Patents by Inventor Jens-Ulrich Buelow

Jens-Ulrich Buelow has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HUMAN POLYCLONAL ANTIBODIES FROM GENETICALLY ENGINEERED ANIMALS
    Publication number: 20150307595
    Abstract: Substantially human antisera are provided by genetically modifying a domestic animal generally weighing at least about 1 kg. The domestic animal is genetically modified by generating inactive heavy and light chain immunoglobulin loci and integrating at least functional portions of the human heavy and light chain immunoglobulin loci, whereby the human loci generate an immune response. The antisera find use in the treatment of diseases, immunocompromised patients and in case of transplantation.
    Type: Application
    Filed: July 2, 2015
    Publication date: October 29, 2015
    Inventor: Jens-Ulrich Buelow
  • Human Polyclonal Antibodies from Genetically Engineered Animals
    Publication number: 20080299112
    Abstract: Substantially human antisera are provided by genetically modifying a domestic animal generally weighing at least about 1 kg. The domestic animal is genetically modified by generating inactive heavy and light chain immunoglobulin loci and integrating at least functional portions of the human heavy and light chain immunoglobulin loci, whereby the human loci generate an immune response. The antisera find use in the treatment of diseases, immunocompromised patients and in case of transplantation.
    Type: Application
    Filed: August 8, 2008
    Publication date: December 4, 2008
    Inventor: Jens-Ulrich Buelow
  • Production of humanized antibodies in transgenic animals
    Publication number: 20070092505
    Abstract: This invention relates to humanized antibodies and antibody preparations produced from transgenic non-human animals. The non-human animals are genetically engineered to contain one or more humanized immunoglobulin loci which are capable of undergoing gene rearrangement and gene conversion in the transgenic non-human animals to produce diversified humanized immunoglobulins. The present invention further relates to novel sequences, recombination vectors and transgenic vectors useful for making these transgenic animals. The humanized antibodies of the present invention have minimal immunogenicity to humans and are appropriate for use in the therapeutic treatment of human subjects.
    Type: Application
    Filed: October 20, 2006
    Publication date: April 26, 2007
    Inventors: Roland Buelow, Josef Platzer, Wim Schooten, Jens-Ulrich Buelow
  • Production of humanized antibodies in transgenic animals
    Patent number: 7129084
    Abstract: This invention relates to humanized antibodies and antibody preparations produced from transgenic non-human animals. The non-human animals are genetically engineered to contain one or more humanized immunoglobulin loci which are capable of undergoing gene rearrangement and gene conversion in the transgenic non-human animals to produce diversified humanized immunoglobulins. The present invention further relates to novel sequences, recombination vectors and transgenic vectors useful for making these transgenic animals. The humanized antibodies of the present invention have minimal immunogenicity to humans and are appropriate for use in the therapeutic treatment of human subjects.
    Type: Grant
    Filed: August 3, 2001
    Date of Patent: October 31, 2006
    Assignee: Therapeutic Human Polyclonals, Inc.
    Inventors: Roland Buelow, Josef Platzer, Wim van Schooten, Jens-Ulrich Buelow
  • Production of humanized antibodies in transgenic animals
    Publication number: 20030017534
    Abstract: This invention relates to humanized antibodies and antibody preparations produced from transgenic non-human animals. The non-human animals are genetically engineered to contain one or more humanized immunoglobulin loci which are capable of undergoing gene rearrangement and gene conversion in the transgenic non-human animals to produce diversified humanized immunoglobulins. The present invention further relates to novel sequences, recombination vectors and transgenic vectors useful for making these transgenic animals. The humanized antibodies of the present invention have minimal immunogenicity to humans and are appropriate for use in the therapeutic treatment of human subjects.
    Type: Application
    Filed: August 3, 2001
    Publication date: January 23, 2003
    Inventors: Roland Buelow, Josef Platzer, Wim van Schooten, Jens-Ulrich Buelow
  • Human polyclonal antibodies from genetically engineered animals
    Publication number: 20020178456
    Abstract: Substantially human antisera are provided by genetically modifying a domestic animal generally weighing at least about 1 kg. The domestic animal is genetically modified by generating inactive heavy and light chain immunoglobulin loci and integrating at least functional portions of the human heavy and light chain immunoglobulin loci, whereby the human loci generate an immune response. The antisera find use in the treatment of diseases, immunocompromised patients and in case of transplantation.
    Type: Application
    Filed: June 26, 2002
    Publication date: November 28, 2002
    Inventor: Jens-Ulrich Buelow