Abstract: The present invention provides a microsphere composition for contraceptive microneedles and contraceptive microneedles comprising the same. The microsphere composition for contraceptive microneedles according to the present invention encapsulates a drug stably, exhibits sustained-release of the drug for at least one week, and has a particle size (Dv90) suitable for use in microneedles. The contraceptive microneedles according to the present invention offer convenient administration with once-weekly use, superior skin drug permeability allowing for short attachment times, and sustained-release of the drug for at least one week. The contraceptive microneedle patch of the present invention provides sustained-release of the drug for at least one week even with short attachment times, making it useful as a female contraceptive.

Abstract: Microneedles comprising surface-modified microspheres which exhibit improved residence time in body and superior sustained-release effect, and are suitable for the treatment of diseases requiring continuous drug administration due, and a method of preparing the same, are disclosed herein. Microneedles comprising surface-modified microspheres containing a drug according to the present invention exhibit improved residence time in the body and an superior sustained-release effects, and are therefore useful for treatment of conditions and diseases requiring continuous drug administration.

Abstract: Microneedles comprising hormone-containing surface-modified microspheres which exhibit improved residence time in the body and superior sustained-release effect, and a method of preparing the same, are disclosed herein. Microneedles including surface-modified microspheres containing a hormone according to the present invention exhibit improved residence time in the body and superior sustained-release effect, and are therefore useful for a transdermal delivery system for delivering a hormone requiring continuous administration.

Abstract: The present disclosure relates to cerium oxide abrasive particles and a polishing slurry composition, and more particularly, to cerium oxide abrasive particles comprising: an element cerium; and a modifier and satisfying the agglomeration ratios calculated from the relational expressions of the primary particle sizes and the secondary particle sizes, and a polishing slurry composition comprising the same.

Abstract: Provided is a new cerium-based particle and a polishing slurry composition including the same. The new cerium-based particle may include a self-assembly of fine particles and an organic material.

Abstract: The present invention relates to microstructure formulation techniques for botulinum toxin. The microstructure formulation techniques for botulinum toxin according to the present invention make it possible to precisely control the concentration of botulinum toxin and to alleviate the pain occurring when botulinum toxin is administered into the human body, and also enable botulinum toxin to be accurately administered to a desired position. Thus, the present invention is expected to greatly contribute to the safe and convenient medical use of botulinum toxin.

Abstract: The present invention relates to microstructure formulation techniques for botulinum toxin. The microstructure formulation techniques for botulinum toxin according to the present invention make it possible to precisely control the concentration of botulinum toxin and to alleviate the pain occurring when botulinum toxin is administered into the human body, and also enable botulinum toxin to be accurately administered to a desired position. Thus, the present invention is expected to greatly contribute to the safe and convenient medical use of botulinum toxin.

Abstract: The present invention relates to microstructure formulation techniques for botulinum toxin. The microstructure formulation techniques for botulinum toxin according to the present invention make it possible to precisely control the concentration of botulinum toxin and to alleviate the pain occurring when botulinum toxin is administered into the human body, and also enable botulinum toxin to be accurately administered to a desired position. Thus, the present invention is expected to greatly contribute to the safe and convenient medical use of botulinum toxin.

Abstract: Provided are micro-needles and a micro-needle patch for transdermal delivery of a pharmaceutical, medical, or cosmetic substance. The micro-needle may include a biocompatible matrix having a micro-needle-like shape; and porous particles provided at at least a portion of a surface or the interior of the biocompatible matrix.

Abstract: The present invention relates to microstructure formulation techniques for botulinum toxin. The microstructure formulation techniques for botulinum toxin according to the present invention make it possible to precisely control the concentration of botulinum toxin and to alleviate the pain occurring when botulinum toxin is administered into the human body, and also enable botulinum toxin to be accurately administered to a desired position. Thus, the present invention is expected to greatly contribute to the safe and convenient medical use of botulinum toxin.

Abstract: Provided are micro-needles and a micro-needle patch for transdermal delivery of a pharmaceutical, medical, or cosmetic substance. The micro-needle may include a biocompatible matrix having a micro-needle-like shape; and porous particles provided at at least a portion of a surface or the interior of the biocompatible matrix.