Abstract: The stirring device, in particular for a fluid-mixing bioreactor, comprises a drive shaft including a rod, an agitating element and a sleeve of tubular shape. The sleeve forms a coupling sleeve receiving the shaft therethrough and is directly rotationally coupled to the rod. The agitating element, which has a hub with an annular side wall delimiting an inner space and an impeller assembly comprising blades, is indirectly rotationally coupled to the rod via the sleeve that is engaged in the inner space. One of an inner surface of the wall and an outer surface of the sleeve is a guiding surface with progressively reduced cross section. Axial movement between the hub and the sleeve is prevented in a locked configuration of a sleeve fastening arrangement. Hub-sleeve contact areas can be axially distributed.

Abstract: A biopharmaceutical liquid reservoir, includes a bag forming an inner storage space for storing a biopharmaceutical liquid, a mechanical member located at a wall of the bag, having: a stationary set of parts that is stationary with respect to the wall of the bag, a rotating set of parts rotating about an axis of rotation with respect to the stationary set, a bearing located between the two sets and, inside the bag, a communication passage: separating the bearing from the inner storage space, including one or more changes of direction, being formed by a portion of the parts of the rotating set located opposite a portion of the parts of the stationary set.

Abstract: A fluid-connection device capable of and intended for connecting a flexible pipe to a flexible or rigid pipe or enclosure in a biopharmaceutical assembly such as to provide fluid communication between two fluid spaces, including a first connector in fluid communication with the first fluid space, a second connector in fluid communication with the second fluid space, the first connector and the second connector optionally being coupled together in a coupling position, the first connector including a tubular nozzle which can be inserted in one end of the pipe, a pipe clamp being arranged around the end of the tube in order to clamp the pipe onto the tubular nozzle of the first connector, the second connector including protection elements which, in the coupling position, are positioned radially at least partially opposite the pipe clamp, whereby the pipe clamp cannot come into direct contact with external elements.

Abstract: A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.

Abstract: A fluid connection set includes a connector (1), a flexible hose (2), and a crimping collar (5) for fixing the front end of the flexible hose to the connector, the connector including a connector body (10), a tubular nozzle (3), the tubular nozzle including retaining radial projections (31) of the hose as well as a clamping area (30) of the hose, and a temporary accommodation space (4), arranged between the tubular nozzle (3) and the connector body (10), for housing the collar during the operation of inserting the flexible tube, after which the collar is moved with respect to the clamping area and then crimped.

Abstract: Disclosed is a fluid-connection device for connecting a first wall defining a first fluid space, in the form of a flexible pipe, to a second wall defining a second fluid space, in the form of a flexible or rigid disposable pipe or enclosure, in a biopharmaceutical assembly, including a first connector in fluid communication with the first space, the first connector including a tubular nozzle for receiving the pipe by insertion along the axis A, a pipe clamp arranged around the end of the pipe in order to clamp the pipe onto the tubular nozzle of the first connector, a protective cover forming a separate part, capable of being snap-fit in an operative position in which the cover is at least partially surrounding the first connector and the pipe clamp thereof, by way of which the pipe clamp cannot come into direct contact with external elements.

Abstract: Disclosed is a fluid-connection device for connecting a first wall defining a first fluid space, for example a flexible pipe, to a second wall defining a second fluid space, in the form of a flexible pipe or enclosure, including a first male connector, the first connector including a seal and a snap-fitting collar, the seal extending radially prior to coupling from the axis until a first radial distance R1, a second female connector capable of receiving the first connector, the second connector including at least one flexible tab with one end against which the locking collar abuts in coupling position, in order to prevent retraction from the coupling position, the flexible tab being defined relative to the axis between a second radial distance R2 and a third radial distance R3, which is greater than the second radial distance R2, wherein R2>R1.

Abstract: Female connector for accepting a male connector having a retaining external annular rim, a slot including two parallel lateral grooves and the slot opening at least at one of its ends forming a mouth of the housing, the female connector including a locking slide distinct from the body, movable between a locking position and an unlocking position, the locking slide including a locking plate and an actuating knob formed integrally with the plate, with a retaining portion belonging to the locking plate to come into abutment against the retaining outer annular rim, the locking slide including at least one flexible tab formed integrally, returning the slide toward the first position, the flexible tab pressing on each side of the mouth in the axial direction X so that the return force is balanced about X and creates no torque that could have a tendency to cause the locking plate to jam.

Abstract: A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.

Abstract: A method for assembling a mixer-container intended for receiving a biopharmaceutical fluid includes providing a container with a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to a wall of the container, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container; and a drive motor located outside the container, the first bearing of the container is placed so as to be spaced apart from the motor, and the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.

Abstract: Fluid-connection device for connecting a flexible pipe defining a first fluid space to a second flexible pipe or a flexible fluid enclosure in a biopharmaceutical assembly, includes a first connector and a second connector equivalent thereto, the first connector and second connector adapted to be coupled together in a genderless manner, by an insertion movement that is essentially an axial translation, into a relative coupling position, which defines a mating plane, each of the connectors including, in an alternating manner along the circumferential direction, N flexible snap-fitting tabs and N stop surfaces, the flexible snap-fitting tabs projecting axially forwards relative to the mating plane, and the stop surfaces being set back from the mating plane so that, in the coupling position, the snap-fitting tabs of one connector clip into place on the stop surfaces of the other connector, such that the resulting position is locked by the snap-fitting tabs.

Abstract: A coupling device for sealingly coupling a first wall defining a flexible pipe (11) to a tubular nozzle (9) of a connector (1) in a biopharmaceutical assembly, the coupling device including the connector (1) including the tubular nozzle (9), on which one end of the pipe can be inserted along an axis A, a plurality of flexible tabs (3) extending from an intermediate area (7) of the coupling body toward the free end (1a) of the nozzle, an abutment clamp (16), a connection interface (6), a separate ring (2), axially movable between an inoperative position and an operative position, for covering the flexible tabs (3) such as to push same radially inward in order to press the pipe onto the nozzle in the operative position, the tabs extending substantially parallel to the axis (A) when the ring (2) is in the operative position.

Abstract: A modular fluid connection assembly includes a female connector (1) for fluid connection, provided to receive a male connector (2) having an external annular retaining rim (24), the female connector including a body (10) with an axial bore X, and a slide forming a transverse housing (4), the housing (4) including two parallel lateral grooves (41, 42) and the housing opening at at least one of its ends (40) along the direction of the slide Z, the assembly including a non-unlocking locking element (3), in the form of a deformable locking ring (3), the assembly including an unlocking locking element (5), in the form of a locking slider (5), in which the female connector is configured to receive equally either a non-unlocking element, or an unlocking element.

Abstract: A female connector (1) configured to receive a male connector (2), having an annular exterior retaining rim (24), the female connector including a body (10), and a transverse slide (4) forming a housing, the housing (4) including two lateral grooves (41,42), the female connector including a separate deformable locking ring (3) capable of being inserted in the housing and of locking the male connector in the coupling position, the locking ring including two first concave arched portions (31), as viewed from the axis, and two second arched portions (32), with inverse curvature, i.e. convex when viewed from the axis, the second arched portions being capable of flexing towards the exterior during insertion of the male connector and capable of abutting on the external annular retaining rim and preventing withdrawal of the male connector, whereby after locking of the male connector in the female connector a definitive locking is obtained.

Abstract: Disclosed is a method for assembling a mixer-container intended for receiving a biopharmaceutical fluid in which: a container is provided, the container including: a mixing device including at least one shaft having an adjustable length, and at least one first bearing attached to the wall, the shaft extending at least into the inner space from the first bearing; a rigid outer device that compresses the container is provided; a drive motor located outside the container is provided; the first bearing of the container is placed so as to be spaced apart from the motor; the length of the shaft is adjusted along the main axis by arranging the shaft opposite the motor to enable the motor to rotate the shaft.

Abstract: A fluid connection set includes a connector (1), a flexible hose (2), and a crimping collar (5) for fixing the front end of the flexible hose to the connector, the connector including a connector body (10), a tubular nozzle (3), the tubular nozzle including retaining radial projections (31) of the hose as well as a clamping area (30) of the hose, and a temporary accommodation space (4), arranged between the tubular nozzle (3) and the connector body (10), for housing the collar during the operation of inserting the flexible tube, after which the collar is moved with respect to the clamping area and then crimped.

Abstract: A female connector (1) configured to receive a male connector (2), having an annular exterior retaining rim (24), the female connector including a body (10), and a transverse slide (4) forming a housing, the housing (4) including two lateral grooves (41,42), the female connector including a separate deformable locking ring (3) capable of being inserted in the housing and of locking the male connector in the coupling position, the locking ring including two first concave arched portions (31), as viewed from the axis, and two second arched portions (32), with inverse curvature, i.e. convex when viewed from the axis, the second arched portions being capable of flexing towards the exterior during insertion of the male connector and capable of abutting on the external annular retaining rim and preventing withdrawal of the male connector, whereby after locking of the male connector in the female connector a definitive locking is obtained.

Abstract: Female connector for accepting a male connector having a retaining external annular rim, a slot including two parallel lateral grooves and the slot opening at least at one of its ends forming a mouth of the housing, the female connector including a locking slide distinct from the body, movable between a locking position and an unlocking position, the locking slide including a locking plate and an actuating knob formed integrally with the plate, with a retaining portion belonging to the locking plate to come into abutment against the retaining outer annular rim, the locking slide including at least one flexible tab formed integrally, returning the slide toward the first position, the flexible tab pressing on each side of the mouth in the axial direction X so that the return force is balanced about X and creates no torque that could have a tendency to cause the locking plate to jam.

Abstract: A modular fluid connection assembly includes a female connector (1) for fluid connection, provided to receive a male connector (2) having an external annular retaining rim (24), the female connector including a body (10) with an axial bore X, and a slide forming a transverse housing (4), the housing (4) including two parallel lateral grooves (41, 42) and the housing opening at at least one of its ends (40) along the direction of the slide Z, the assembly including a non-unlocking locking element (3), in the form of a deformable locking ring (3), the assembly including an unlocking locking element (5), in the form of a locking slider (5), in which the female connector is configured to receive equally either a non-unlocking element, or an unlocking element.

Abstract: Disclosed is a fluid-connection device for connecting a first wall defining a first fluid space, for example a flexible pipe, to a second wall defining a second fluid space, in the form of a flexible pipe or enclosure, including a first male connector, the first connector including a seal and a snap-fitting collar, the seal extending radially prior to coupling from the axis until a first radial distance R1, a second female connector capable of receiving the first connector, the second connector including at least one flexible tab with one end against which the locking collar abuts in coupling position, in order to prevent retraction from the coupling position, the flexible tab being defined relative to the axis between a second radial distance R2 and a third radial distance R3, which is greater than the second radial distance R2, wherein R2>R1.