Abstract: A therapeutic device for extended release drug delivery including a refillable reservoir configured to receive a therapeutic agent and having an outlet for delivery of the therapeutic agent to a patient from the reservoir over an extended period. A porous structure is coupled near the outlet of the reservoir, the porous structure formed of sintered material. A barrier layer is coupled to the reservoir on or adjacent a surface of the porous structure such that the therapeutic agent passes through both the porous structure and the barrier layer upon delivery from the reservoir through the outlet. The porous structure is tuned to deliver the therapeutic agent at a diffusion rate and the barrier layer is adapted to block passage of particles having an average particle size within an average particle size range that is outside an average particle size range blocked by the porous structure. Related methods and systems are provided.

Abstract: Wearable devices for spinal deformities, including a wearable brace configured to be worn about a patient's torso, at least one inflation bladder carried directly or indirectly by an inner surface of the brace, and positioned such that inflation of the bladder with a fluid applies a pressure to generate a force on the patient at a targeted location, at least one force sensor carried directly or indirectly by a surface of the brace, to measure the force independent of the bladder, and the force sensor adapted to output a signal indicative of a force applied on the sensor.