Abstract: An ingestible device (200), comprising: a housing (210, 220) comprising a stop geometry (228) at an exit hole (224); a tissue penetrating member (230) and an actuator that comprises: a pushing portion (260) configured for axial movement from a first to a second position, the pushing portion configured to move the tissue penetrating member from within the housing to a lodged position in tissue, and a holder portion (270) coupled with the pushing portion (260) for initial axial movement with the pushing portion. In the first position the holder portion releasably holds the tissue penetrating member (230) in axial retaining engagement. As the pushing portion (260) moves towards the second position, the tissue penetrating member (230) moves through the exit hole (224) until the holder portion (270) enters into engagement with the stop geometry (228). The pushing portion (260) moves further to release and advance the tissue penetrating member (230).

Abstract: A CD19-OR-CD20 chimeric antigen receptor (CAR) protein construct is provided. Also provided are nucleic acids encoding the CD19-OR-CD20 CAR; and methods of use, e.g. in the treatment of B cell malignancies. The CD19-OR-CD20 CAR of the invention is a bispecific CAR that can trigger T-cell activation upon detection of either CD19 or CD20 (or both). It is a single molecule that confers two-input recognition capability upon human T cells engineered to stably express this CAR.

Abstract: A device includes a memory configured to store a first token that indicates that a first entity has data authority of a first data object. The device also includes one or more processors configured to receive a data authority request from a second entity to transfer the data authority of the first data object to the second entity. The one or more processors are further configured to, based on a determination that a data authority transfer criterion is satisfied, generate a second token that indicates that the second entity has the data authority of the first data object. The one or more processors are further configured to generate a first reference that indicates that the second token is related and subsequent to the first token.

Abstract: An example hydraulic tool includes: a fluid reservoir; a pump; an electric motor; a cylinder; a piston; a first trigger button; a second trigger button; and a controller configured to perform operations comprising: receiving a first signal when the first trigger button is triggered, responsively, causing the electric motor to rotate in a first rotational direction, thereby: (i) causing the pump to provide fluid to the cylinder, and (ii) causing the piston to move in a first linear direction, thereafter, receiving a second signal when the second trigger button is triggered, and responsively to the second signal, causing the electric motor to rotate in a second rotational direction opposite the first rotational direction, thereby: (i) opening a fluid path from the cylinder to the fluid reservoir, and (ii) causing the piston to move in a second linear direction opposite the first linear direction.

Abstract: Wind turbine cable connector monitoring method and device for monitoring a connector (1) attached to cable (4). A temperature sensor (6) is provided for sensing a measured temperature at a position a known distance along the cable (4) from the connector (1). A controller (8,19) records the measured temperature from the temperature sensor (6) while the connector (4) is in use, and identifies a potential fault condition in the connector (4) based on the measured temperature and the position the known distance along the cable (4) from the connector (1).

Abstract: A network filter request arbiter is provided. An interface (e.g., user interface and/or programmatic interface, such as an application programming interface (API)), is for configuring and automatically implementing one or more filters in an internal and/or external network. The filters may be used to stop distributed denial of service (DDOS) attacks and/or prevent malicious network traffic from reaching a target network or target device(s) within the target network. Filters implemented in a target network may also be distributed to other (e.g., upstream) networks. The distributed filters may similarly be used to stop DDOS attacks and/or prevent malicious network traffic from being carried by the networks and from reaching a target network or target device(s) within the target network.

Abstract: An injection mold for the manufacture of an axisymmetric part of composite material comprising a mandrel supporting a fibrous preform and comprising an annular wall, and a plurality of counter-mold angular sectors assembled to the mandrel and intended to close the mold and to compact the fibrous preform wound on the mandrel. Each angular sector comprises an annular base intended to come into contact with the fibrous preform. The plurality of angular sectors includes a first series of angular sectors and a second series of angular sectors, first and second lateral edges of the first series of sectors each including a protruding lower portion, the first and the second lateral edges of the second series of sectors each including a recessed lower portion.

Abstract: A fibre cement plate includes a rectangular body having a top edge and a bottom edge arranged spaced apart and substantially parallel to each other, first and second lateral edges arranged spaced apart and substantially perpendicularly to the top and bottom edges and inwards and outwards facing surfaces. Further, the first and second lateral edges are disposed substantially parallel to each other and connect the top and bottom edges. Moreover, the bottom edge is provided with a longitudinal groove and the top edge is provided with an elongated projection adapted to be inserted inside an elongated groove of a bottom edge of an adjacent identical fibre cement plate. Also, the first lateral edge is provided with an elongated groove and the second lateral edge is provided with an elongated projection adapted for insertion inside an elongated groove of a first lateral edge of an adjacent identical fibre cement plate.

Abstract: Disclosed is a method for controlling an auto injector and an auto injector for administering a medicament from a cartridge having a first cartridge end and a second cartridge end and having a cartridge outlet at the first cartridge end, the cartridge comprising a cartridge compartment with a first cartridge subcompartment containing a first medicament component of the medicament and a second cartridge subcompartment containing a second medicament component of the medicament. The auto injector comprises: a housing; a cartridge receiver; a cartridge sensor; a drive module; an orientation sensor; and a processing unit.

Abstract: The present disclosure provides a method, performed in an accessory device, for communicating a leakage state of an ostomy appliance, wherein the accessory device comprises an interface configured to communicate with one or more devices of an ostomy system, the one or more devices comprising a monitor device, and/or the ostomy appliance configured to be placed on a skin surface of a user. The method comprises obtaining monitor data from the one or more devices, the monitor data being indicative of presence of fluid at a proximal side of a first adhesive layer of the ostomy appliance towards the skin surface; determining a leakage state at the proximal side of the first adhesive layer of the ostomy appliance based on the monitor data, and communicating the leakage state of the ostomy appliance via the interface.

Abstract: An ear-worn electronic device comprises a housing configured to be supported by, at, in or on an ear of a wearer. Electronic circuitry is disposed in the housing and comprises a processor. A power source and a receiver or a speaker are respectively disposed in or on the housing. A microphone array is disposed in or on the housing and operatively coupled to the electronic circuitry. The microphone array comprises a plurality of microphones. The processor is configured to operate a set of two or more of the microphones in a directional mode, detect degradation in performance of any microphone of the microphone set, and switch microphone operation from the directional mode to a safe mode using at least one non-degraded microphone of the microphone set in response to detecting the microphone performance degradation.

Abstract: A backpack includes a frame, a pack attached to the frame to define an interior space, and at least one divider positioned within the interior space to define at least one compartment within the interior space. The frame and the pack define a horizontal direction, a vertical direction, and a depth direction within the backpack. The compartment positions at least one equipment within the interior space such that a center of mass of the backpack is centered on a backpacker's back when the backpacker is wearing the backpack centered in the horizontal direction and the vertical direction within the interior space.

Abstract: A verification operating system (VOS) is an intermediary operating system that verifies data of a primary operating system before the primary operating system controls of the computing device. When the computing device is initialized, initial boot processes load the VOS instead of the primary operating system. The VOS performs verification processes on data storing the primary operating system to verify that the primary operating system has not been manipulated or corrupted before passing control of the computing device to the primary operating system. A VOS also may be used to verify an operating system used by a virtual machine (VM). The VOS verifies data storing a VM operating system to be used for requested VMs. If the VOS verifies that the VM OS data is accurate, the VOS provides the VM OS data to a hypervisor for use in a VM.

Abstract: Tin oxide films are used as spacers and hardmasks in semiconductor device manufacturing. In one method, tin oxide layer (e.g., spacer footing) needs to be selectively etched in a presence of an exposed silicon-containing layer, such as SiOC, SiON, SiONC, amorphous silicon, SiC, or SiN. In order to reduce damage to the silicon-containing layer the process involves passivating the silicon-containing layer towards a tin oxide etch chemistry, etching the tin oxide, and repeating passivation and etch in an alternating fashion. For example, passivation and etch can be each performed between 2-50 times. In one implementation, passivation is performed by treating the substrate with an oxygen-containing reactant, activated in a plasma, and the tin oxide etching is performed by a chlorine-based chemistry, such as using a mixture of Cl2 and BCl3.

Abstract: Techniques that enable the installation of a level sensor capable of continuously detecting a level of fluid in a vessel or tank and capable of being integrated in a larger control system. Advantageously, the sensor head of the level sensor can be installed on existing installations with an existing displacer or float and an existing member or rod. The techniques thus enable process plants to easily and affordably replace pneumatic level sensors with a more environmentally friendly option.

Abstract: Aspects of the present disclosure relates to genetically altered LysM receptors. In particular, the present disclosure relates to a hydrophobic patch into the LysM2 domain which can increase affinity and/or selectivity for LCOs and by replacement of regions in the LysM1 domain with the corresponding regions of the LysM1 domain from a donor LysM receptor that can alter the affinity and/or selectivity for the oligosaccharide particularly for LCOs and can alter the specificity between LCO when using regions from a high affinity and specificity LCO LysM receptor such as a legume NFR1 receptor. The present disclosure also relates to genetically altering LysM receptors in plants to include a hydrophobic patch or alter the hydrophobic patch and to genetically altering LysM receptors in plants by replacement of regions in the LysM2 domain.

Abstract: Examples of the present disclosure describe systems and methods for zero trust domain name system (DNS) (ZTDNS) based networking. A computing device implementing ZTDNS based networking blocks any outbound connections that are not included in a list of trusted IP addresses. The list of trusted IP addresses is updated in response to the computing device receiving from a trusted DNS server an IP address corresponding to a DNS request. In some examples, the ZTDNS based networking intercepts and evaluates outbound communications for applications that implement a custom application DNS client. In other examples, the ZTDNS based networking intercepts and evaluates outbound communications for virtual environments. The outbound communications for both the custom application DNS client and the virtual environments are proxied through a local DNS client of the computing device.

Abstract: An instrumented substrate may provide a metrology platform for monitoring extreme ultraviolet (EUV) radiation in an image plane of a EUV lithography tool. The instrumented substrate may include in-band dosage sensors. The in-band dosage sensors may generate dosage measurements corresponding to the illumination which is in-band. The instrumented substrate may also include out-of-band dosage sensors and in-band scattered dosage sensors. The instrumented substrate may be housed within a front opening unified pod (FOUP) of a system.

Abstract: Embodiments of the methods and compositions provided herein relate to chimeric antigen receptors (CARs) that specifically bind to B7H3. Some embodiments relate to cell-based immunotherapy targeting tumors, such as tumors comprising B7H3+ cells.

Abstract: The present disclosure relates to antisense oligonucleotides, which target SNCA mRNA (e.g., at an intron exon junction) in a cell, leading to reduced expression of SNCA protein. Reduction of SNCA protein expression is beneficial for the treatment of certain medical disorders, e.g., a neurological disorder.