Abstract: The invention refers to the use of androgen receptor antagonists for the treatment and/or prevention of fibroids, also known as uterine leiomyoma, leiomyomata. Particularly, the invention refers to the use of an androgen receptor antagonist being any one of the compounds according to the following list: cyproterone acetate, oxendolone, chlormadinone acetate, spironolactone, osaterone acetate, dienogest, flutamide, hydroxyflutamide, nilutamide, bicalutamide, RU 58841, LGD-2226, MDV3100, BMS-641988, BMS-779333, or 4-(3-{[6-(2-hydroxy-2-methylpropoxy)pyridin-3-yl]methyl}-4,4-dimethyl-5-oxo-2-thioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile (thioxoimidazolidine derivative) for the treatment of fibroids.

Abstract: An apparatus for removing a surface layer from food products includes a product feed which feeds a product to be processed along a product conveying direction to a removal tool. The product is pressed with a component perpendicular to the product conveying direction toward an operative surface of the removal tool. The relative position between the product feed and the removal tool is adjustable by means of an adjustment apparatus, with a control unit associated with the adjustment apparatus designed to adjust the position of the removal tool relative to the product feed in dependence on the contour of the product.

Abstract: The invention discloses a styling copolymer, a styling composition of said copolymer a process for making it and its use for hair styling purposes. Said copolymer comprises colloidal silica and a copolymerized monomeric portion of at least one water-soluble monoolefinic monomer A and at least one monoolefinic silane monomer B with the weight portion of monomer B being less than 1% of the total weight of the monomeric portion.

Abstract: A press has a frame including guides extending in a predetermined direction and a pair of tool-halves mounted on the frame and are movable on the guides in the direction toward and away from each other. Two knee-lever linkages symmetrically spacedly flanking each tool half with respect to a center plane substantially parallel to the direction, each coupled to the respective tool half and to the frame, and operable to shift the tool halves in the direction. Respective reversible, rotary drives each carry an eccentric output connected to respective drive links extending to the linkages. A controller connected to the drives rotates the eccentrics oppositely in respective first senses to press the one half in the direction against the other half and thereafter to pull the one half in the direction away from the other half with the two linkages never extending into a central region of the machine.

Abstract: The invention relates to proteins, notably SAP-2 and SAP-3, having an antibiotic action. The invention also relates to a method for purifying certain antimicrobial proteins, as well as to a use of said antimicrobial proteins for antibiotic therapy or to a use of cells which were transfected with a DNA which codes for the proteins provided for in the invention.

Abstract: A press has a frame including guides extending in a predetermined direction and a pair of tool-halves mounted on the frame and are movable on the guides in the direction toward and away from each other. Two knee-lever linkages symmetrically spacedly flanking each tool half with respect to a center plane substantially parallel to the direction, each coupled to the respective tool half and to the frame, and operable to shift the tool halves in the direction. Respective reversible, rotary drives each carry an eccentric output connected to respective drive links extending to the linkages. A controller connected to the drives rotates the eccentrics oppositely in respective first senses to press the one half in the direction against the other half and thereafter to pull the one half in the direction away from the other half with the two linkages never extending into a central region of the machine.

Abstract: A method for testing the hormonal effect, especially the androgenic or antiandrogenic effect, of substances is described, in which (a) cells which are transfected with two vectors, one of these vectors containing DNA which codes for a nuclear receptor protein or a fragment thereof, whereas the other vector contains DNA which codes for a co-modulator or a fragment thereof, are exposed to the substance; and (b) the transcription activity which the nuclear receptor or its fragment induces in the presence of the co-modulator or its fragment and/or the effect of the substance on the interaction between the receptor or its fragment and the co-modulator or its fragment is measured by the protein-protein interaction or the protein-protein-DNA interaction. In addition, a method for determining defects in the co-modulation mechanism and means suitable for performing this method are provided.

Abstract: Novel substituted steroid compounds are disclosed which are more effective than known radical-trapping agents in methods of prophylaxis and therapy of radical-mediated cell damage and of treatment of diseases due to radical-mediated cell damage. The novel substituted steroid compounds can be made from steroids having an estrane, androstane, pregnane or cholestane basic skeleton and have a radical-attracting aromatic substituent of the general formula --(CH.sub.2).sub.n X, or .dbd.CH--(CH.sub.2).sub.m X at the 17 or 6 position of the steroid nucleus, wherein X=Y, OY, SY, SeY or NHY; n=0 to 5; m=n-1 and Y is a phenyl group having five substituents A, B, C, D and E, wherein A to E is independently H, alkyl, Oalkyl, Oacyl, OH, or one of the substituents B, C or D is NR.sub.2 wherein R=alkyl and each of the other substituents is hydrogen. Pharmaceutical compositions containing the novel substituted steroid compounds and methods of making them are also part of the invention.

Abstract: Disclosed are estrane derivatives having a radical-attracting aromatic substituent of the general formula --(CH.sub.2).sub.n X attached to the 17-position of the steroid nucleus, wherein X and n are as defined by the specification. The compounds are useful as antitumor agents and in the treatment of cardiac and circulatory disorders.

Abstract: Novel androgens having one or more substituents providing radical trapping properties are disclosed as useful in methods of treating androgen deficiency in man, benign prostate hypotropy and carcinoma of the prostate, osteoporosis, vascular disease-induced or ischemically-induced cerebral edemas, subarachnoid hemorrhages, ischemic shock, cerebral insult, Parkinson's disease and Alzheimer's disease. The androgen compound used for treating androgen deficiency in man has a steroid ring with an .alpha.-tocopherol group or a trolox group substituent.