Patents by Inventor Jens Uwe Riesle
Jens Uwe Riesle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9072819Abstract: The present invention relates in one aspect to the use of a matrix gel comprising chondrocytes or progenitor cells thereof in a density below that of natural cartilage as a cartilage repair implant wherein said cells exhibit increases production of extracellular matrix material.Type: GrantFiled: August 31, 2007Date of Patent: July 7, 2015Assignee: CELLCOTEC B.V.Inventors: Jeanine Anna Alphonse Hendriks, Jens Uwe Riesle
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Publication number: 20140329316Abstract: The invention relates to the field of medical science, in particular to technology directed at repairing defects in living, preferably human, tissue. The present invention provides a method for inducing differentiation of multipotent cells to a desired cell type, as well as a method for repairing a tissue defect in a human or animal patient using the concept of said method for inducing differentiation of multipotent cells. The invention further relates to a kit for carrying out the method for repairing a tissue defect.Type: ApplicationFiled: July 21, 2014Publication date: November 6, 2014Inventors: Jeanine Anna Alphonse HENDRIKS, Mark Ewart DE BRUIJN, Jens Uwe RIESLE
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Patent number: 8796019Abstract: The invention relates to the field of medical science, in particular to technology directed at repairing defects in living, preferably human, tissue. The present invention provides a method for inducing differentiation of multipotent cells to a desired cell type, as well as a method for repairing a tissue defect in a human or animal patient using the concept of said method for inducing differentiation of multipotent cells. The invention further relates to a kit for carrying out the method for repairing a tissue defect.Type: GrantFiled: August 29, 2011Date of Patent: August 5, 2014Assignee: CellCoTec B.V.Inventors: Jeanine Anna Alphonse Hendriks, Mark Ewart De Bruijn, Jens Uwe Riesle
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Publication number: 20140105938Abstract: An automated or semi-automated module-based cartilage cell processing device (20) for preparing a cell seeded carrier (27a) from a biological material, comprising at least a cartilage preparation module (21), a cell isolation module (22), a cell mixing module (29) and a carrier cell seeding module (29a). The invention further relates to the individual modules of the module-based cartilage cell processing device (20).Type: ApplicationFiled: March 22, 2012Publication date: April 17, 2014Applicant: CELLCOTEC B.V.Inventors: Jeanine Anna Alphonse Hendriks, Jens Uwe Riesle, Clayton Ellis Wilson, Mirella Ageeth Van Den Doel
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Publication number: 20120053558Abstract: The invention relates to the field of medical science, in particular to technology directed at repairing defects in living, preferably human, tissue. The present invention provides a method for inducing differentiation of multipotent cells to a desired cell type, as well as a method for repairing a tissue defect in a human or animal patient using the concept of said method for inducing differentiation of multipotent cells. The invention further relates to a kit for carrying out the method for repairing a tissue defect.Type: ApplicationFiled: August 29, 2011Publication date: March 1, 2012Applicant: CellCoTec B.V.Inventors: Jeanine Anna Alphonse Hendriks, Mark Ewart De Bruijn, Jens Uwe Riesle
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Patent number: 8048671Abstract: The invention relates to the field of medical science, in particular to technology directed at repairing defects in living, preferably human, tissue. The present invention provides a method for inducing differentiation of multipotent cells to a desired cell type, as well as a method for repairing a tissue defect in a human or animal patient using the concept of said method for inducing differentiation of multipotent cells. The invention further relates to a kit for carrying out the method for repairing a tissue defect.Type: GrantFiled: March 18, 2005Date of Patent: November 1, 2011Assignee: Cellcotec B.V.Inventors: Jeanine Anna Alphonse Hendriks, Mark Ewart De Bruijn, Jens Uwe Riesle
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Publication number: 20100047316Abstract: The present invention relates in one aspect to the use of a matrix gel comprising chondrocytes or progenitor cells thereof in a density below that of natural cartilage as a cartilage repair implant wherein said cells exhibit increases production of extracellular matrix material.Type: ApplicationFiled: August 31, 2007Publication date: February 25, 2010Inventors: Jeanine Anna Alphonse Hendriks, Jens Uwe Riesle
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Patent number: 6737073Abstract: A biodegradable, biocompatible porous matrix as a scaffold for tissue engineering cartilage is formed of a copolymer of a polyalkylene glycol and an aromatic polyester such as a polyethylene glycol/polybutylene terephtalate copolymer. A ceramic coating such as a calcium phosphate coating may be provided on the scaffold by soaking the scaffold in a solution containing calcium and phosphate ions. A composite scaffold which may be used as an implant is preferably a two-layer system may be formed having an outer surface of a layer of the porous matrix formed of the copolymer, and an outer surface of a layer of a ceramic material. The composite scaffold may be prepared by casting the copolymer on top of the ceramic material in a mould. Cells are preferably seeded on the scaffold prior to implanting, and the scaffold may contain bioactive agents that are released on degradation of the scaffold in vivo.Type: GrantFiled: September 5, 2001Date of Patent: May 18, 2004Assignee: IsoTis N.V.Inventors: Tahir Mahmood, Jens Uwe Riesle, Clemens Antoni van Blitterswijk
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Patent number: 6692761Abstract: A biodegradable, biocompatible porous matrix as a scaffold for tissue engineering cartilage is formed of a copolymer of a polyalkylene glycol and an aromatic polyester such as a polyethylene glycol/polybutylene terephtalate copolymer. A ceramic coating such as a calcium phosphate coating may be provided on the scaffold by soaking the scaffold in a solution containing calcium and phosphate ions. A composite scaffold which is preferably a two-layer system may be formed having an outer surface of a layer of the porous matrix formed of the copolymer, and an outer surface of a layer of a ceramic material. The composite scaffold may be prepared by casting the copolymer on top of the ceramic material in a mould. Cells are preferably seeded on the scaffold prior to implanting, and the scaffold may contain bioactive agents that are released on degradation of the scaffold in vivo.Type: GrantFiled: September 5, 2001Date of Patent: February 17, 2004Assignee: IsoTis N.V.Inventors: Tahir Mahmood, Jens Uwe Riesle, Clemens Antoni van Blitterswijk
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Patent number: 6656489Abstract: A biodegradable, biocompatible porous matrix as a scaffold for tissue engineering cartilage is formed of a copolymer of a polyalkylene glycol and an aromatic polyester such as a polyethylene glycol/polybutylene terephtalate copolymer. A ceramic coating such as a calcium phosphate coating may be provided on the scaffold by soaking the scaffold in a solution containing calcium and phosphate ions. A composite scaffold which is preferably a two-layer system may be formed having an outer surface of a layer of the porous matrix formed of the copolymer, and an outer surface of a layer of a ceramic material. The composite scaffold may be prepared by casting the copolymer on top of the ceramic material in a mould. Cells are preferably seeded on the scaffold prior to implanting, and the scaffold may contain bioactive agents that are released on degradation of the scaffold in vivo.Type: GrantFiled: February 4, 2000Date of Patent: December 2, 2003Assignee: IsoTis N.V.Inventors: Tahir Mahmood, Jens Uwe Riesle, Clemens Antoni van Blitterswijk
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Publication number: 20020072798Abstract: Novel scaffolds for tissue engineering muscle are provided that include copolymers of a polyalkylene glycol and an aromatic polyester in the form of a matrix. The scaffold can include autologous muscle cells and/or stem cells.Type: ApplicationFiled: September 19, 2001Publication date: June 13, 2002Inventors: Jens Uwe Riesle, Clemens Antoni van Blitterswijk, Maria Papadaki, Robert Langer
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Publication number: 20020009477Abstract: The invention relates to the use of a biodegradable, biocompatible porous matrix as a scaffold for tissue engineering cartilage, which matrix is formed of a copolymer of a polyalkylene glycol and an aromatic polyester.Type: ApplicationFiled: September 5, 2001Publication date: January 24, 2002Applicant: IsoTis N.V.Inventors: Tahir Mahmood, Jens Uwe Riesle, Clemens Antoni van Blitterswijk
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Publication number: 20020006428Abstract: The invention relates to the use of a biodegradable, biocompatible porous matrix as a scaffold for tissue engineering cartilage, which matrix is formed of a copolymer of a polyalkylene glycol and an aromatic polyester.Type: ApplicationFiled: September 5, 2001Publication date: January 17, 2002Applicant: IsoTis N.V.Inventors: Tahir Mahmood, Jens Uwe Riesle, Clemens Antoni van Blitterswijk