Abstract: A method for treatment planning for a radiation therapy system includes setting a number of objectives reflecting clinical criteria are set for the regions of interest and generating radiation dose profiles to be delivered to these regions of interest. A convex optimization function for optimizing the delivered radiation based on the objectives is provided and dose profiles for specific treatment configurations including beam shape settings for the radiation dose profiles are calculated using the convex optimization function. Treatment plans including determining the radiation dose profiles to be delivered during treatment based on the treatment configurations are created and an optimal treatment plan that satisfies the clinical criteria is selected.

Abstract: Methods for dose or treatment planning for a radiotherapy system including a radiotherapy unit are provided. A spatial dose delivered can be changed by adjusting beam shape settings, and the delivered radiation is determined using an optimization problem that steers the delivered radiation according to objectives reflecting criteria for regions of interest including at least one of: targets to be treated during treatment of the patient, organs at risk and/or healthy tissue. The method includes determining an inner set of voxels and providing a first frame description for the inner set of voxels, where the first frame description reflects criteria for the inner set of voxels. Determining an outer set of voxels encompassing the target volume and the inner set of voxels and a frame description for the outer set of voxels is provided where each reflecting criteria for the outer set of voxels. The frame descriptions are then used in the optimization problem that steers the delivered radiation.

Abstract: A method of calibrating a positioning system in a radiation therapy system which includes a radiation therapy unit having a fixed radiation focus, includes irradiating a calibration tool having at least one reference object, capturing at least one two-dimensional image including cross-sectional representations of reference objects of the calibration tool and determining image coordinates of the representation of each reference object. Based on the reference objects' image coordinates, positions of the reference objects in the stereotactic coordinate system relative to an origin of the calibration tool and the position of the origin of the calibration tool relative to the imaging unit, a position difference between the position of the calibration tool in the stereotactic coordinate system and a position of the calibration tool in an imaging system coordinate system including a translational and rotational position difference is calculated.

Abstract: The present invention relates to the field of radiation therapy and methods, software and systems for image registration. According to the present invention, methods for image registration of images of a patient comprising are provided. The method may include receiving a set of image data from the patient; selecting one or more tracking regions in the set of image data, each tracking region including a tracking point or set of tracking points; receiving sets of image data captured at different times from the patient; identifying corresponding tracking regions in the sets of image data captured at different times; estimating a displacement field describing displacement vectors for a number of points in the sets of image data including the tracking regions, each displacement vector specifying a position of a region in reference to a previous position.

Abstract: In the field of radiotherapy, methods for dose or treatment planning for a radiotherapy system are disclosed, wherein a spatial dose delivered can be adjusted and delivered radiation is determined using an optimization problem that steers the delivered radiation according to a frame description reflecting criteria for regions of interest that include at least one of targets to be treated during treatment of the patient, organs at risk and/or healthy tissue. The method includes estimating a voxel set receiving a higher dose than a predetermined threshold dose level, which voxel set includes voxels from at least one target volume. Further, a low dose voxel set is determined and a frame description for the voxels in the low dose voxel set is provided where voxels receiving a dose exceeding a predetermined threshold value is penalized such that the dose delivered to the low dose voxel set is suppressed. The frame description is then used in the optimization problem that steers the delivered radiation.

Abstract: A method for treatment planning for a radiation therapy system includes setting a number of objectives reflecting clinical criteria are set for the regions of interest and generating radiation dose profiles to be delivered to these regions of interest. A convex optimization function for optimizing the delivered radiation based on the objectives is provided and dose profiles for specific treatment configurations including beam shape settings for the radiation dose profiles are calculated using the convex optimization function. Treatment plans including determining the radiation dose profiles to be delivered during treatment based on the treatment configurations are created and an optimal treatment plan that satisfies the clinical criteria is selected.

Abstract: The present invention relates to the field of radiation therapy. In particular, the present invention relates to methods for treatment planning for a radiation therapy system. The method includes setting a number of objectives reflecting clinical criteria are set for the regions of interest and generating radiation dose profiles to be delivered to these regions of interest. A convex optimization function for optimizing the delivered radiation based on the objectives is provided and dose profiles for specific treatment configurations including beam shape settings for the radiation dose profiles are calculated using the convex optimization function. Treatment plans including determining the radiation dose profiles to be delivered during treatment based on the treatment configurations are created and an optimal treatment plan that satisfies the clinical criteria is selected.

Abstract: In the field of radiotherapy, methods for dose or treatment planning for a radiotherapy system including a radiotherapy unit are described. A spatial dose delivered can be changed by adjusting beam shape settings, wherein delivered radiation is determined using an optimization problem that steers the delivered radiation according to objectives reflecting criteria for regions of interest including at least one of: targets to be treated during treatment of the patient, organs at risk and/or healthy tissue. The method includes determining an inner set of voxels and providing a first frame description for the inner set of voxels, where the first frame description reflects criteria for the inner set of voxels. Determining an outer set of voxels encompassing the target volume and the inner set of voxels and a frame description for the outer set of voxels is provided where each reflecting criteria for the outer set of voxels.

Abstract: In the field of radiotherapy, methods for dose or treatment planning for a radiotherapy system are disclosed, wherein a spatial dose delivered can be adjusted and delivered radiation is determined using an optimization problem that steers the delivered radiation according to a frame description reflecting criteria for regions of interest that include at least one of targets to be treated during treatment of the patient, organs at risk and/or healthy tissue. The method includes estimating a voxel set receiving a higher dose than a predetermined threshold dose level, which voxel set includes voxels from at least one target volume. Further, a low dose voxel set is determined and a frame description for the voxels in the low dose voxel set is provided where voxels receiving a dose exceeding a predetermined threshold value is penalized such that the dose delivered to the low dose voxel set is suppressed. The frame description is then used in the optimization problem that steers the delivered radiation.

Abstract: The present invention relates to the field of radiation therapy. In particular, the present invention relates to methods for treatment planning for a radiation therapy system. The method includes setting a number of objectives reflecting clinical criteria are set for the regions of interest and generating radiation dose profiles to be delivered to these regions of interest. A convex optimization function for optimizing the delivered radiation based on the objectives is provided and dose profiles for specific treatment configurations including beam shape settings for the radiation dose profiles are calculated using the convex optimization function. Treatment plans including determining the radiation dose profiles to be delivered during treatment based on the treatment configurations are created and an optimal treatment plan that satisfies the clinical criteria is selected.

Abstract: A method of calibrating a positioning system in a radiation therapy system is disclosed, including a radiation therapy unit having a fixed radiation focus. The method includes the steps of irradiating a calibration tool including at least one reference object, capturing at least one two-dimensional image including cross-sectional representations of reference objects of the calibration tool and determining image coordinates of the representation of each reference object. Based on the reference objects image coordinates, positions of the reference objects in the stereotactic coordinate system relative to an origin of the calibration tool and the position of the origin of the calibration tool relative to the imaging unit, a position difference between the position of the calibration tool in the stereotactic coordinate system and a position of the calibration tool in an imaging system coordinate system including a translational and rotational position difference is calculated.