Abstract: A multiple-part curable composition, a cured composition formed by combining and reacting the multiple-part curable composition, and a method of providing a cured composition are described. The multiple-part curable composition contains at least a part A and a part B. Part A contains an oxalamido-containing compound while part B contains a derivatized polyethylene imine. The cured composition is an adhesive that is suitable for use as a tissue adhesive.

Abstract: A curable composition is provided comprising a urethane (meth)acrylate oligomer, a urethane (urea) phosphonate ad-hesion promoter, optionally reactive diluents, and an initiator. The use of the urethane (urea) phosphonate adhesion promotor provides better ageing stability and adhesion, as measured by T-peel adhesion test, than the use of other conventional adhesion promotors.

Abstract: Described herein is a method of purifying a target molecule from an aqueous biological composition, the method comprising: (a) contacting a cationic polymer and the aqueous biological composition to form a mixture comprising a bio-polymer complex and the target molecule in a liquid, wherein the bio-polymer complex has an average particle diameter of at least 45 micrometers, (b) adding the mixture to a filtering volume of a vessel, wherein the vessel comprises loosely packed staple fibers; (c) allowing the mixture to separate through the loosely packed staple fiber; and (d) collecting a filtrate comprising the target molecule.

Abstract: Described herein is a method of purifying a target molecule from an aqueous biological composition, the method comprising: (a) contacting a cationic polymer and the aqueous biological composition to form a mixture, the mixture comprising a bio-polymer complex and the target non-binding molecule in a liquid, wherein the bio-polymer complex has an average particle diameter of at least 50 micrometers; (b) providing a filtering unit comprising (i) a housing having an inlet and an outlet, (ii) a porous, continuous filter medium which is fluidly connected to the inlet and the outlet, and (iii) a collection region upstream from the porous, continuous filter medium; (c) adding the mixture to the inlet; and (d) allowing the mixture to separate in the filtering unit, whereby the bio-polymer complex collects in the collection region and the target non-binding molecule passes through the filter medium, and wherein the majority of flow of the liquid through the porous, continuous filter medium is not substantially paralle

Abstract: A polymer matrix composite comprising a porous polymeric network; and a plurality of functional particles distributed within the polymeric network structure, and wherein the polymer matrix composite has an air flow resistance at 25° C., as measured by the “Air Flow Resistance Test,” of less than 300 seconds/50 cm3/500 micrometers; and wherein the polymer matrix composite has a density of at least 0.3 g/cm3; and methods for making the same. The polymer matrix composites are useful, for example, as filters.

Abstract: A multiple-part curable composition, a cured composition formed by combining and reacting the multiple-part curable composition, and a method of providing a cured composition are described. The multiple-part curable composition contains at least a part A and a part B. Part A contains an oxalamido-containing compound while part B contains a derivatized polyethylene imine. The cured composition is an adhesive that is suitable for use as a tissue adhesive.

Abstract: A polymer matrix composite comprising a porous polymeric network; and a plurality of functional particles distributed within the polymeric network structure, and wherein the polymer matrix composite has an air flow resistance at 25° C., as measured by the “Air Flow Resistance Test,” of less than 300 seconds/50 cm3/500 micrometers; and wherein the polymer matrix composite has a density of at least 0.3 g/cm3; and methods for making the same. The polymer matrix composites are useful, for example, as filters.

Abstract: Flow-through processes for purifying a target molecule (e.g., antibodies, enzymes, and hormones, particularly a monoclonal antibody) from a biological solution (e.g., a neutralized viral inactivation pool) in a sample that includes the target molecule, and devices for carrying out such processes.

Abstract: Monomers, polymers formed from such monomers, and articles for biomaterial capture including such polymers, wherein the monomer is represented by the following general Formula (I): CH2?CR1—C(?O)—X—R2—Z—X3—NR3—C(?X2)-X1—R4, wherein: R1 is H or —CH3; R2 is a (hetero)hydrocarbylene; X is —O— or —NH—; X1 is —O—, —S—, —NH—, or a single bond; X2 is —O— or —S—; X3 is —O— or —NR5—; R4 is hydrogen, (hetero)hydrocarbyl, or —N(R3)2; each R3 and R5 is independently hydrogen or a (hetero)hydrocarbyl; and Z is —C(?O)— or —NH—C(?O)—.

Abstract: Described herein is a multilayer article comprising: a. a polymer substrate comprising an abstractable atom; and b. a hydrogel coating thereon wherein the hydrogel coating has a water content of at least 10 wt % and is covalently bonded to the polymer substrate, and wherein the hydrogel coating is derived from an aqueous composition having a pH less than 9.5, the aqueous composition comprising: (a) a hydrophilic monomer selected from at least one of (meth)acrylate or (meth)acrylamide; (b) at least 0.1 wt % of a water-swellable clay; (c) a first initiator, wherein the first initiator is water-soluble and is a Type I photoinitiator; and (d) a second initiator, wherein the initiator is water-soluble and is a Type II photoinitiator; and (e) an acid.

Abstract: Disclosed herein are methods that include contacting a skin surface with a first liquid composition; and then contacting in the skin surface with a cationic coated article loaded with a second liquid composition, while at least some portion of the first liquid composition remains on the skin surface, wherein one or both of the first liquid composition or the second liquid composition includes acrylate copolymer particles dispersed therein, the acrylate copolymer particles including the reaction product of a reaction mixture, the reaction mixture including monomers, the monomers including from about 5 wt % to about 50 wt % of at least one high Tg monomer where the wt % of the high Tg monomer is with respect to the total weight of the monomers in the reaction mixture; and from about 20 wt % to about 80 wt % of at least one low Tg monomer where the wt % of the low Tg monomer is with respect to the total weight of the monomers in the reaction mixture, wherein the particles have a number average diameter of at lea

Abstract: Biotin-containing monomers, polymeric materials formed from the biotin-containing monomers, articles containing the polymeric materials, methods of making the articles, and methods of using the articles are provided. The articles can be used, for example, for affinity capture of biotin-binding proteins, including biotin-binding fusion proteins (i.e., a biotin-binding protein fused to another biomaterial). Articles that contain captured biotin-binding proteins can be further used for affinity capture of various biotin-containing biomaterials such as biotinylated proteins. The articles can also be used, for example, for affinity capture of biotin-binding fusion proteins where the fusion protein includes, for example, an enzyme or antibody.

Abstract: A wipe article includes a substrate, a cationic coating disposed on a surface of the substrate, distributed throughout the substrate, or both. The cationic coating contains a guanidinyl-containing polymer that is crosslinked and bound to the substrate. The substrate includes sponge, nonwoven fabric, or woven fabric. The wipes are useful for removing microorganisms from a microorganism-contaminated surface and also for reducing re-contamination of the cleaned surface or transfer to another surface of the removed microorganisms.

Abstract: Film forming gel compositions, useful in creating conformable and flexible gel bandages, can be formulate from a film-forming polymer, a tackifier, and a volatile solvent. The film forming gels can also include antiseptics, cationic polymer coagulants, fillers, and other additives. The gel compositions form relatively thick films when dried on tissue, and can exhibit enhanced breathability to promote wound healing.

Abstract: An article that includes a functionalized copolymer and the use thereof, particularly in a process for binding biomaterials, such as in a process for separating aggregated proteins from monomeric proteins in a biological solution; wherein the article includes: a) a porous substrate; and b) a copolymer covalently attached to the porous substrate, the copolymer comprising a hydrocarbon backbone and a plurality of pendant groups attached to the hydrocarbon backbone, wherein 1) each of a first plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and 2) each of a second plurality of pendant groups comprises: (a) at least one acidic group or salt thereof; and (b) a spacer group that directly links the at least one acidic group or salt thereof to the hydrocarbon backbone by a chain of at least 6 catenated atoms; and wherein the

Abstract: An article, and method of use, wherein the article includes: a substrate; a cationic coating bound to the substrate, wherein the cationic coating includes a guanidinyl-containing polymer that is crosslinked on the substrate; wherein the guanidinyl-containing polymer is of the following Formula (I), wherein: R3 is a H, C1-C12(hetero)alkyl, C5-C12(hetero)aryl, or Polymer; each R4 is independently H, C1-C12(hetero)alkyl, or C5-C12(hetero)aryl; each R5 is H, C1-C12(hetero)alkyl, C5-C12(hetero)aryl, or N(R4)2; Polymer is a residue of an aminopolymer chain; m is 1 or 2; and x is an integer of at least 1; and wherein the guanidinyl-containing polymer is crosslinked with an amine-reactive polyepoxy compound having pendant —OH groups.

Abstract: First articles with covalently attached thiocarbonylthio-containing groups are provided. More specifically, the first articles are a functionalized substrate that contains a solid polymeric substrate with a plurality of thiocarbonylthio-containing groups covalently attached directly to carbon atoms in a polymeric backbone of the solid polymeric substrate. Methods of making the first articles with covalently attached thiocarbonylthio-containing groups are provided. Additionally, second articles and methods of using the first articles to generate second articles with covalently attached polymeric chains are provided.

Abstract: An article that can be used for biomaterial capture comprises (a) a porous substrate; and (b) borne on the porous substrate, a polymer comprising interpolymerized units of at least one monomer consisting of (1) at least one monovalent ethylenically unsaturated group, (2) at least one monovalent ligand functional group selected from acidic groups, basic groups other than guanidino, and salts thereof, and (3) a multivalent spacer group that is directly bonded to the monovalent groups so as to link at least one ethylenically unsaturated group and at least one ligand functional group by a chain of at least six catenated atoms.

Abstract: Described herein is a hydrogel-containing multilayer article and methods of making, said hydrogel-containing multilayer article comprising: (i) a polymeric substrate comprising an abstractable atom; and (ii) a cured aqueous coating composition thereon wherein the coating composition comprises: (a) a hydrophilic monomer comprising a (meth)acrylamide, (meth)acrylate, and combinations thereof: (b) at least 2 wt % of a water-swellable clay; (c) a water-soluble type I photoinitiator; and (d) an acid or salt wherein a water insoluble type II photoinitiator is localized at the interface between the hydrogel coating and the polymeric substrate.

Abstract: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.