Patents by Inventor Jenson Qi
Jenson Qi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7892826Abstract: Human cell clones with increased specific binding to urotensin II have been sub-cloned from SJRH30 (ATCC® Number: CRL-2061™). These cell clones have been used for functional analyses of the biological activity of an endogeneous urotensin II receptor, as well as for identifying compounds that regulate the biological activity of an Urotensin II receptor.Type: GrantFiled: August 9, 2006Date of Patent: February 22, 2011Assignee: Janssen Pharmaceutica N.V.Inventors: Lisa Minor, Jenson Qi, Yuanping Wang
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Publication number: 20070218026Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease EOS. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease EOS mRNA is expressed in platelets and leukocytes and more specifically eosinophils. Although this protease is abundantly expressed in ovary, retina and stomach, where it may perform important functions, its expression in platelets and certain cells of the immune system suggests that it may play roles in thrombosis and in the immune process.Type: ApplicationFiled: January 8, 2002Publication date: September 20, 2007Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Gordon
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Publication number: 20070087326Abstract: Administration of U-II to a cell having a functional urotensin II receptor caused an increase in the electrical impedance of the cell in a receptor specific and dose dependent manner. Thus, the present invention provides methods of measuring the biological activity of an U-II receptor by monitoring the electrical impedance of the cell, and the use of the methods to identify a cell having a functional U-II receptor, as well as to identify compounds that increase or decrease the biological activity of an U-II receptor.Type: ApplicationFiled: August 10, 2006Publication date: April 19, 2007Inventors: Lisa Minor, Jenson Qi, Yuanping Wang
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Publication number: 20070082368Abstract: Human cell clones with increased specific binding to urotensin II have been sub-cloned from SJRH30 (ATCC® Number: CRL-2061™). These cell clones have been used for functional analyses of the biological activity of an endogeneous urotensin II receptor, as well as for identifying compounds that regulate the biological activity of an Urotensin II receptor.Type: ApplicationFiled: August 9, 2006Publication date: April 12, 2007Inventors: Lisa Minor, Jenson Qi, Yuanping Wang
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Publication number: 20060063235Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease C-E mRNA is expressed in pancreas, placenta, prostate, small intestine, stomach, spleen, fibroblasts and epidermis, as well as in certain regions of the brain i.e., cerebellum, cerebral cortex, pituitary and hippocampus. Enzymatically active protease C-E, as produced using the methodologies described herein, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.Type: ApplicationFiled: November 12, 2004Publication date: March 23, 2006Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Grodon
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Patent number: 6887987Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease T. The deduced amino acid sequence encodes a prepro form of 290 amino acids, and its alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease T mRNA is expressed in stomach, testis, retina, fibroblasts, spinal cord, and several regions of the brain. Protease T mRNA is also found in leukocytes and in the Jurkat (ATCC TIB-152) T cell line. Thus, this protease is potentially involved in gastric, testicular, retinal, dematological, neurological/neurodegenerative and/or immunological disorders. The protease T gene maps to human chromosome 16p13.3 which is near the tryptase locus. Enzymatically active protease T, we have generated, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.Type: GrantFiled: January 7, 2002Date of Patent: May 3, 2005Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Grodon
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Patent number: 6861399Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease T. The deduced amino acid sequence encodes a prepro form of 290 amino acids, and its alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease T mRNA is expressed in stomach, testis, retina, fibroblasts, spinal cord, and several regions of the brain. Protease T mRNA is also found in leukocytes and in the Jurkat (ATCC TIB-152) T cell line. Thus, this protease is potentially involved in gastric, testicular, retinal, dematological, neurological/neurodegenerative and/or immunological disorders. The protease T gene maps to human chromosome 16p13.3 which is near the tryptase locus. Enzymatically active protease T, we have generated, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.Type: GrantFiled: January 7, 2002Date of Patent: March 1, 2005Assignee: Ortho-McNeil Pharmaceutical , Inc.Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Grodon
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Patent number: 6849421Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease C-E mRNA is expressed in pancreas, placenta, prostate, small intestine, stomach, spleen, fibroblasts and epidermis, as well as in certain regions of the brain i.e., cerebellum, cerebral cortex, pituitary and hippocampus. Enzymatically active protease C-E, as produced using the methodologies described herein, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.Type: GrantFiled: January 7, 2002Date of Patent: February 1, 2005Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Grodon
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Patent number: 6846920Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease EOS. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease EOS mRNA is expressed in platelets and leukocytes and more specifically eosinophils. Although this protease is abundantly expressed in ovary, retina and stomach, where it may perform important functions, its expression in platelets and certain cells of the immune system suggests that it may play roles in thrombosis and in the immune process. Enzymatically active protease EOS is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.Type: GrantFiled: January 8, 2002Date of Patent: January 25, 2005Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Gordon
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Publication number: 20050014242Abstract: We describe the DNA sequences encoding an expression vector system that will permit, through limited proteolysis, the activation of expressed zymogen precursor of (S1) serine proteases in a highly controlled and reproducible fashion. The processed expressed protein, once activated, is rendered in a form amenable to measuring the catalytic activity. This catalytic activity of the activated form, is often a more accurate representation of the mature S1 protease gene product relative to the unprocessed zymogen precursor. Thus, this series of zymogen activation constructs represents a significant system for the analysis and characterization of serine protease gene products.Type: ApplicationFiled: December 10, 2001Publication date: January 20, 2005Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Grodon
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Patent number: 6806059Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease EOS. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease EOS mRNA is expressed in platelets and leukocytes and more specifically eosinophils. Although this protease is abundantly expressed in ovary, retina and stomach, where it may perform important functions, its expression in platelets and certain cells of the immune system suggests that it may play roles in thrombosis and in the immune process.Type: GrantFiled: January 8, 2002Date of Patent: October 19, 2004Assignee: Orth-McNeil Pharmaceutical, Inc.Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Gordon
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Publication number: 20040170973Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease EOS. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease EOS mRNA is expressed in platelets and leukocytes and more specifically eosinophils. Although this protease is abundantly expressed in ovary, retina and stomach, where it may perform important functions, its expression in platelets and certain cells of the immune system suggests that it may play roles in thrombosis and in the immune process.Type: ApplicationFiled: January 8, 2002Publication date: September 2, 2004Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Gordon
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Patent number: 6747134Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease EOS. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease EOS mRNA is expressed in platelets and leukocytes and more specifically eosinophils. Although this protease is abundantly expressed in ovary, retina and stomach, where it may perform important functions, its expression in platelets and certain cells of the immune system suggests that it may play roles in thrombosis and in the immune process. Enzymatically active protease EOS is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.Type: GrantFiled: January 8, 2002Date of Patent: June 8, 2004Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Gordon
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Patent number: 6485957Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease EOS. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease EOS mRNA is expressed in platelets and leukocytes and more specifically eosinophils. Although this protease is abundantly expressed in ovary, retina and stomach, where it may perform important functions, its expression in platelets and certain cells of the immune system suggests that it may play roles in thrombosis and in the immune process.Type: GrantFiled: August 31, 1999Date of Patent: November 26, 2002Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Gordon
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Publication number: 20020168754Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease T. The deduced amino acid sequence encodes a prepro form of 290 amino acids, and its alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease T mRNA is expressed in stomach, testis, retina, fibroblasts, spinal cord, and several regions of the brain. Protease T mRNA is also found in leukocytes and in the Jurkat (ATCC TIB-152) T cell line. Thus, this protease is potentially involved in gastric, testicular, retinal, dematological, neurological/neurodegenerative and/or immunological disorders. The protease T gene maps to human chromosome 16p13.3 which is near the tryptase locus. Enzymatically active protease T, we have generated, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.Type: ApplicationFiled: January 7, 2002Publication date: November 14, 2002Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Grodon
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Publication number: 20020164767Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease C-E. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease C-E mRNA is expressed in pancreas, placenta, prostate, small intestine, stomach, spleen, fibroblasts and epidermis, as well as in certain regions of the brain i.e., cerebellum, cerebral cortex, pituitary and hippocampus. Enzymatically active protease C-E, as produced using the methodologies described herein, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.Type: ApplicationFiled: January 7, 2002Publication date: November 7, 2002Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Grodon
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Publication number: 20020146805Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease T. The deduced amino acid sequence encodes a prepro form of 290 amino acids, and its alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease T mRNA is expressed in stomach, testis, retina, fibroblasts, spinal cord, and several regions of the brain. Protease T mRNA is also found in leukocytes and in the Jurkat (ATCC TIB-152) T cell line. Thus, this protease is potentially involved in gastric, testicular, retinal, dematological, neurological/neurodegenerative and/or immunological disorders. The protease T gene maps to human chromosome 16p13.3 which is near the tryptase locus. Enzymatically active protease T, we have generated, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.Type: ApplicationFiled: January 7, 2002Publication date: October 10, 2002Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Grodon
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Publication number: 20020142447Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease EOS. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease EOS mRNA is expressed in platelets and leukocytes and more specifically eosinophils. Although this protease is abundantly expressed in ovary, retina and stomach, where it may perform important functions, its expression in platelets and certain cells of the immune system suggests that it may play roles in thrombosis and in the immune process.Type: ApplicationFiled: January 8, 2002Publication date: October 3, 2002Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Gordon
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Publication number: 20020142446Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease EOS. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease EOS mRNA is expressed in platelets and leukocytes and more specifically eosinophils. Although this protease is abundantly expressed in ovary, retina and stomach, where it may perform important functions, its expression in platelets and certain cells of the immune system suggests that it may play roles in thrombosis and in the immune process.Type: ApplicationFiled: January 8, 2002Publication date: October 3, 2002Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Gordon
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Patent number: 6458564Abstract: Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease T. The deduced amino acid sequence encodes a prepro form of 290 amino acids, and its alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease T mRNA is expressed in stomach, testis, retina, fibroblasts, spinal cord, and several regions of the brain. Protease T MRNA is also found in leukocytes and in the Jurkat (ATCC TIB-152) T cell line. Thus, this protease is potentially involved in gastric, testicular, retinal, dematological, neurological/neurodegenerative and/or immunological disorders. The protease T gene maps to human chromosome 16p13.3 which is near the tryptase locus. Enzymatically active protease T, we have generated, is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators.Type: GrantFiled: August 31, 1999Date of Patent: October 1, 2002Assignee: Ortho-McNeil Pharmaceutical, Inc.Inventors: Andrew Darrow, Jenson Qi, Patricia Andrade-Grodon