Patents by Inventor Jerôme H.H.V. CUSTERS

Jerôme H.H.V. CUSTERS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200323977
    Abstract: Provided herein are adenoviral nucleic acid sequences and adenoviral vectors comprising said nucleic acid sequences. The provided adenoviral vectors can be used to induce a protective immune response in a subject.
    Type: Application
    Filed: October 30, 2018
    Publication date: October 15, 2020
    Inventors: Taco Gilles UIL, Soumitra ROY, Selina KHAN, Jerôme H.H.V. CUSTERS
  • Publication number: 20190142933
    Abstract: Vectors, vaccines, vaccine compositions and vaccine combinations for use as therapeutics against HPV18 and/or HPV16 are described.
    Type: Application
    Filed: May 1, 2017
    Publication date: May 16, 2019
    Inventors: Evelien M. BUNNIK, Jerôme H.h.v. CUSTERS, Gerrit C. SCHEPER, Selina KHAN, Markus KALLA, Katrin WEIDNER
  • Publication number: 20190083597
    Abstract: The present invention relates to novel vaccines against malaria infections, based on recombinant adenovirus vectors. Described are capsid modified replication deficient adenovirus particle encoding and displaying circumsporozoite (CS) protein NANP-repeats (CSshort) from a malaria-causing parasite, preferably P. falciparum, via a minor capsid protein IX and encoding a heterologous protein as a transgene. In a particular embodiment, said replication incompetent vectors of rare serotypes such as human adenovirus 35 (HAdV35) and human adenovirus 26 (HAdV26) comprise nucleic acid encoding the CS protein, as a transgene, from a malaria-causing parasite and encoding and displaying the NANP-repeat from a malaria-causing parasite (1) directly fused to the protein IX, (2) fused to protein IX via a flexible linker or (3) an alpha-helical viral origin spacer SP1 to ensure both humoral and cellular responses against the selected antigens.
    Type: Application
    Filed: January 19, 2017
    Publication date: March 21, 2019
    Inventors: Jerôme H.H.V. CUSTERS, Jort VELLINGA, Marija VUJADINOVIC, Esmerelda VAN DER HELM
  • Publication number: 20180135075
    Abstract: The invention provides recombinant adenovirus (rAd) and rAd vectors comprising a bidirectional mouse CMV (mCMV) promoter operably linked to a first transgene in one direction and to a second transgene in the opposite direction. The invention also provides methods of making and using such rAd and rAd vectors.
    Type: Application
    Filed: April 12, 2016
    Publication date: May 17, 2018
    Inventors: Kerstin WUNDERLICH, Jerôme H.H.V. CUSTERS, Jort VELLINGA, Barbara Petronella SANDERS
  • Publication number: 20170281747
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
    Type: Application
    Filed: May 22, 2017
    Publication date: October 5, 2017
    Inventors: Evelien M. BUNNIK, Jerome H.H.V. CUSTERS, Gerrit C. SCHEPER, Koen OOSTERHUIS, Taco Gilles UIL, Selina KHAN