Patent number: 4643988
Abstract: The present invention relates to peptides of the formulaA.sub.1 -B.sub.1 -B.sub.2 -C.sub.1 -D-B.sub.3 -B.sub.4 -A.sub.2 -C.sub.2 -B.sub.5 -B.sub.6 -A.sub.3 -C.sub.3 -B.sub.7 -C.sub.4 -A.sub.4 -B.sub.8 -B.sub.9wherein:A.sub.1, A.sub.2, A.sub.3 and A.sub.4 are independently aspartic acid or glutamic acid, or homologues or analogues thereof;B.sub.1, B.sub.2, B.sub.3, B.sub.4, B.sub.5, B.sub.6, B.sub.7, B.sub.8 and B.sub.9 are independently tryptophan, phenylalanine, leucine, alanine, tyrosine, isoleucine, valine or .alpha.-naphtylalanine, or homologues or analogues thereof; C.sub.1, C.sub.2, C.sub.3, and C.sub.4 are independently lysine or arginine, or homologues or analogues thereof, and D is serine, threonine, alanine, glycine, or histidine; provided that, when A.sub.1 and A.sub.2 are aspartic acid, A.sub.3 and A.sub.4 are glutamic acid, B.sub.2 and B.sub.7 are leucine, B.sub.3 and B.sub.9 are phenylalanine, B.sub.4 is tyrosine, B.sub.5 is valine, and C.sub.1, C.sub.2, C.sub.3 and C.sub.4 are lysine, and B.
Type:
Grant
Filed:
May 15, 1984
Date of Patent:
February 17, 1987
Assignee:
Research Corporation
Inventors:
Jere P. Segrest, Gattadahalli M. Anantharamaiah