input part, a first channel is formed between the first intake and the mixing chamber and a second channel is formed between the second intake and the mixing chamber. The first channel extends radially inward from the first intake and opens into a central opening in the cover. The second channel has two partial channels as storage chambers not leading into the mixing chamber, and two intake sections located radially within the storage chambers and leading into the mixing chamber. The intake sections branch off the respective storage chambers, extend inward in the opposite direction to the first channel and open into the central opening in the cover.

Abstract: A field effect transistor (FET) is proposed. The FET includes a transistor cell area in a silicon carbide (SiC) semiconductor body. An edge termination area surrounds the transistor cell area. A source contact is arranged over a first surface of the SiC semiconductor body. A drain contact is arranged on a second surface of the SiC semiconductor body. The FET further includes a drift region of a first conductivity type between the first surface and the second surface. Along a lateral direction, a net doping concentration in the drift region is larger in the transistor cell area than in the edge termination area.

Abstract: Therapeutic and diagnostic methods are provided, which methods relate to the induction of expression of calreticulin on phagocytic cells. Specifically, the methods relate to macrophage-mediated programmed cell removal (PrCR), the methods comprising increasing PrCR by contacting a phagocytic cell with a toll-like receptor (TLR) agonist; or down-regulating PrCR by contacting a phagocytic cell with an inhibitor of Bruton's tyrosine kinase (BTK). In some embodiments, an activator of TLR signaling or a BTK agonist is provided in combination with CD4 7 blockade.

Abstract: Methods, kits, and compositions are provided herein that can be used to treat CD20+ cancer using an anti-CD47 agent such as an antibody. The anti-CD47 agent can be used alone or in combination with one or more additional agent such as an anti-CD20 antibody.

Abstract: The invention relates to a method of attaching a gasket (4) to a bipolar plate (12). The method comprises the steps of applying and aligning a first gasket foil (4a) to a second gasket foil (4b) having connection recesses (8), connecting the first gasket foil (4a) to the second gasket foil (4b), so that the gasket (4) is formed, placing the gasket (4) on the bipolar plate (12) so that the second gasket film (4b) with the bonding recesses (8) abuts the bipolar plate (12) and performing an embossing step in which an embossing force is applied with an embossing tool (20) in the region of the connecting recesses (8) so that an embossed adhesive point (24) is formed and the first gasket foil (4a) is bonded to the bipolar plate (12) via an adhesive means (16) arranged in the connecting recess (8) on the first gasket foil (4a).

Abstract: A method of producing a silicon carbide (SiC) device includes: forming a stripe-shaped trench gate structure that extends from a first surface of a SiC body into the SiC body, the gate structure having a gate length along a lateral first direction, a bottom surface and a first gate sidewall of the gate structure being connected via a first bottom edge of the gate structure; forming at least one source region of a first conductivity type; and forming a shielding region of a second conductivity type in contact with the first bottom edge of the gate structure across at least 20% of the gate length. Forming the shielding region includes: forming a deep shielding portion; and forming a top shielding portion between the first surface and the deep shielding portion, the top shielding portion being in contact with the first bottom edge.

Abstract: A computer-implemented method for generating a 2D or 3D object, including training an autoencoder on a first set of training data to identify a first set of latent variables and generate a first set of output data; training an hourglass predictor on a second set of training data, where the hourglass predictor encoder converts a set of related but different training input data to a second set of latent variables, which decode into a second set of output data of the same type as the first set of output data; and using the hourglass predictor to predict a 2D or 3D object of the same type as the first set of output data based on a 2D or 3D object of the same type as the second set of input data.

Abstract: An apparatus and method of using the same for simulating surfing skateboarding, snowboarding or the like. The apparatus comprises a platform capable of supporting a user such as a continuous elastic surface such as trampoline or similar. A support is coupled to the platform for holding the platform. The apparatus further comprises a bearing or similar assembly coupled to the support for allowing the platform to rotate about an axis which is displaced a distance from the user while standing atop the platform during simulation thus simulating bottom and top turns. The apparatus further comprises a stand coupled to the bearing for securely supporting the bearing and tilting the axis of rotation.

Abstract: An oxygen evolution reaction catalyst includes a solid solution of at least one valve metal oxide and at least one noble metal oxide, wherein the valve metal oxide is selected from oxides of titanium, oxides of niobium, oxides of tungsten and oxides of tantalum, the noble metal oxide is selected from oxides of iridium, oxides of ruthenium and/or mixtures and/or alloys thereof, the BET specific surface area of the solid solution is greater than 10 m2/g, and the oxygen evolution reaction catalyst exhibits a weight loss of less than 2% by weight upon exposure of the oxygen evolution reaction catalyst to a 3.3 vol % hydrogen stream in argon at a temperature of 80° C. for 12 hours.

Abstract: A semiconductor device includes a semiconductor body comprising a first surface and an edge surface, a contact electrode formed on the first surface and comprising an outer edge side, and a passivation layer section conformally covering the outer edge side of the contact electrode. The passivation layer section is a multi-layer stack comprising a first layer, a second layer, and a third layer. Each of the first, second and third layers include outer edge sides facing the edge surface and opposite facing inner edge sides. The outer edge side of the contact electrode is disposed laterally between the inner edge sides and the outer edge sides of each layer.

Abstract: Methods are provided for treating a subject with an anti-CD47 agent.

Abstract: Example posture analysis systems and methods are described. In one implementation, a computing system identifies a deviation of a user's posture from a predetermined posture based on visual data associated with the user. The user is informed of the deviation via a graphical image displayed on a display device. The user is then provided with instructions for correcting the deviation via the graphical image displayed on the display device.

Abstract: A substance processing system includes a pressurizer configured to pressurize air and a processing chamber configured to process a substance. The system also includes a heat exchanger coupled between the pressurizer and the processing chamber. A nozzle is coupled to the processing chamber such that output from the nozzle comprises a substantially even pressure distribution.