Patents by Inventor Jeremy C. Hwang

Jeremy C. Hwang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS THAT INHIBIT NFkB AND BACE1 ACTIVITY
    Publication number: 20140275165
    Abstract: The present invention relates to compounds with activity as BACE1 and NF?B modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds.
    Type: Application
    Filed: March 24, 2014
    Publication date: September 18, 2014
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Donald W. Landry, Tae-Wan Kim, Shi-Xian Deng, Gangli Gong, Jeremy C. Hwang, Yuli Xie, Yidong Liu, Kirsten Alison Rinderspacher
  • METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING sAPPbeta
    Publication number: 20120214186
    Abstract: The present invention provides methods (assays) for detecting and/or quantifying sAPP?, a secreted ?-secretase (BACE1) cleavage fragment of the ?-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPP? and detecting the presence of the antibody. Also provided are compositions, including antibodies that selectively bind to the BACE1 cleavage site of sAPP?. Kits containing such compositions are also provided. Methods of diagnosing a neurodegenerative disease, such as AD, using the methods and compositions of the present invention are further provided. Methods for identifying BACE1 modulators, candidate compounds that are BACE1 modulators, and methods for treating, preventing or ameliorating neurodegenerative disease, such as AD, using such compounds or pharmaceutical compositions containing such compounds are also provided.
    Type: Application
    Filed: February 13, 2012
    Publication date: August 23, 2012
    Inventors: Tae-Wan Kim, Jeremy C. Hwang
  • COMPOUNDS THAT INHIBIT NFKB AND BACE1 ACTIVITY
    Publication number: 20120064099
    Abstract: The present invention relates to compounds with activity as BACE1 and NF?B modulators, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease. The present invention is also directed to the treatment of diseases related to dysfunction of cell proliferation, the immune system and/or inflammation using such compounds or pharmaceutical compositions containing such candidate compounds.
    Type: Application
    Filed: April 26, 2011
    Publication date: March 15, 2012
    Applicant: The Trustees of Columbia University in The City of New York
    Inventors: Donald W. Landry, Tae-Wan Kim, Shi Xian Deng, Gangli Gong, Jeremy C. Hwang, Yuli Xie, Yidong Liu, K. Alison Rinderspacher
  • Compounds that Inhibit Production of sAPPB and AB and Uses Thereof
    Publication number: 20110071124
    Abstract: The present invention relates to compounds with activity as inhibitors of sAPP? and A? production, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as Alzheimer's disease and pharmaceutical compositions containing such candidate compounds.
    Type: Application
    Filed: August 18, 2010
    Publication date: March 24, 2011
    Applicant: The Trustees of Columbia University in the City of New York
    Inventors: Tae-wan Kim, Donald W. Landry, Jeremy C. Hwang, Shi Xian Deng, Gangli Gong, Yuli Xie, Yidong Liu, Alison Rinderspacher
  • METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING sAPPbeta
    Publication number: 20100221760
    Abstract: The present invention provides methods (assays) for detecting and/or quantifying sAPP?, a secreted ?-secretase (BACE1) cleavage fragment of the ?-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPP? and detecting the presence of the antibody. Also provided are compositions, including antibodies that selectively bind to the BACE1 cleavage site of sAPP?. Kits containing such compositions are also provided. Methods of diagnosing a neurodegenerative disease, such as AD, using the methods and compositions of the present invention are further provided. Methods for identifying BACE1 modulators, candidate compounds that are BACE1 modulators, and methods for treating, preventing or ameliorating neurodegenerative disease, such as AD, using such compounds or pharmaceutical compositions containing such compounds are also provided.
    Type: Application
    Filed: February 23, 2010
    Publication date: September 2, 2010
    Inventors: TAE-WAN KIM, JEREMY C. HWANG
  • METHODS AND COMPOSITIONS FOR DETECTING AND QUANTIFYING SAPPB
    Publication number: 20090162878
    Abstract: The present invention provides methods (assays) for detecting and/or quantifying sAPP?, a secreted ?-secretase (BACE1) cleavage fragment of the ?-amyloid precursor protein (APP), in a biological sample. One such method includes contacting a biological sample with a first antibody that selectively binds to a BACE1 cleavage site on sAPP? and detecting the presence of the antibody. Also provided are compositions, including antibodies that selectively bind to the BACE1 cleavage site of sAPP?. Kits containing such compositions are also provided. Methods of diagnosing a neurodegenerative disease, such as AD, using the methods and compositions of the present invention are further provided. Methods for identifying BACE1 modulators, candidate compounds that are BACE1 modulators, and methods for treating, preventing or ameliorating neurodegenerative disease, such as AD, using such compounds or pharmaceutical compositions containing such compounds are also provided.
    Type: Application
    Filed: January 13, 2009
    Publication date: June 25, 2009
    Inventors: Tae-wan Kim, Jeremy C. Hwang