Abstract: A mechanical circulatory support system for a heart having a cooling element and a method for using the system to treat the effects of a cardiac episode. The support system has a pump comprising a rotor, the rotor having at least one blade. The system also has a catheter having an inner surface and an outer surface, the catheter extending proximally of relative to the pump housing. The outer surface of the catheter is configured to contact blood when disposed within patient vasculature. The outer surface of the catheter comprises a heat transfer surface configured for cooling blood that comes in contact with the outer surface. The support system is operated to provide a temperature selected to cool the circulating blood in contact with the outer surface of the catheter to a temperature selected to reduce or prevent an effect of a cardiac episode.

Abstract: A method and system for improving kidney function of a patient may be provided. The method may include activating a baroreceptor, and improving a flow of blood through vasculature of the patient. This may include positioning a stent at or near a baroreceptor, the stent configured to stretch the vasculature. This may include positioning a lead at or near a baroreceptor, the lead comprising a proximal end and a distal end and an electrode connected to the distal end of the lead, wherein the electrode configured to emit one or more electrical signals, such as an intermittent electrical stimulus or a constant electrical stimulus. The stent may include a tubular body, which may be made of a flexible material.

Abstract: A method for providing a therapeutic treatment to reduce preload may be provided. The method may include placing a ventricular assist device (VAD) at least partially within either the left or right ventricle of a patient, and placing a catheter-based device comprising an adjustable flow restricting element (FRE) such that the FRE is disposed within a superior vena cava (SVC) of the patient. The method may include receiving information from the VAD and/or the catheter-based FRE device, determining a first determined value based on the information, and controlling at least one performance parameter of the VAD and/or the catheter-based device based on the first determined value.

Abstract: A mechanical circulatory support system for a heart having a cooling element and a method for using the system to treat the effects of a cardiac episode. The support system has a pump comprising a rotor, the rotor having at least one blade. The system also has a catheter having an inner surface and an outer surface, the catheter extending proximally of relative to the pump housing. The outer surface of the catheter is configured to contact blood when disposed within patient vasculature. The outer surface of the catheter comprises a heat transfer surface configured for cooling blood that comes in contact with the outer surface. The support system is operated to provide a temperature selected to cool the circulating blood in contact with the outer surface of the catheter to a temperature selected to reduce or prevent an effect of a cardiac episode.

Abstract: Methods and apparatus for determining a contractile reserve of a heart of a patient are provided. The method includes controlling a heart pump to operate at a first speed, determining based on a motor current signal received from a motor when the heart pump is operating at the first speed, a first value for a cardiac contractility metric, controlling the heart pump to operate at a second speed, determining based, at least in part, on the motor current signal received from the motor when the heart pump is operating at the second speed, a second value for the cardiac contractility metric, determining a contractile reserve metric based, at least in part, on the first value and the second value of the cardiac contractility metric, and outputting an indication of the contractile reserve metric on a user interface associated with the heart pump.

Abstract: Methods and systems for extracting patient information from an electronic medical record (EMR) for use in a clinical trial are described. The method includes receiving an indication that a new clinical trial subject has been identified from a subject identification source, retrieving, from an EMR associated with the new clinical trial subject, patient information, processing the retrieved patient information to de-identify the retrieved patient information thereby generating de-identified patient information, and providing a portion of the de-identified patient information as input to an electronic data capture (EDC) system for the clinical trial.

Abstract: A mechanical circulatory support system for a heart having a cooling element and a method for using the system to treat the effects of a cardiac episode. The support system has a pump comprising a rotor, the rotor having at least one blade. The system also has a catheter having an inner surface and an outer surface, the catheter extending proximally relative to the pump housing. The outer surface of the catheter is configured to contact blood when disposed within patient vasculature. The outer surface of the catheter comprises a heat transfer surface configured for cooling blood that comes in contact with the outer surface. The support system is operated to provide a temperature selected to cool the circulating blood in contact with the outer surface of the catheter to a temperature selected to reduce or prevent an effect of a cardiac episode.

Abstract: Systems and method are disclosed involving a pump control module configured to control an intravascular blood pump and display information about the intravascular blood pump, and a blood monitoring module configured to derive a value of a blood parameter from information received about a blood sample, such as information received from a blood monitoring sensor, and display the value of the blood parameter on the first display screen and/or on a second display screen. The system and method may also include predicting other parameters based on, e.g., the information received from the blood sample. The predictions may include, e.g., predictions of heart failure or bleeding events.

Abstract: A monitoring patch including a substrate having an adhesive surface and a plurality of sensors disposed in and/or on the substrate. In some embodiments, the plurality of sensors may include one or more sensors arranged to measure oxygen saturation, a lactate sensor, and one or more impedance cardiography electrodes. In some embodiments, the plurality of sensors may include an accelerometer and a strain gauge, and may be free of at least one sensor of a sensor arranged to measure oxygen saturation, a lactate sensor, or an impedance cardiography electrode.

Abstract: A mechanical circulatory support system for a heart having a cooling element and a method for using the system to treat the effects of a cardiac episode. The support system has a pump having a distal end and a proximal end, the pump comprising a rotor, the rotor having at least one blade. The system also has a catheter having a distal end, a proximal end, and inner surface, and an outer surface, the catheter extending proximally of relative to the pump housing. The outer surface of the catheter is configured to contact blood when disposed within patient vasculature. The outer surface of the catheter comprises a heat transfer surface configured for cooling blood that comes in contact with the outer surface. The cooling element can be either a helix or double helix extending along a catheter surface or a Peltier element on the surface.