Abstract: Provided are a tricyclodecane dimethanol composition, in which a ratio of structural isomers is controlled, and a preparation method thereof.

Abstract: Disclosed are novel compounds of Chemical Formula 1, optical isomers of the compounds, and pharmaceutically acceptable salts of the compounds or the optical isomers. The compounds, isomers, and salts exhibit excellent activity as GLP-1 receptor agonists. In particular, they, as GLP-1 receptor agonists, exhibit excellent glucose tolerance, thus having a great potential to be used as therapeutic agents for metabolic diseases. Moreover, they exhibit excellent pharmacological safety for cardiovascular systems.

Abstract: According to the embodiments disclosed herein, in a press-fitting test for measuring physical properties of a test object by pressing an indenter against the test object and measuring the load and displacement, the measured displacement value is corrected in real time in consideration of the amount of deformation according to the load of the load cell, and thus an accurate load-displacement curve can be derived, even when the amount of deformation of the load cell is included in a measured value of a displacement sensor.

Abstract: The present invention relates to a phosphine precursor for the preparation of a quantum dot, and a quantum dot prepared therefrom. Using the phosphine precursor for the preparation of a quantum dot of the present invention, a quantum dot with improved luminous efficiency and higher luminous color purity can be provided.

Abstract: An apparatus and a method of manufacturing mesoporous silica are provided. The apparatus includes a mount, a reactor rotatably coupled to the mount, in which mixed solution of surfactant, water and acid is to be poured, an impeller installed to the reactor and rotating to stir the mixed solution, and a heating unit installed to cover an outer surface of the reactor thereby heating the reactor.

Abstract: An apparatus and a method of manufacturing mesoporous silica are provided. The apparatus includes a mount, a reactor rotatably coupled to the mount, in which mixed solution of surfactant, water and acid is to be poured, an impeller installed to the reactor and rotating to stir the mixed solution, and a heating unit installed to cover an outer surface of the reactor thereby heating the reactor.

Abstract: A medical product containing either an active ingredient of propolis which is a natural antibiotic or a grapefruit seed extract, and a manufacturing method thereof are provided. The medical product is impregnated with a solution of CAPE (caffeic acid phenethyl ester) or pinocembrin, which is an active ingredient of propolis having antibacterial effects, to increase the antibacterial activity of the medical product due to antibacterial compounds contained in the active component, or the medical product is impregnated with a solution of a grapefruit seed extract such that the extract can exhibit antibacterial activity in the medical product.

Abstract: The present invention relates to a protein-binding material including a mesoporous silica and a method for selectively separating and purifying using the protein-binding material. More specifically, the present invention relates to a method of preparing a magnetic mesoporous silica responding to a magnetic field by adsorbing a precursor of a transition metal or its ion, such as an iron (Fe) precursor, onto a mesoporous silica, and to a protein-binding material prepared by coating the surface of the magnetic mesoporous silica with a transition metal or its ion so as to be capable of binding to a specific protein labeled with histidine, and also to a method of selectively separating and purifying a specific protein using the protein-binding material.

Abstract: Provided are an organic-inorganic hybrid scaffold with surface-immobilized nano-hydroxyapatite, and a method for the fabrication thereof. The scaffold is fabricated by reacting an acid group present on a surface of nano-hydroxyapatite with a primary amine present on a surface of a polymer support in the presence of EDC (1-ethyl-3-dimethylaminopropyl carbodiimide) to immobilize nano-hydroxyapatite onto the surface of the polymer support. The surface of nano-hydroxyapatite is previously grafted with poly(ethylene glycol methacrylate phosphate) (PolyEGMP) having phosphonic acid functionality or with a polymer having carboxylic acid functionality.

Abstract: Disclosed is a method of preparing mesoporous silica nanoparticles using hydrothermal synthesis, including adding a transition metal when reacting a surfactant and a silica precursor. The mesoporous silica nanoparticles are high functional particles able to be used as an adsorbent, a sensor, a membrane, a catalyst and a catalyst support, thanks to their large surface area and nano-sized pores. The mesoporous silica nanoparticles are functionally advantageous in terms of increased material diffusion rate and reactivity, easy recycling after use as a catalyst and slow inactivation, compared to conventional mesoporous silica, and are prepared through a very simple process among methods of controlling the particle size of mesoporous silica to a nano size.

Abstract: A method of manufacturing a medical antimicrobial suture having a grapefruit extract which is a grapefruit seed extract including naringin, ascorbic acid or citral is provided. The method includes preparing grapefruit extract solution with a concentration of 500 to 2000 ppm by mixing the grapefruit extract with methanol solvent; and impregnating a biodegradable monofilament suture with the grapefruit extract solution for more than 360 minutes. The grapefruit extract is continuously released in a body for 70 hours after the antimicrobial suture is inserted into the body.

Abstract: A medical product containing either an active ingredient of propolis which is a natural antibiotic or a grapefruit seed extract, and a manufacturing method thereof are provided. The medical product is impregnated with a solution of CAPE (caffeic acid phenethyl ester) or pinocembrin, which is an active ingredient of propolis having antibacterial effects, to increase the antibacterial activity of the medical product due to antibacterial compounds contained in the active component, or the medical product is impregnated with a solution of a grapefruit seed extract such that the extract can exhibit antibacterial activity in the medical product.

Abstract: The present invention relates to a protein-binding material including a mesoporous silica and a method for selectively separating and purifying using the protein-binding material. More specifically, the present invention relates to a method of preparing a magnetic mesoporous silica responding to a magnetic field by adsorbing a precursor of a transition metal or its ion, such as an iron (Fe) precursor, onto a mesoporous silica, and to a protein-binding material prepared by coating the surface of the magnetic mesoporous silica with a transition Metal or its ion so as to be capable of binding to a specific protein labeled with histidine, and also to a method of selectively separating and purifying a specific protein using the protein-binding material.

Abstract: The present disclosure provides a biochip module having a ceramic laminate structure which uses advantages of ceramic and enables a reduction in a chip area, and a method of manufacturing the same. The biochip module includes a first ceramic layer mixing bacterial water with magnetic beads to which ligands capturing bacteria are attached, a second ceramic layer separating the magnetic beads capturing bacteria from the water, and a third ceramic layer detecting the number of bacteria captured by the magnetic beads.

Abstract: There is provided an antimicrobial suture for medical use characterized in that the suture contains the grapefruit extract, and a manufacturing method thereof. The antimicrobial suture for medical use of the present invention may prevent from the pathogen infection being occurred by which the suture contains the grapefruit extract having the antimicrobial effect and provide the antimicrobial effect.

Abstract: Disclosed is a method of preparing mesoporous silica nanoparticles using hydrothermal synthesis, including adding a transition metal when reacting a surfactant and a silica precursor. The mesoporous silica nanoparticles are high functional particles able to be used as an adsorbent, a sensor, a membrane, a catalyst and a catalyst support, thanks to their large surface area and nano-sized pores. The mesoporous silica nanoparticles are functionally advantageous in terms of increased material diffusion rate and reactivity, easy recycling after use as a catalyst and slow inactivation, compared to conventional mesoporous silica, and are prepared through a very simple process among methods of controlling the particle size of mesoporous silica to a nano size.

Abstract: Provided are an organic-inorganic hybrid scaffold with surface-immobilized nano-hydroxyapatite, and a method for the fabrication thereof. The scaffold is fabricated by reacting an acid group present on a surface of nano-hydroxyapatite with a primary amine present on a surface of a polymer support in the presence of EDC (1-ethyl-3-dimethylaminopropyl carbodiimide) to immobilize nano-hydroxyapatite onto the surface of the polymer support. The surface of nano-hydroxyapatite is previously grafted with poly(ethylene glycol methacrylate phosphate) (PolyEGMP) having phosphonic acid functionality or with a polymer having carboxylic acid functionality.