Abstract: Devices and methods for processing a workpiece along a predetermined processing line are provided. The device includes: a pulsed, polychromatic laser beam generator; an optical arrangement; and a moving device. The laser beam generator generates a laser beam along a beam direction. The optical arrangement generates a focal line along the beam direction. The optical arrangement has a chromatic aberration for wavelength-dependent focusing of the laser beam and a filter for wavelength-dependent filtering of the laser beam. The moving device generates relative movement between the laser beam and the workpiece along the predetermined processing line.

Abstract: The invention relates to humanized antibodies that bind to an epitope at the N-terminus of pyroglutamated amyloid beta (A? N3pE) peptide and to preventive and therapeutic treatment of diseases and conditions that are related to accumulation and deposition of amyloid peptides, such as amyloidosis, a group of disorders and abnormalities associated with pyroglutamated amyloid peptide, like Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy and other related aspects. More specifically, it pertains to the use of humanized monoclonal antibodies to bind pyroglutamated amyloid beta peptide in plasma, brain, and cerebrospinal fluid to prevent accumulation or to reverse deposition of A? N3pE within the brain and in various tissues in the periphery, and to alleviate amyloidosis. The present invention further pertains to diagnostic assays for the diagnosis of amyloidosis using the humanized antibodies of the invention.

Abstract: A component of glass or glass ceramic having predamages arranged along at least one predetermined dividing line is provided. The dividing line has a row of predamages lying one behind the other. The predamages pass continuously through the glass or the glass ceramic with at least 90% of the predamages being cylindrically symmetrical. The glass or the glass ceramic has a material compaction of at least 1% relative to an actual material density in a radius of 3 ?m about a longitudinal axis of respective pre-damaged points. The relative weight loss per pre-damaged point is less than 10% and the component has a thickness of at least 3.5 mm.

Abstract: An optical layered composite includes: a substrate having a front face, a back face, a thickness ds between the front face and the back face and a refractive index ns; and a coating applied to the front face. The coating comprises one or more coating layers. For at least one wavelength ?g in the range from 390 nm to 700 nm, the coating satisfies one of the following criterion: nc<ns; or nc>ns, and d c < k n c 2 - n s 2 · arctan ? n s 2 - 1 n c 2 - n s 2 ; nc is a mean refractive index of the coating layers, weighted by thickness; do is a total thickness of the coating; thicknesses are determined in a direction perpendicular to the front face; and k=?g/4?.

Abstract: The present disclosure provides a device and a method for laser-based separation of a transparent, brittle workpiece, comprising a laser that emits a laser beam having an intensity (IL) along an optical axis (P), and an optical device. The optical device has at least one one-piece double axicon. The double axicon has an entrance surface and the optical device has an exit surface. The entrance surface is such that in the double axicon, a ring beam is formed. The intensity (IL) in the double axicon is lower than the threshold intensity (IS) of the material of the double axicon. The exit surface is such that a line focus having a maximum intensity (Imax) and a length (LT) is generated in the direction of the laser beam behind the exit.

Abstract: The present invention relates to bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis and related conditions, and provides a bacterial glutaminyl cyclase (bacQC); an antibody which recognizes the bacQC, a method for identifying an inhibitor of the bacQC; a compound according to Formula (I); a pharmaceutical composition comprising a bacQC inhibitor compound; a bacQC inhibitor compound and/or a pharmaceutical composition for use in a method for treatment of the human or animal body, for use in a method for therapy or prophylaxis of a bacterial infection, and for use in a method for therapy and/or prophylaxis of an acute, chronic or recurrent periodontal disease.

Abstract: The invention relates to a ball joint (10) for a wiper system, comprising a ball shell (12), a ball head (14) within the ball shell (12), a hinged rod (16) into which the ball shell (12) is inserted, and a securing means (18), wherein the securing means (18) engages around the hinged rod (16), in order to reduce an opening (20) in the ball shell (12) to a blocking distance (d), such that the ball head (15) can be removed from the ball shell (12). The invention further relates to a method for assembling the ball joint (10).

Abstract: A ball joint (28) includes a socket assembly (60) that provides a locking feature designed to work in combination with the ball stud to retain a rotatable connection between the ball stud (30) and the ball socket. The socket assembly includes a socket housing (62) and an elastic retaining member (82) that cooperate to prevent ball stud disengagement under operating loads. The socket housing includes a sidewall (65) that has an extended length relative to some conventional socket housings, and the elastic member is disposed in a circumferential groove formed in an outer surface of the ball socket at a location corresponding to the extended length.

Abstract: A semiconductor device includes a base layer, a dielectric layer over the base layer, an opening extending through the dielectric layer and to a main surface of the base layer, the opening having a sloped sidewall, and an electrically conductive material over the sloped sidewall. An angle between the sloped sidewall and the main surface of the base layer is in a range between 5 degrees and 50 degrees. Corresponding methods of manufacturing the semiconductor device are also provided.

Abstract: Placement of a medical device within or in proximity to a substantially fluid filled compartment within a human body is aided by pulse-echo ultrasound and a time-stretching technique. In one embodiment, a small ultrasound transducer is placed near the tip of a catheter intended to be positioned within a ventricle of the brain to drain cerebrospinal fluid. The transducer is electrically pulsed so as to emit sound waves, and then used to receive returning echoes which contain information about structures in front of the transducer. These returning echoes are electronically amplified and processed in such a way that the information represented by the echoes is spread out over a much longer period than the actual acquisition time. This processed information may be presented to an operator visually, via audio feedback and/or via tactile feedback. Embodiments are disclosed where the information is displayed visually through variations in the color or brightness of a light source over time.

Abstract: Some embodiments include a system. The system comprises an input device, an output device, one or more processing modules, and one or more non-transitory memory storage modules storing computer instructions. The computer instructions are configured to run on the processing module(s) and perform the acts of: identifying at least one test web page; and analyzing a first test web page of the at least one test web page. The analyzing the first test web page of the at least one test web page comprises crawling the first test web page to detect a first adverse performance condition of the first test web page, and the first adverse performance condition can impact a first search rank assigned to the first test web page when present. Other embodiments of related systems and methods are also provided.

Abstract: A semiconductor device includes a base layer, a dielectric layer over the base layer, an opening extending through the dielectric layer and to a main surface of the base layer, the opening having a sloped sidewall, and an electrically conductive material over the sloped sidewall. An angle between the sloped sidewall and the main surface of the base layer is in a range between 5 degrees and 50 degrees. Corresponding methods of manufacturing the semiconductor device are also provided.

Abstract: The invention relates to humanized antibodies that bind to an epitope at the N-terminus of pyroglutamated amyloid beta (A? N3pE) peptide and to preventive and therapeutic treatment of diseases and conditions that are related to accumulation and deposition of amyloid peptides, such as amyloidosis, a group of disorders and abnormalities associated with pyroglutamated amyloid peptide, like Alzheimer's disease, Down's syndrome, cerebral amyloid angiopathy and other related aspects. More specifically, it pertains to the use of humanized monoclonal antibodies to bind pyroglutamated amyloid beta peptide in plasma, brain, and cerebrospinal fluid to prevent accumulation or to reverse deposition of A? N3pE within the brain and in various tissues in the periphery, and to alleviate amyloidosis. The present invention further pertains to diagnostic assays for the diagnosis of amyloidosis using the humanized antibodies of the invention.

Abstract: The invention relates to a highly sensitive method for the detection of pGlu-Abeta (pGlu-A?) peptides and the use of this method in the diagnosis of neurodegenerative diseases, such as Alzheimer's disease and Mild Cognitive Impairment. The invention further concerns a novel method for monitoring the effectiveness of a treatment of neurode-generative diseases by monitoring changes in the level of pGlu-A? peptides.

Abstract: A wind turbine blade having a surface mounted device attached thereto via at least a first attachment part, which is connected to a part of the device. The first attachment part comprises an outer attachment part providing a first bonding connection between the device and the surface of the blade, wherein the first bonding connection is an elastic bond, and an inner attachment part providing a second bonding connection between the device and the surface of the blade, wherein the second bonding connection has a structural bond. The structural bond prevents the surface mounted device from creeping and the elastic bond region relieves stresses on the bond line, such as peel stresses, whereby the surface mounted device is less likely to be ripped off the surface of the blade due to forces affecting the device or the blade.

Abstract: Diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.

Abstract: A system and method for providing real-time, image-guided high intensity focused ultrasound (HIFU) targeting and treatment of tissue. In one embodiment, the system includes an HIFU applicator and a user interface with a touchscreen display for three-dimensional visualization of the tissue. Image frames displayed on the user interface depict real-time images of the tissue, including an image parallel to a feature of the applicator and an image orthogonal to the parallel image. Reference lines may be sketched using the touchscreen and displayed on the image frames. In one embodiment, tissue boundaries are detected and marked on the image frames, either by the user or automatically by the system. In another embodiment, the user interface includes a footswitch for the user to interact with the system. In another embodiment, the system includes an ultrasound imaging component configured to undock from the system for use as a stand-alone ultrasound imaging device.

Abstract: Diagnostic assays for the diagnosis of amyloidosis, in particular Alzheimer's disease, and related aspects. In particular, monoclonal antibodies and an antibody assay are provided.

Abstract: A method for predicting, diagnosing and prognosticating a neurodegenerative disease, such as Alzheimer's disease (AD), Mild Cognitive Impairment (MCI) and neurodegeneration in Down's syndrome (NDS) using glutaminyl cyclase (QC) as a diagnostic/prognostic indicator. The use of antibodies binding to QC and kits for performing said diagnostic method are also provided.

Abstract: Some embodiments include a system. The system comprises an input device, an output device, one or more processing modules, and one or more non-transitory memory storage modules storing computer instructions. The computer instructions are configured to run on the processing module(s) and perform the acts of: identifying at least one test web page; and analyzing a first test web page of the at least one test web page. The analyzing the first test web page of the at least one test web page comprises crawling the first test web page to detect a first adverse performance condition of the first test web page, and the first adverse performance condition can impact a first search rank assigned to the first test web page when present. Other embodiments of related systems and methods are also provided.