Patents by Inventor Jerôme Hubertina Henricus Victor Custers

Jerôme Hubertina Henricus Victor Custers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Poxvirus vectors encoding HIV antigens, and methods of use thereof
    Patent number: 11723970
    Abstract: Poxvirus vectors encoding a synthetic HIV envelope antigen and other HIV antigens, as well as compositions containing such poxvirus vectors and uses of such poxvirus vectors as vaccines to provide improved immunity against HIV, are provided. Also provided are vaccine combinations containing the disclosed poxvirus vectors, adenovirus vectors encoding one or more HIV antigens, and one or more isolated HIV antigenic polypeptides, and methods of using the vaccine combinations to provide improved immunity against HIV.
    Type: Grant
    Filed: December 10, 2021
    Date of Patent: August 15, 2023
    Assignees: Janssen Vaccines & Prevention B. V., Bavarian Nordic A/S
    Inventors: Frank Wegmann, Johannes Petrus Maria Langedijk, Jerôme Hubertina Henricus Victor Custers, Viki Bockstal, Markus Kalla
  • ADENOVIRUS VECTORS AND USES THEREOF
    Publication number: 20220372515
    Abstract: Provided herein are chimeric adenoviral vectors. The provided chimeric adenoviral vectors can be used to induce a protective immune response and/or express a transgene in a subject in need thereof.
    Type: Application
    Filed: October 2, 2020
    Publication date: November 24, 2022
    Inventors: Jerome Hubertina Henricus Victor CUSTERS, Menzo Jans Emko HAVENGA, Monika BALLMANN, Angelique Alida Corina LEMCKERT, Andrew BAKER, Niklas ARNBERG, Gyozo KAJAN
  • Poxvirus Vectors Encoding HIV Antigens, and Methods of Use Thereof
    Publication number: 20220088172
    Abstract: Poxvirus vectors encoding a synthetic HIV envelope antigen and other HIV antigens, as well as compositions containing such poxvirus vectors and uses of such poxvirus vectors as vaccines to provide improved immunity against HIV, are provided. Also provided are vaccine combinations containing the disclosed poxvirus vectors, adenovirus vectors encoding one or more HIV antigens, and one or more isolated HIV antigenic polypeptides, and methods of using the vaccine combinations to provide improved immunity against HIV.
    Type: Application
    Filed: December 10, 2021
    Publication date: March 24, 2022
    Inventors: Frank Wegmann, Johannes Petrus Maria Langedijk, Jerôme Hubertina Henricus Victor Custers, Viki Bockstal, Markus Kalla
  • Poxvirus vectors encoding HIV antigens, and methods of use thereof
    Patent number: 11229693
    Abstract: Poxvirus vectors encoding a synthetic HIV envelope antigen and other HIV antigens, as well as compositions containing such poxvirus vectors and uses of such poxvirus vectors as vaccines to provide improved immunity against HIV, are provided. Also provided are vaccine combinations containing the disclosed poxvirus vectors, adenovirus vectors encoding one or more HIV antigens, and one or more isolated HIV antigenic polypeptides, and methods of using the vaccine combinations to provide improved immunity against HIV.
    Type: Grant
    Filed: June 14, 2018
    Date of Patent: January 25, 2022
    Assignees: Janssen Vaccines & Prevention B.V., Bavarian Nordic A/S
    Inventors: Frank Wegmann, Johannes Petrus Maria Langedijk, Jerôme Hubertina Henricus Victor Custers, Viki Bockstal, Markus Kalla
  • Methods and Compositions for Inducing an Immune Response Against Hepatitis B Virus (HBV)
    Publication number: 20210268104
    Abstract: Provided herein are Modified Vaccinia Ankara (MVA) vectors and adenovirus vectors encoding HBV antigens. Also provided are methods of enhancing an immune response in a human subject by utilizing the MVA and adenovirus vectors encoding HBV antigens in a prime/boost regimen to the enhance the immune response in the human subject.
    Type: Application
    Filed: May 18, 2021
    Publication date: September 2, 2021
    Inventors: Daniel BODEN, Helen HORTON, Jean-Marc Edmond Fernand Marie NEEFS, Soumitra ROY, Jerôme Hubertina Henricus Victor CUSTERS, Roland Christian ZAHN, Markus KALLA
  • Therapeutic HPV16 vaccines
    Patent number: 11040096
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
    Type: Grant
    Filed: January 29, 2020
    Date of Patent: June 22, 2021
    Inventors: Evelien Margaretha Bunnik, Jerôme Hubertina Henricus Victor Custers, Gerrit Christiaan Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan
  • Methods and compositions for inducing an immune response against Hepatitis B Virus (HBV)
    Patent number: 11020476
    Abstract: Provided herein are Modified Vaccinia Ankara (MVA) vectors and adenovirus vectors encoding HBV antigens. Also provided are methods of enhancing an immune response in a human subject by utilizing the MVA and adenovirus vectors encoding HBV antigens in a prime/boost regimen to the enhance the immune response in the human subject.
    Type: Grant
    Filed: December 18, 2018
    Date of Patent: June 1, 2021
    Inventors: Daniel Boden, Helen Horton, Jean-Marc Edmond Fernand Marie Neefs, Soumitra Roy, Jerôme Hubertina Henricus Victor Custers, Roland Christian Zahn, Markus Kalla
  • Therapeutic HPV18 vaccines
    Patent number: 10844096
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: November 24, 2020
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Evelien Margaretha Bunnik, Jerôme Hubertina Henricus Victor Custers, Gerrit Christiaan Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan
  • HPV vaccines
    Patent number: 10744196
    Abstract: The present invention relates to novel vaccines against Human papillomavirus (HPV) infections, based on recombinant capsid-display adenovirus vectors. Described are capsid modified replication deficient adenovirus particles encoding and displaying multiple HPV L2 antigenic fragments, via a minor capsid protein IX, and their use for eliciting an immune response in order to provide protection against infections from multiple HPV types.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: August 18, 2020
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Marija Vujadinovic, Taco Gilles Uil, Koen Oosterhuis, Jort Vellinga, Jerôme Hubertina Henricus Victor Custers
  • THERAPEUTIC HPV16 VACCINES
    Publication number: 20200164057
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
    Type: Application
    Filed: January 29, 2020
    Publication date: May 28, 2020
    Inventors: Evelien Margaretha BUNNIK, Jerôme Hubertina Henricus Victor CUSTERS, Gerrit Christiaan SCHEPER, Koen OOSTERHUIS, Taco Gilles UIL, Selina KHAN
  • POXVIRUS VECTORS ENCODING HIV ANTIGENS, AND METHODS OF USE THEREOF
    Publication number: 20200138938
    Abstract: Poxvirus vectors encoding a synthetic HIV envelope antigen and other HIV antigens, as well as compositions containing such poxvirus vectors and uses of such poxvirus vectors as vaccines to provide improved immunity against HIV, are provided. Also provided are vaccine combinations containing the disclosed poxvirus vectors, adenovirus vectors encoding one or more HIV antigens, and one or more isolated HIV antigenic polypeptides, and methods of using the vaccine combinations to provide improved immunity against HIV.
    Type: Application
    Filed: June 14, 2018
    Publication date: May 7, 2020
    Inventors: Frank WEGMANN, Johannes Petrus Maria LANGEDIJK, Jerôme Hubertina Henricus Victor CUSTERS, Viki BOCKSTAL, Markus KALLA
  • Therapeutic HPV16 vaccines
    Patent number: 10555996
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
    Type: Grant
    Filed: August 8, 2018
    Date of Patent: February 11, 2020
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Evelien Margaretha Bunnik, Jerôme Hubertina Henricus Victor Custers, Gerrit Christiaan Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan
  • HPV VACCINES
    Publication number: 20190240312
    Abstract: The present invention relates to novel vaccines against Human papillomavirus (HPV) infections, based on recombinant capsid-display adenovirus vectors. Described are capsid modified replication deficient adenovirus particles encoding and displaying multiple HPV L2 antigenic fragments, via a minor capsid protein IX, and their use for eliciting an immune response in order to provide protection against infections from multiple HPV types.
    Type: Application
    Filed: July 11, 2017
    Publication date: August 8, 2019
    Inventors: Marija VUJADINOVIC, Taco Gilles UIL, Koen OOSTERHUIS, Jort VELLINGA, Jerôme Hubertina Henricus Victor CUSTERS
  • THERAPEUTIC HPV18 VACCINES
    Publication number: 20190202869
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.
    Type: Application
    Filed: March 19, 2019
    Publication date: July 4, 2019
    Inventors: Evelien Margaretha BUNNIK, Jerôme Hubertina Henricus Victor CUSTERS, Gerrit Christiaan SCHEPER, Koen OOSTERHUIS, Taco Gilles UIL, Selina KHAN
  • METHODS AND COMPOSITIONS FOR INDUCING AN IMMUNE RESPONSE AGAINST HEPATITIS B VIRUS (HBV)
    Publication number: 20190184011
    Abstract: Provided herein are Modified Vaccinia Ankara (MVA) vectors and adenovirus vectors encoding HBV antigens. Also provided are methods of enhancing an immune response in a human subject by utilizing the MVA and adenovirus vectors encoding HBV antigens in a prime/boost regimen to the enhance the immune response in the human subject.
    Type: Application
    Filed: December 18, 2018
    Publication date: June 20, 2019
    Inventors: Daniel BODEN, Helen HORTON, Jean-Marc Edmond Fernand Marie NEEFS, Soumitra ROY, Jerôme Hubertina Henricus Victor CUSTERS, Roland Christian ZAHN, Markus KALLA
  • Therapeutic HPV18 vaccines
    Patent number: 10287323
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.
    Type: Grant
    Filed: September 12, 2017
    Date of Patent: May 14, 2019
    Assignee: Janssen Vaccines & Prevention B.V.
    Inventors: Evelien M. Bunnik, Jerome Hubertina Henricus Victor Custers, Gerrit C. Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan
  • Cold-adapted-viral-attenuation (CAVA) and novel attenuated poliovirus strains
    Patent number: 10238730
    Abstract: A poliovirus (PV) strain was attenuated by a novel method of Cold-Adapted-Viral-Attenuation (CAVA). The resulting recombinant attenuated PV, CAVA-PV, shows wild-type replication at 30° C., but no substantial replication at 37° C. The inability to replicate at 37° C. is defined by an inability to quantify virus during infection at this temperature by titration (infectious units), qPCR (viral RNA) or Electron Microscopy (visual signs of infection). CAVA-PV is genetically stable under production conditions and shows utility for use as the backbone to produce attenuated strains with the same antigenic profile as conventional vaccines by replacing the sequence coding for the capsid of CAVA-PV with sequences coding for capsids of different PV strains. Furthermore, mutations identified in CAVA-PV can be engineered into different, even wild-type and neurovirulent poliovirus background strains to obtain additional CAVA-PV strains.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: March 26, 2019
    Assignee: JANSSEN VACCINES & PREVENTION B.V.
    Inventors: Barbara Petronella Sanders, Jerome Hubertina Henricus Victor Custers, Diana Edo-Matas, Taco Gilles Uil, John A. Lewis
  • THERAPEUTIC HPV16 VACCINES
    Publication number: 20180344841
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV16.
    Type: Application
    Filed: August 8, 2018
    Publication date: December 6, 2018
    Inventors: Evelien Margaretha Bunnik, Jerôme Hubertina Henricus Victor Custers, Gerrit Christiaan Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan
  • THERAPEUTIC HPV18 VACCINES
    Publication number: 20170369534
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.
    Type: Application
    Filed: September 12, 2017
    Publication date: December 28, 2017
    Inventors: Evelien M. BUNNIK, Jerome Hubertina Henricus Victor CUSTERS, Gerrit C. SCHEPER, Koen OOSTERHUIS, Taco Gilles UIL, Selina KHAN
  • Therapeutic HPV18 vaccines
    Patent number: 9790256
    Abstract: Provided is designer nucleic acid constructs and polypeptides that can be used as therapeutic vaccines against HPV18 and/or HPV16.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: October 17, 2017
    Assignee: JANSSEN VACCINES & PREVENTION B.V.
    Inventors: Evelien Margaretha Bunnik, Jerome Hubertina Henricus Victor Custers, Gerrit Christiaan Scheper, Koen Oosterhuis, Taco Gilles Uil, Selina Khan