Abstract: A series of 5-6 fused ring bicyclic heteroaromatic derivatives, based in particular on the 6-oxo-6,7-dihydrothieno[2,3->b]pyridine ring system, being inhibitors of p38 kinase, are accordingly of use in medicine, for example in the treatment and/or prevention of immune or inflammatory disorders.

Abstract: A method and apparatus for securely displaying and communicating trusted and untrusted internet content via a web browser is described. In a preferred embodiment, the invention is an electronic marketplace system in which auction-related content is displayed in one window of a customer's web browser while item-related content is displayed in a second window of the customer's web browser, such that the auction-related content and the item-related content are substantially prevented from substantially interacting. The invention further provides a method and apparatus for communicating predetermined information between multiple documents opened in multiple web browser windows, where the documents are served from multiple domains.

Abstract: Bicyclic heteroaromatic derivatives of formula (1) are described: F (1) where: the dashed line joining A and C(Ra) is present and represents a bond and A is a —N? atom or a —C(Rb)? group, or the dashed line is absent and A is a —N(Rb)—, or —C(Rb)(Rc)—group; X is an —O—, —S— or substituted nitrogen atom or a —S(O)—, —S(O2)— or —NH-group; Y is a nitrogen or substituted carbon atom or a —CH? group; n is zero or the integer 1; Alk1 is an optionally substituted aliphatic or heteroaliphatic chain L1 is a covalent bond or a linker atom or group; Cy1 is a hydrogen atom or an optionally substituted cycloaliphatic, polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; Ar is an optionally substituted aromatic or heteroaromatic group; and the remaining substituents are defined in the specification. The compounds are potent and selective inhibitors of p38 kinase and are of use in the prophylaxis and treatment of immune or inflammatory disorders.

Abstract: The present invention provides a data processing apparatus and method of controlling access to a shared resource. The data processing apparatus has a plurality of processors operable to perform respective data processing operations requiring access to the shared resource, and a path is provided interconnecting the plurality of processors. An access control mechanism is operable to control access to the shared resource by the plurality of processors, each processor being operable to enter a power saving mode if access to the shared resource is required but the access control mechanism is preventing access to the shared resource by that processor. Further, each processor is operable, when that processor has access to the shared resource, to issue a notification on the path when access to the shared resource is no longer required by that processor. A processor in the power saving mode is arranged, upon receipt of that notification, to exit the power saving mode and to seek access to the shared resource.

Abstract: A method and system to display a pop-up window when a user leaves a website are disclosed. A user accesses a website with a web browser. When a web page from the website is loaded into the user's browser, a client-side variable is set to a particular value, such as the current time. When the web page from the website is unloaded from the browser, a hidden pop-up window is loaded. The hidden pop-up window is programmed to sleep and then check the value of the client-side variable. A change in the value of the client-side variable indicates a new web page from the same web server has been loaded into the web browser and the user has not left the website. However, if a web page from a different web server is loaded into the browser, then the value of the client-side variable remains unchanged. Consequently, when the hidden pop-up window awakes and checks the value of the client-side variable, the pop-up window can determine whether the user has left the original website.

Abstract: Pyrimidines of formla (1) are described: wherein R1 is a —XR6 group; R2 and R3 which may be the same or different is each a hydrogen or halogen atom or a group selected from an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, —OH, —OR10 [where R10 is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group) —SH, —NO2, —CN, —SR10, —COR10, S(O)R10, —SO2R8, —SO2N(R8)(R9), —CO2R8, —CON(R8)(R9), —CSN(R8)(R9), —NH2 or substituted amino group; R4 is a X1R11 group where X1 is a covalent bond or a —C(R12)(R13)— [where each of R12 and R13 is a hydrogen or halogen atom or a hydroxyl, alkyl or haloalkyl group] or —C(O)— group and R11 is an optionally substituted phenyl, thienyl, thiazolyl or indolyl group; R5 is a halogen atom or an alkynyl group; and the salts, solvates, hydrates and N-oxides thereof.

Abstract: Compounds of formula (1) are described in which Ra and Rb is each independently a hydrogen atom or a group Rc, or Ra and Rb together form an oxo (?O) or thio (?S) group; X is a N atom or an optionally substituted CH group: Y is a —O— or —S— atom or —SO— or —SO2— group or an optionally substituted —CH2— or —NH— group with the proviso that when Ra and Rb together form an oxo (?O) or thio (?S) group Y is an optionally substituted —CH2— or —NH-group; L1 is a covalent bond or a linker atom or group; p is zero or the integer 1; Alk1 is an optionally substituted C1-10aliphatic or C1-10heteroaliphatic chain; n is zero the integer 1, 2 or 3 with the proviso that when n is zero Y is an optionally substituted —CH2— group: Ar is an optionally substituted C6-12aromatic or C1-9heteroaromatic group; m is zero or the integer 1, 2 or 3; q is zero or the integer 1 or 2; R1, Rc and Rd are hydrogen atoms or the substituents described in the patent specification; and the salts, solvates, hydrates and N-oxides thereof.

Abstract: An occlusion for use in a peristaltic pump includes independently movable occlusion fingers. The fingers are integrally formed as a single unitary body.

Abstract: A peristaltic pump device and method includes at least one roller of a rotor rotatable with respect to an occlusion with a substantially constant radius. A depression is formed in the occlusion and extends beyond the substantially constant radius of the occlusion.

Abstract: A pump having a rotary portion which compels the movement of a fluid by peristaltic compression of resilient tubing containing the fluid includes a tube component having a plurality of adjacent resilient tubes, with a web interconnecting the adjacent resilient tubes. The web may be offset from the centerline of the tubes so as not to degrade the compressibility of the tubes.