Abstract: A device for printing a droplet onto a substrate includes: a droplet generating member which is needle-shaped and comprises a receiving portion disposed vertically to receive a solution, and a discharge hole connected to the receiving portion and formed on a bottom of the receiving portion so that the solution can be discharged from the receiving portion; a substrate disposed below the droplet generating member, the substrate includes a target portion to which the droplet discharged from the discharge hole of the droplet generating member is dropped and attached; a voltage applier applying a voltage to the droplet so that the droplet can be dropped onto the target portion of the substrate; a volume measuring unit measuring the volume of the droplet; and a droplet control unit maintaining the volume of the droplet at a predetermined level based on the measured volume of the droplet.

Abstract: A device and method for printing biomolecules on a substrate uses an electric charge concentration effect. The device overcomes limitations of the material and surface characteristics of a substrate, enables accurate dropping of a biomolecular droplet onto a target surface of the substrate, prevents electric discharge, and thus allows the manufacturing of a high density biochip by depositing numerous biomolecular droplets, which are small in size and volume, onto a substrate. The device includes: a needle-shaped electric field forming electrode; a substrate which is grounded and disposed below the electric field forming electrode, the substrate including a target surface; and an open circuit type voltage applying unit which supplies first electric charges to the electric field forming electrode to drop the biomolecular droplet onto the target surface of the substrate.

Abstract: Disclosed is a data transmitting circuit and a method based on a differential value data encoding to reduce a data transmitting time by transmitting an encoded differential value. The circuit comprises an encoder for encoding and outputting a differential value between a currently transmitted data value and a previously transmitted data value, wherein the encoder inverts a phase of one output signal among 2n(namely, N)-output signals in response to n-bit input value and outputs an encoded data value; and a decoder for decoding the output value of the encoder and restoring the original data value, wherein the decoder restores the original data value by adding an output value from the encoder and the previous original data value.

Abstract: Disclosed is a method for detecting nucleic acid hybridization by using intercalator binding to hybridized nucleic acid, wherein oxidation-reduction of transition metallic complex is induced to cause electrochemiluminescence, thereby providing a method for detecting nucleic acid hybridization without a special labeling.

Abstract: Provided is a device for printing a biomolecule solution onto a substrate using an electrohydrodynamic (EHD) effect. The device can deposit drops of the biomolecule solution with small size and volume and print more of the biomolecule solution onto a substrate, thereby enabling the manufacture of a high density biochip.

Abstract: Provided is a method of removing a nucleic acid amplification inhibitor from a biological sample. The method includes contacting the biological sample to a carboxyl group-coated solid support. Provided is also a micro-PCR system including a sample pretreatment chamber including a carboxyl group-coated solid support; a PCR chamber; and a channel connecting the sample pretreatment chamber and the PCR chamber.

Abstract: Disclosed is a method for detecting nucleic acid hybridization by using intercalator binding to hybridized nucleic acid, wherein oxidation-reduction of transition metallic complex is induced to cause electrochemiluminescence, thereby providing a method for detecting nucleic acid hybridization without a special labeling.

Abstract: Provided is a method of purifying nucleic acids using hydrogen bonding and an electric field, including: bringing a sample containing target nucleic acids into contact with an electrode coated with a material capable of forming hydrogen bonds with the target nucleic acids; applying a positive voltage to the electrode to move the target nucleic acids closer to the electrode so as to form hydrogen bonds with the material on the electrode; washing the electrode; and applying to the electrode a negative voltage to elute the bound target nucleic acids. According to the method, selectivity to nucleic acids and proteins increases due to hydrogen bonding, nucleic acid purification is possible within a short time through an electric field, and the bound nucleic acids can be efficiently eluted.

Abstract: An apparatus for and method of purifying nucleic acids of cells or viruses are provided. The nucleic acid purification apparatus includes: a cell lysis capillary having a sample inlet through which samples, magnetic beads, and a solid support are introduced; a vibrator attached to the capillary and mixing the samples, magnetic beads, and solid support in the capillary; a laser generator attached to the capillary and irradiating a laser beam onto the capillary; a magnetic force generator attached to the capillary and fixing the magnetic beads to a capillary wall; a waste chamber attached to the capillary and discharging a lysate; an elution buffer chamber attached to the capillary and eluting nucleic acids from the solid support having nucleic acids bound thereto; and a neutralization buffer chamber attached to the capillary and supplying a neutralization buffer for neutralizing the eluted nucleic acid solution.

Abstract: An apparatus and method for purification of nucleic acids of cells or viruses are provided. The nucleic acid purification apparatus includes: a cell lysis capillary having a sample inlet through which samples and magnetic beads are introduced; a vibrator attached to the capillary and mixing the samples and the magnetic beads in the capillary; a laser generator attached to the capillary and supplying a laser to the capillary; and a magnetic force generator attached to the capillary and fixing the magnetic beads to a capillary wall. According to the method and apparatus, PCR yield can be increased since PCR inhibitors can be readily removed by means of a phase separation in a capillary. The use of an electromagnet ensures the removal of the PCR inhibitors. In addition, since cell lysis and DNA purification process can be simultaneously performed, LOC steps can be reduced.

Abstract: Disclosed is a mixed-type adder with optimized design costs. The mixed-type adder includes I sub adders, (where, I is a positive number larger than 1). An overall bit width of the mixed-type adder is divided into I bit groups which are respectively allocated to the I sub adders. The I sub adders have different carry propagation schemes and are connected in series through a carry signal.

Abstract: A method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser are provided. According to the method and apparatus for a rapid disruption of cells or viruses using micro magnetic beads and a laser, cell lysis within 40 seconds is possible, the apparatus can be miniaturized using a laser diode, a DNA purification step can be directly performed after a disruption of cells or viruses, and a solution containing DNA can be transferred to a subsequent step after cell debris and beads to which inhibitors of a subsequent reaction are attached are removed with an electromagnet. In addition, by means of the cell lysis chip, an evaporation problem is solved, vibrations can be efficiently transferred to cells through magnetic beads, a microfluidics problem on a rough surface is solved by hydrophobically treating the inner surface of the chip, and the cell lysis chip can be applied to LOC.

Abstract: Disclosed is a microfluidic bio sample processing apparatus including a processing module configured for processing the bio sample and having a hole through which the processed bio sample, a solution for processing the bio sample or both flow, a board having a flowing channel connected with the hole so as to allow the bio sample, the solution for processing the bio sample or both to flow between processing modules and a bonding feature for bonding the processing module with the board. The processing modules are configured to be assembled and/or disassembled onto or from the board so that the processing apparatus is adapted to various kinds of bio samples having different processing steps.

Abstract: Disclosed is a data transmitting circuit and a method based on a differential value data encoding to reduce a data transmitting time by transmitting an encoded differential value. The circuit comprises an encoder for encoding and outputting a differential value between a currently transmitted data value and a previously transmitted data value, wherein the encoder inverts a phase of one output signal among 2n(namely, N)-output signals in response to n-bit input value and outputs an encoded data value; and a decoder for decoding the output value of the encoder and restoring the original data value, wherein the decoder restores the original data value by adding an output value from the encoder and the previous original data value.

Abstract: A device and a method for printing biomolecules onto a substrate using an electrohydrodynamic (EHD) effect are provided.

Abstract: A method for amplifying a nucleic acid using a solid phase material coated with a carboxyl group or an amino group is provided. The method includes contacting a mixture of a nucleic acid containing sample and a salt solution with the solid phase material coated with a carboxyl group or an amino group to form a nucleic acid-solid phase material complex, washing the nucleic acid-solid phase material complex with a wash buffer, and adding a reaction solution for amplifying a nucleic acid to the nucleic acid-solid phase material complex to perform an amplification reaction.

Abstract: A system and method of replacing a missing genotyping data are provided. The method includes: constructing a sample group consisting of a genotyping data with respect to SNP sites of at least one gene samples; comparing a similarity between a sample of the sample group having a missing genotyping data of an SNP site with the other samples of the sample group, and selecting a predetermined number of the samples in order of high similarity; and checking a genotyping data having a greatest frequency occurring in an SNP site disposed at the same position as the SNP site having the missing genotyping data among the selected samples, and replacing the missing genotyping data with the genotyping data having the greatest frequency. It is possible to prevent an incorrect analysis result due to data mismatch, which is caused by data loss.

Abstract: A spotting device for manufacturing a DNA microarray and a spotting method using the same are provided.

Abstract: Provided is a patch for a reaction chamber of a microarray, which includes a support means provided with a sample inlet and an adhesive means adhering to the support means and providing an adhesive strength capable of being attached to a microarray substrate, wherein the adhesive means has stacked adhesive means supports having both surfaces to which an adhesive material is deposited and a first adhesive material located between the adhesive means support and the adhesive means support or between the adhesive means support and the support means has 33 oz/in greater adhesive strength (according to ASTM D3330 Method), based on an adhesive strength to steel, than a second adhesive material located between the patch and the microarray substrate.

Abstract: Disclosed is a method for detecting nucleic acid hybridization by using intercalator binding to hybridized nucleic acid, wherein oxidation-reduction of transition metallic complex is induced to cause electrochemiluminescence, thereby providing a method for detecting nucleic acid hybridization without a special labeling.