Abstract: Provided are a method for manufacturing a pharmaceutical composition for the treatment of spinal cord injury, and a method for treating spinal cord injury administering to a subject in need thereof the pharmaceutical composition. The method fo enables a spinal cord injury patient to be treated in a manner which is non-invasive to the spinal cord.

Abstract: Provided are a composition for inducing direct conversion from a somatic cell into a motor neuron, a motor neuron induced through direct conversion by introducing the composition into a somatic cell, a pharmaceutical composition for the prevention or treatment of nervous system disease and injury, a cell therapeutic agent, a composition for screening for a drug for the prevention or treatment of nervous system disease and injury, and a 3D printing biomaterial composition for constructing artificial tissue. When a composition of one aspect is used, differentiation from a somatic cell into a motor neuron can be efficiently induced through the expression of direct conversion inducers without going through the pluripotency stage of dedifferentiated stem cells. Thus, nervous system disease and injury can be effectively prevented and treated using the composition.

Abstract: The present invention relates to a composition for inducing direct conversion from a somatic cell into one or more kinds selected from the group consisting of an induced Hepatic stem cell (iHSC), a hepatocyte, and a cholangiocyte, and a method of direct conversion of a somatic cell into one or more kinds selected from the group consisting of an induced Hepatic stem cell, a hepatocyte, and a cholangiocyte.

Abstract: Provided are a composition and method for inducing direct conversion from a somatic cell into a myeloid cell and use thereof, in which differentiation from a somatic cell into a myeloid cell can be efficiently induced through the expression of a single direct conversion inducer without undergoing the pluripotency stage of induced pluripotent stem cells, and thus, the composition can be widely used as an effective preventive and therapeutic agent for immune diseases.

Abstract: The present invention relates to a composition for inducing direct transdifferentiation into oligodendrocyte progenitor cells (OPCs) from somatic cells, the composition containing at least one protein selected from the group consisting of direct transdifferentiation factors OCT4, SOX1, SOX2, SOX10, OLIG2, NKX2.2, and NKX6.

Abstract: Provided are a hydrogel patch, a method of preparing the same, and a composition for the treatment of spinal cord injury including the hydrogel patch. The hydrogel patch enables a spinal cord injury patient to be treated in a manner which is non-invasive to the spinal cord.

Abstract: The present invention relates to a composition for inducing direct transdifferentiation of a somatic cell into a vascular progenitor cell and a use thereof and, more specifically, to a composition for inducing direct transdifferentiation of a somatic cell into a vascular progenitor cell, a pharmaceutical composition for the prevention or treatment of ischemic vascular diseases, a cell therapeutic agent for the prevention or treatment of ischemic vascular diseases, a composition for screening a therapeutic drug for ischemic vascular diseases, a 3D printing biological material composition for the production of an artificial tissue for the treatment of ischemic vascular diseases, and a method for direct transdifferentiation of a somatic cell into a vascular progenitor cell.

Abstract: The present invention relates to a composition for inducing direct conversion from a somatic cell into one or more kinds selected from the group consisting of an induced Hepatic stem cell (iHSC), a hepatocyte, and a cholangiocyte, and a method of direct conversion of a somatic cell into one or more kinds selected from the group consisting of an induced Hepatic stem cell, a hepatocyte, and a cholangiocyte.

Abstract: The present invention relates to a composition for inducing direct transdifferentiation of a somatic cell into a vascular progenitor cell and a use thereof and, more specifically, to a composition for inducing direct transdifferentiation of a somatic cell into a vascular progenitor cell, a pharmaceutical composition for the prevention or treatment of ischemic vascular diseases, a cell therapeutic agent for the prevention or treatment of ischemic vascular diseases, a composition for screening a therapeutic drug for ischemic vascular diseases, a 3D printing biological material composition for the production of an artificial tissue for the treatment of ischemic vascular diseases, and a method for direct transdifferentiation of a somatic cell into a vascular progenitor cell.

Abstract: The present invention relates to a method of generating an induced pluripotent stem (iPS) cell comprising the step of introducing into a target cell one or two coding sequences each giving rise upon transcription to a factor that contributes to the reprogramming of said target cell into an induced pluripotent stem cell and selected from Oct3/4 or a factor belonging to the Myc, Klf and Sox families of factors, wherein the target cell endogenously expresses at least the factors that are not encoded by the coding sequences to be introduced and selected from Oct3/4 or factors belonging to the Myc, Klf and Sox families of factors, and wherein the cell resulting from the introduction of the one or two coding sequences expresses the combination of factor Oct3/4 and at least one factor of each family of factors selected from the group of Myc, Klf and Sox.

Abstract: The present invention relates to a composition for inducing direct transdifferentiation into oligodendrocyte progenitor cells (OPCs) from somatic cells, the composition containing at least one protein selected from the group consisting of direct transdifferentiation factors OCT4, SOX1, SOX2, SOX10, OLIG2, NKX2.2, and NKX6.

Abstract: The present invention relates to a method of generating an induced pluripotent stem (iPS) cell comprising the step of introducing into a target cell one or two coding sequences each giving rise upon transcription to a factor that contributes to the reprogramming of said target cell into an induced pluripotent stem cell and selected from Oct3/4 or a factor belonging to the Myc, Klf and Sox families of factors, wherein the target cell endogenously expresses at least the factors that are not encoded by the coding sequences to be introduced and selected from Oct3/4 or factors belonging to the Myc, Klf and Sox families of factors, and wherein the cell resulting from the introduction of the one or two coding sequences expresses the combination of factor Oct3/4 and at least one factor of each family of factors selected from the group of Myc, Klf and Sox.

Abstract: The present invention relates to a method of generating an induced pluripotent stem (iPS) cell comprising the step of introducing into a target cell one or two coding sequences each giving rise upon transcription to a factor that contributes to the reprogramming of said target cell into an induced pluripotent stem cell and selected from Oct3/4 or a factor belonging to the Myc, Klf and Sox families of factors, wherein the target cell endogenously expresses at least the factors that are not encoded by the coding sequences to be introduced and selected from Oct3/4 or factors belonging to the Myc, Klf and Sox families of factors, and wherein the cell resulting from the introduction of the one or two coding sequences expresses the combination of factor Oct3/4 and at least one factor of each family of factors selected from the group of Myc, Klf and Sox.

Abstract: A filter device for a water purifier including a filter unit having a flange having an inlet, an outlet, an optional discharge port, opposite engaging protrusions, and opposite engaging recesses; a connecting member fitted into the flange so as to be connected with the inlet, the outlet, and optional discharge port and having inner communicating passages so as to be connected with respective connecting holes, a cap member fitted around the flange to cover the connecting member and having on an outer circumference connecting ports communicating with the respective connecting holes, the cap member having opposite engaging holes corresponding to the engaging protrusions and opposite engaging grooves corresponding to the engaging recesses, and a fixing member engaging on an inner end with the engaging recess through the engaging groove.

Abstract: A method and apparatus for representing a user device and a service as social objects include: registering user information; receiving social Web service account information of the user from a social Web service, and registering the social Web service account information in relation to the user information; and receiving information about the user device and information about services executed in the user device, and registering the received information in relation to the user information.

Abstract: An easy-fit filter device for a water purifier including a filter unit having a flange having an inlet, an outlet, opposite engaging protrusions, and opposite engaging recesses, a connecting member fitted into the flange so as to be connected with the inlet and the outlet and having inner communicating passages so as to be connected with respective connecting holes, a cap member fitted around the flange to cover the connecting member and having on an outer circumference connecting ports communicating with the respective connecting holes, the cap member having opposite engaging holes corresponding to the engaging protrusions and opposite engaging grooves corresponding to the engaging recesses, and a fixing member engaging on an inner end with the engaging recess through the engaging groove.

Abstract: The present invention relates to a method of generating an induced pluripotent stem (iPS) cell comprising the step of introducing into a target cell one or two coding sequences each giving rise upon transcription to a factor that contributes to the reprogramming of said target cell into an induced pluripotent stem cell and selected from Oct3/4 or a factor belonging to the Myc, Klf and Sox families of factors, wherein the target cell endogenously expresses at least the factors that are not encoded by the coding sequences to be introduced and selected from Oct3/4 or factors belonging to the Myc, Klf and Sox families of factors, and wherein the cell resulting from the introduction of the one or two coding sequences expresses the combination of factor Oct3/4 and at least one factor of each family of factors selected from the group of Myc, Klf and Sox.

Abstract: A method and apparatus for updating data, the method including: receiving a forced update command to forcibly update at least one of a first digital rights management (DRM) module and a first device key stored in the device; receiving a DRM package including at least one of a second DRM module and a second device key based on the forced update command; and updating the at least one of the first DRM module and the first device key based on the received DRM package.