Abstract: The invention relates to a method for reducing the losses of valuable substances in mineral processing, wherein a mineral mixture, dry or suspended, has a grain fraction with a tailings portion and a superficial valuable material portion after a first separation stage, and the tailings portion quantitatively exceeds the valuable material portion, the mineral mixture being suspended, insofar as it is not already a suspension, for the agglomeration of grains of the grain fraction with the valuable material portion, and a substantially hydrophobic agent with a content of anionic or cationic amphiphilic molecules is added to the suspended mineral mixture in order to wet the surface of the valuable substance portion to form agglomeration bridges between the valuable material portions of the grains, wherein the mineral mixture is routed in a solution saturated with the valuable material portion and the tailings to a wet separation stage for classification into a fraction richer in valuable material and a fraction l