Abstract: A method for modulating an immune system in a subject in need thereof, comprising: administering to a subject an effective amount of a pharmaceutical composition comprising an Antrodia cinnamomea composition, wherein the Antrodia cinnamomea composition comprises: 50 wt % to 100 wt % of Antrodia cinnamomea mycelium; and 0 wt % to 50 wt % of an extract of fruiting body of Antrodia cinnamomea.

Abstract: A solid-state fermentation method is provided. The method is provided for edible and medicinal microorganisms. A commensurate device is used for processing sterilization, inoculation, cultivation, drying, and collection. Cultivation substrates are filled in cultivation plates and placed on trays of a movable layer rack in a reaction fermenter for fermentation. Inner pipes provide inoculation, fluid nutrient, and air for fermentation of microorganisms. The reaction fermenter is accompanied with a dry circulation unit and a production collection unit for drying and collection. The solid-state fermentation processes are thus effectively integrated without the need of transferring fermented products between stations, which largely reduces contamination rate. Even more, there is no need to purchase automatic production equipments of high mechanical technologies.

Abstract: A solid-state fermentation method is provided. The method is provided for edible and medicinal microorganisms. A commensurate device is used for processing sterilization, inoculation, cultivation, drying, and collection. Cultivation substrates are filled in cultivation plates and placed on trays of a movable layer rack in a reaction fermenter for fermentation. Inner pipes provide inoculation, fluid nutrient, and air for fermentation of microorganisms. The reaction fermenter is accompanied with a dry circulation unit and a production collection unit for drying and collection. The solid-state fermentation processes are thus effectively integrated without the need of transferring fermented products between stations, which largely reduces contamination rate. Even more, there is no need to purchase automatic production equipments of high mechanical technologies.

Abstract: A bioactive compound obtained from A. cinnamomea mycelium is prepared. The A. cinnamomea mycelium is solid-state cultivated. The bioactive compound is 2,3,6-trimethoxy-4-methylphenol and is called Leader 1. Leader 1 effectively suppresses movement, migration and invasion of lung cancer cells. Leader 1 achieves the effect of anti-metastasis and shows excellent resistance to physiological activity and mechanism on cancer metastasis.