Abstract: The present invention relates to methods of delaying progression to end stage renal disease (ESRD) in patients comprising administration of 1-(2-ethoxyethyl)-5-(ethyl(methyl)amino)-7-((4-methylpyridin-2-yl)amino)-N-(methylsulfonyl)-1H-pyrazolo[4,3-d]pyrimidine-3-carboxamide. The present invention also includes administration of pharmaceutical compositions for delaying progression to ESRD.

Abstract: The present invention relates to methods of delaying progression to end stage renal disease (ESRD) in patients comprising administration of 1-(2-ethoxyethyl)-5-(ethyl(methyl)amino)-7-((4-methyl-pyridin-2-yl)amino)-N-(methylsulfonyl)-1H-pyrazolo[4,3-d]pyrimidine-3-carboxamide. The present invention also includes administration of pharmaceutical compositions for delaying progression to ESRD. 1-(2-ethoxyethyl)-5-(ethyl(methyl)amino)-7-((4-methyl-pyridin-2-yl)amino)-N-(methylsulfonyl)-1H-pyrazolo[4,3-d]pyrimidine-3-carboxamide.

Abstract: A mechanized agriculture management apparatus includes a chassis supporting a first manually independently operable boom and a second manually independently operable boom. The booms extend from either side of the chassis and support interchangeable accessories. The accessories may be dedicated to perform various growth control operations such as shoot thinning, fruit thinning, vertical impacting, lateral impacting, hedging, trunk cleaning, shoot positioning, deleafing, pruning and/or wire lifting, as well as other operations and are interchangeable so that one mechanized apparatus may be utilized for the various operations.