Abstract: The invention relates to a mutant polypeptide having creatine amidinohydrolase activity, where the polypeptide both retains thermostable activity in the presence of reagents that modify thiol groups. The invention further relates to methods for producing the mutant polypeptide; and to a sensor comprising the mutant polypeptide for use in the measurement of creatinine in samples of physiological fluids. Additionally, the invention teaches how to use the mutant polypeptide to enhance the life-time of a creatinine sensor, and a method for producing the sensor.

Abstract: The invention relates to a mutant polypeptide having creatine amidinohydrolase activity, where the polypeptide both retains thermostable activity in the presence of reagents that modify thiol groups. The invention further relates to methods for producing the mutant polypeptide; and to a sensor comprising the mutant polypeptide for use in the measurement of creatinine in samples of physiological fluids. Additionally, the invention teaches how to use the mutant polypeptide to enhance the life-time of a creatinine sensor, and a method for producing the sensor.

Abstract: The invention concerns a semiconductor based light source comprising a back part, a front side and at least one semiconductor chip having an emitting surface, at least one reflective optical element being arranged below said at least one semiconductor chip, a material with low refractive index being disposed on a side of said reflective optical element facing said front side, wherein said semiconductor based light source comprises on said front side a compound material with high refractive index having at least one diffractive optical element embedded therein, such as to direct light incident on said diffractive optical element towards preferred directions.

Abstract: A method is provided for stabilizing a creatinine sensor comprising creatininase as a bioactive molecule. The creatininase is stabilised by exposing it to a sufficient amount of a divalent manganese ion. This result may be obtained by exposing the sensor to a solution comprising the divalent manganese ion or by introducing a composition within the sensor providing sustained release of the divalent manganese ion.

Abstract: A method and a system for determining the position of a radiation emitter, which radiation emitter may be an actively radiation emitting stylus, pen, pointer, or the like or may be a passive, radiation scattering/reflecting/diffusing element, such as a pen, pointer, or a finger of an operator. The radiation from the emitter is reflected from that position toward the detector by a reflecting element providing multiple intensity spots on the detector providing sufficient information for determining the position. From the output of the detector, the position of the radiation emitter is determined.