Patents by Inventor Jeremy D. PETTIGREW

Jeremy D. PETTIGREW has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20240132449
    Abstract: The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating PARP1 activity and may be used in the treatment of disorders in which PARP1 activity is implicated, such as cancer.
    Type: Application
    Filed: August 29, 2023
    Publication date: April 25, 2024
    Inventors: Jayakanth KANKANALA, Jeremy D. PETTIGREW, Jiyun CHEN, Son Minh PHAM
  • HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20240132522
    Abstract: The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating PARP1 activity and may be used in the treatment of disorders in which PARP1 activity is implicated, such as cancer.
    Type: Application
    Filed: August 29, 2023
    Publication date: April 25, 2024
    Inventors: Jayakanth KANKANALA, Jeremy D. PETTIGREW, Aurelia CONTE, Jiyun CHEN, Son Minh PHAM
  • INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20230391790
    Abstract: Compounds of formula (I): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: August 21, 2023
    Publication date: December 7, 2023
    Applicant: TARO PHARMACEUTICALS INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Karthikeyan IYANAR
  • Anti-cancer nuclear hormone receptor-targeting compounds
    Patent number: 11826430
    Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.
    Type: Grant
    Filed: May 13, 2020
    Date of Patent: November 28, 2023
    Assignee: NUVATION BIO INC.
    Inventors: David Hung, Son Minh Pham, Sarvajit Chakravarty, Jiyun Chen, Jayakanth Kankanala, Jeremy D. Pettigrew, Anup Barde, Anjan Kumar Nayak
  • HETEROCYCLIC COMPOUNDS AS BET INHIBITORS
    Publication number: 20230339964
    Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.
    Type: Application
    Filed: January 9, 2023
    Publication date: October 26, 2023
    Inventors: Son Minh PHAM, Sarvajit Chakravarty, Jayakanth Kankanaka, Jiyun Chen, Chris P. Miller, Jeremy D. Pettigrew, Anjan Kumar Nayak, Anup Barde
  • Indene derivatives useful in treating pain and inflammation
    Patent number: 11773108
    Abstract: Compounds of formula (1): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Grant
    Filed: May 23, 2022
    Date of Patent: October 3, 2023
    Assignee: Taro Pharmaceuticals Inc.
    Inventors: Curtis Harwig, Jeremy D. Pettigrew, Jennifer Cross, Jeyaprakashnarayanan Seenisamy, Mahesh Narayan Keregadde, Karthikeyan Iyanar
  • HEXADECAHYDRO-1H-CYCLOPENTA[A]PHENANTHRENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20230203089
    Abstract: Wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: February 17, 2023
    Publication date: June 29, 2023
    Applicant: TARO PHARMACEUTICALS INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Samir Satish KHER, Karthikeyan IYANAR
  • HETEROCYCLIC COMPOUNDS AS BET INHIBITORS
    Publication number: 20230174545
    Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.
    Type: Application
    Filed: April 28, 2021
    Publication date: June 8, 2023
    Inventors: Son Minh PHAM, Jayakanth KANKANALA, Chris P. MILLER, Jeremy D. PETTIGREW
  • Heterocyclic compounds as BET inhibitors
    Patent number: 11584756
    Abstract: Novel bromodomain and extraterminal domain (BET) inhibitors and to therapeutic methods of treating conditions and diseases using these novel BET inhibitors are provided.
    Type: Grant
    Filed: July 1, 2020
    Date of Patent: February 21, 2023
    Assignee: NUVATION BIO INC.
    Inventors: Son Minh Pham, Sarvajit Chakravarty, Jayakanth Kankanala, Jiyun Chen, Chris P. Miller, Jeremy D. Pettigrew, Anjan Kumar Nayak, Anup Barde
  • HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20230026856
    Abstract: The present disclosure relates to inhibitors of one or more isoforms of RAS, such as inhibitors of one or more of KRAS, HRAS and NRAS, or mutants thereof, such as G12D, G12V, G13D or G12C mutants thereof. Therapeutic methods of treating conditions and diseases using these inhibitors are also provided.
    Type: Application
    Filed: June 4, 2021
    Publication date: January 26, 2023
    Inventors: Jayakanth KANKANALA, Jeremy D. PETTIGREW, Son Minh PHAM, Sarvajit CHAKRAVARTY, Jiyun CHEN
  • HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20230023009
    Abstract: The present disclosure relates to inhibitors of one or more isoforms of RAS, such as inhibitors of one or more of KRAS, HRAS and NRAS, or mutants thereof, such as G12D, G12V, G13D or G12C mutants thereof. Therapeutic methods of treating conditions and diseases using these inhibitors are also provided.
    Type: Application
    Filed: June 4, 2021
    Publication date: January 26, 2023
    Inventors: Jayakanth KANKANALA, Jeremy D. PETTIGREW, Son Minh PHAM, Sarvajit CHAKRAVARTY, Jiyun CHEN
  • INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20230002366
    Abstract: Compounds of formula (I) wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: August 4, 2022
    Publication date: January 5, 2023
    Applicant: TARO PHARMACEUTICALS INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Samir Satish KHER
  • INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20220306645
    Abstract: Compounds of formula (1): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: May 23, 2022
    Publication date: September 29, 2022
    Applicant: TARO PHARMACEUTICALS INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Karthikeyan IYANAR
  • HETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS
    Publication number: 20220273659
    Abstract: Heterocyclic compounds as CDK4 or CDK6 or other CDK inhibitors are provided. The compounds may find use as therapeutic agents for the treatment of diseases and may find particular use in oncology.
    Type: Application
    Filed: July 1, 2020
    Publication date: September 1, 2022
    Inventors: Son Minh PHAM, Sarvajit CHAKRAVARTY, Jayakanth KANKANALA, Brahmam PUJALA, Amit SHETE, Mukesh GANGAR, Bhawana BHATT, Chris P. MILLER, Jeremy D. PETTIGREW
  • Indene derivatives useful in treating pain and inflammation
    Patent number: 11420962
    Abstract: Compounds of formula (I) wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: August 23, 2022
    Assignee: TARO PHARMACEUTICALS INC.
    Inventors: Curtis Harwig, Jeremy D. Pettigrew, Jennifer Cross, Jeyaprakashnarayanan Seenisamy, Mahesh Narayan Keregadde, Samir Satish Kher
  • Indene derivatives useful in treating pain and inflammation
    Patent number: 11352367
    Abstract: Compounds of formula (I): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: June 7, 2022
    Assignee: TARO PHARMACEUTICALS INC.
    Inventors: Curtis Harwig, Jeremy D. Pettigrew, Jennifer Cross, Jeyaprakashnarayanan Seenisamy, Mahesh Narayan Keregadde, Karthikeyan Iyanar
  • Diarylhydantoin compounds and methods of use thereof
    Patent number: 11292782
    Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: April 5, 2022
    Assignee: Nuvation Bio Inc.
    Inventors: Sarvajit Chakravarty, Son Minh Pham, Jiyun Chen, Jayakanth Kankanala, Jeremy D. Pettigrew, Anjan Kumar Nayak, Anup Barde, Brahmam Pujala
  • Pyrrole and pyrazole compounds and methods of use thereof
    Patent number: 11034669
    Abstract: The disclosure relates to anti-cancer compounds derived from nuclear steroid receptor binders, to products containing the same, as well as to methods of their use and preparation.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: June 15, 2021
    Assignee: Nuvation Bio Inc.
    Inventors: Sarvajit Chakravarty, Son Minh Pham, Jiyun Chen, Jayakanth Kankanala, Jeremy D. Pettigrew, Anjan Kumar Nayak, Anup Barde, Brahmam Pujala
  • INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20210155615
    Abstract: Compounds of formula (I) wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: April 5, 2019
    Publication date: May 27, 2021
    Applicant: AQUINOX PHARMACEUTICALS (CANADA) INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Samir Satish KHER
  • INDENE DERIVATIVES USEFUL IN TREATING PAIN AND INFLAMMATION
    Publication number: 20210032264
    Abstract: Compounds of formula (I): wherein, R1, R2, R3, R4a, R4b and R5 are described herein, or a stereoisomer, enantiomer or tautomer thereof or mixtures thereof, or a pharmaceutically acceptable salt or solvate thereof, are described herein, as well as other compounds. These compounds are useful in treating inflammation and/or pain. Compositions comprising a compound of the invention are also disclosed, as are methods of using the compounds to treat inflammation and/or pain.
    Type: Application
    Filed: April 5, 2019
    Publication date: February 4, 2021
    Applicant: AQUINOX PHARMACEUTICALS (CANADA) INC.
    Inventors: Curtis HARWIG, Jeremy D. PETTIGREW, Jennifer CROSS, Jeyaprakashnarayanan SEENISAMY, Mahesh Narayan KEREGADDE, Karthikeyan IYANAR