Patents by Inventor Jeongsik Yong

Jeongsik Yong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and Methods for Regulating Cytochrome c-Mediated Apoptosis by tRNA
    Publication number: 20150197729
    Abstract: The invention relates to the discovery that tRNA is a potent regulator of cell survival. tRNA regulates the interaction between cytochrome c and Apaf-1 and subsequently Apaf-1 oligomerization into an apoptosome which in turn recruits and oligomerizes the caspase cascade which ultimately leads to cell death. Accordingly, the present invention provides compositions and methods for regulating cell survival.
    Type: Application
    Filed: March 3, 2015
    Publication date: July 16, 2015
    Inventors: Xiaolu Yang, Yide Mei, Jeongsik Yong
  • Compositions, methods and kits based on small nuclear RNAs
    Patent number: 9040491
    Abstract: The present invention includes methods for modulating the expression of a gene or mRNA in a cell using small nuclear RNAs comprising specific sequence and structural features and further comprising a nucleic acid cargo.
    Type: Grant
    Filed: August 29, 2007
    Date of Patent: May 26, 2015
    Assignee: The Trustees of the University of Pennsylvania
    Inventors: Gideon Dreyfuss, Jeongsik Yong, Tracey (Golembe) Polsky
  • Compositions and Methods for Regulating Cytochrome c-Mediated Apoptosis by tRNA
    Publication number: 20120252718
    Abstract: The invention relates to the discovery that tRNA is a potent regulator of cell survival, tRNA regulates the interaction between cytochrome c and Apaf-1 and subsequently Apaf-1 oligomerization into an apoptosome which in turn recruits and oligomerizes the caspase cascade which ultimately leads to cell death. Accordingly, the present invention provides compositions and methods for regulating cell survival.
    Type: Application
    Filed: October 6, 2010
    Publication date: October 4, 2012
    Inventors: Xiaolu Yang, Yide Mei, Jeongsik Yong
  • Compositions, methods and kits based on small nuclear RNAs
    Publication number: 20080194027
    Abstract: The present invention includes methods for modulating the expression of a gene or mRNA in a cell using small nuclear RNAs comprising specific sequence and structural features and further comprising a nucleic acid cargo.
    Type: Application
    Filed: August 29, 2007
    Publication date: August 14, 2008
    Inventors: Gideon Dreyfuss, Jeongsik Yong, Tracey (Golembe) Polsky