Patents by Inventor Jens Ruhe

Jens Ruhe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROTEIN BINDERS FOR IRHOM2
    Publication number: 20220204610
    Abstract: The present invention relates to a protein binder that binds to human iRhom2, and inhibits and/or reduces TACE/ADAM17 activity when bound to human iRhom2.
    Type: Application
    Filed: April 9, 2020
    Publication date: June 30, 2022
    Inventors: Matthias Schneider, Kerstin Selle, Jens Ruhe, Gisela Weskamp, Carl Blobel
  • AXL ANTIBODIES
    Publication number: 20150152193
    Abstract: The present invention refers to antibodies, particularly to monoclonal antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity.
    Type: Application
    Filed: December 8, 2014
    Publication date: June 4, 2015
    Applicant: U3 PHARMA GMBH
    Inventors: Thore HETTMANN, Jens NIEWOEHNER, Jens RUHE, Peter WIRTZ, Kerstin SELLE, Esther ZWICK-WALLASCH, Mike ROTHE
  • HUMANIZED AXL ANTIBODIES
    Publication number: 20150037323
    Abstract: The present invention refers to monoclonal humanized antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity.
    Type: Application
    Filed: July 15, 2014
    Publication date: February 5, 2015
    Applicant: U3 PHARMA GMBH
    Inventors: Peter WIRTZ, Jens RUHE, Takeshi TAKIZAWA, Tomoko TAKAYAMA
  • AXL antibodies
    Patent number: 8933202
    Abstract: The present invention refers to antibodies, particularly to monoclonal antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity.
    Type: Grant
    Filed: November 12, 2008
    Date of Patent: January 13, 2015
    Assignee: U3 Pharma GmbH
    Inventors: Thore Hettmann, Jens Niewöhner, Jens Ruhe, Peter Wirtz, Kerstin Selle, Esther Zwick-Wallasch, Mike Rothe
  • Humanized AXL antibodies
    Patent number: 8841424
    Abstract: The present invention refers to monoclonal humanized antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity.
    Type: Grant
    Filed: May 11, 2010
    Date of Patent: September 23, 2014
    Assignee: U3 Pharma GmbH
    Inventors: Peter Wirtz, Jens Ruhe, Takeshi Takizawa, Tomoko Takayama
  • HUMANIZED AXL ANTIBODIES
    Publication number: 20120117670
    Abstract: The present invention refers to monoclonal humanized antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity.
    Type: Application
    Filed: May 11, 2010
    Publication date: May 10, 2012
    Applicant: U3 PHARMA GMBH
    Inventors: Peter Wirtz, Jens Ruhe, Takeshi Takilzawa, Tomoko Takayama
  • CANCER-RELATED PROTEIN KINASES
    Publication number: 20110008347
    Abstract: The present invention relates to mutant kinase polypeptides and kinase variants selected from the group consisting of AATYK (AATK), ABL1, ACK1, ALK, ARG, AXL, BMX, BRK, BTK, CCK4, CSFR1, CSK, DDR1, DDR2, EGFR, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FAK, FER, FES, FGFR1, FGFR2, FGFR4, FLT3, FRK, FYN, HER2, HER3, HER4, IGF1R, INSR, ITK, JAK1, JAK2, JAK3, LCK, LMTK2 (AATYK2/BREK), LYN, MATK, MER, MET, NTRK1, NTRK2, NTRK3, PDGRFA, PDGFRB, PTK-9, PYK2, RET, RON, ROR1, ROR2, ROS, RYK, STYK, SYK, TEC, TEK, TIE, TNK1, TXK, TYK2, TYRO3, VEGFR1, VEGFR2, VEGFR3, YES1, and ZAP70, nucleotide sequences encoding the mutant kinase polypeptides and kinase variants, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions, including the screening for and identification of novel protein kinase modulators.
    Type: Application
    Filed: December 3, 2007
    Publication date: January 13, 2011
    Inventors: Axel Ullrich, Jens Ruhe, Stefan Hart, Sylvia Street, Chee Hong Wong, Boon Tin Chua, Kiat Han Ho
  • AXL ANTIBODIES
    Publication number: 20100330095
    Abstract: The present invention refers to antibodies, particularly to monoclonal antibodies, which bind to the extracellular domain of the AXL receptor tyrosine kinase and which at least partially inhibit AXL activity.
    Type: Application
    Filed: November 12, 2008
    Publication date: December 30, 2010
    Applicant: U3 PHARMA GMBH
    Inventors: Thore Hettmann, Jens Niewoehner, Jens Ruhe, Peter Wirtz, Kerstin Selle, Esther Zwick-Wallasch, Mike Rothe