Patents by Inventor Jens Tiefenbach

Jens Tiefenbach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Uses for idebenone and related benzoquinones in metabolic disorders and other PPAR ?/? related diseases and conditions
    Patent number: 9770421
    Abstract: The present invention relates to the use of a 1,4-benzoquinone derived compound for the treatment of a disease or condition that is associated with peroxisome proliferator activated receptor (PPAR) activity in a mammal.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: September 26, 2017
    Assignee: INDANIO BIOSCIENCE INC.
    Inventors: Henry Krause, Jens Tiefenbach
  • USES FOR IDEBENONE AND RELATED BENZOQUINONES IN METABOLIC DISORDERS AND OTHER PPAR ALPHA/GAMMA RELATED DISEASES AND CONDITIONS
    Publication number: 20160022607
    Abstract: The present invention relates to the use of a 1,4-benzoquinone derived compound for the treatment of a disease or condition that is associated with peroxisome proliferator activated receptor (PPAR) activity in a mammal.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 28, 2016
    Inventors: Henry KRAUSE, Jens TIEFENBACH
  • Methods and compositions for the detection and isolation of ligands
    Patent number: 8236937
    Abstract: A method for the detection and isolation of ligands, preferably nuclear receptor ligands, bound to their cognate receptors in live animals, is described. A novel composition comprising 1) a chimeric transcription factor containing a DNA-binding domain, preferably from a non-vertebrate transcription factor, fused to the ligand-binding domain (LBD) of a nuclear receptor, 2) a reporter system, driven by a promoter that contains binding sites for the chosen DNA-binding domain, 3) multiple affinity tags fused to the LBD fusion proteins to facilitate efficient purification, along with specifically associated molecules and 4) sequences required for simultaneous genomic integration of all three components above are described. To make use of the system, expression of the chimeric LBD protein is broadly induced.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: August 7, 2012
    Assignee: InDanio Bioscience Inc.
    Inventors: Henry M. Krause, Jens Tiefenbach
  • Methods and Compositions for the Detection and Isolation of Ligands
    Publication number: 20080307534
    Abstract: A method for the detection and isolation of ligands, preferably nuclear receptor ligands, bound to their cognate receptors in live animals, is described. A novel composition comprising 1) a chimeric transcription factor containing a DNA-binding domain, preferably from a non-vertebrate transcription factor, fused to the ligand-binding domain (LBD) of a nuclear receptor, 2) a reporter system, driven by a promoter that contains binding sites for the chosen DNA-binding domain, 3) multiple affinity tags fused to the LBD fusion proteins to facilitate efficient purification, along with specifically associated molecules and 4) sequences required for simultaneous genomic integration of all three components above are described. To make use of the system, expression of the chimeric LBD protein is broadly induced.
    Type: Application
    Filed: December 22, 2006
    Publication date: December 11, 2008
    Inventors: Henry M. Krause, Jens Tiefenbach