Patents by Inventor Jeremy Green

Jeremy Green has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Publication number: 20040023963
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: May 14, 2003
    Publication date: February 5, 2004
    Inventors: Jingrong Cao, Jeremy Green, Young-Choon Moon, Jian Wang, Mark Ledeboer, Edmund Harrington, Huai Gao
  • Inhibitors of GSK-3 and uses thereof
    Publication number: 20040024040
    Abstract: The present invention relates to compounds of formula I that are useful as GSK-3 inhibitors. The invention also relates to methods of using compounds of formula I or pharmaceutical compositions comprising compounds of formula I to inhibit GSK-3 activity. The invention further provides methods of utilizing these compounds and pharmaceutical compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. The invention also relates to methods for inhibiting Aurora-2 activity and for treating or preventing Aurora-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I. The invention also relates to methods for inhibiting cyclin-dependent kinase-2 activity and for treating or preventing inhibiting cyclin-dependent kinase-2-mediated diseases using compounds of formula I or pharmaceutical compositions comprising compounds of formula I.
    Type: Application
    Filed: August 2, 2002
    Publication date: February 5, 2004
    Inventors: Jeremy Green, Michael J. Arnost, Albert Pierce
  • Protein kinase inhibitors and uses thereof
    Publication number: 20040009996
    Abstract: Described herein are benzisoxazole compounds of formula I: 1
    Type: Application
    Filed: June 14, 2002
    Publication date: January 15, 2004
    Inventors: Young-Choon Moon, Jeremy Green, Robert Davies, Deborah Choquette, Albert Pierce, Mark Ledeboer
  • Pyrazole compositions useful as inhibitors of ERK
    Publication number: 20030225151
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: January 2, 2003
    Publication date: December 4, 2003
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang
  • Pyrazole compounds useful as protein kinase inhibitors
    Patent number: 6653300
    Abstract: This invention describes novel pyrazole compounds of formula I′: wherein Q′ is —O—, —C(R6′)2—, 1,2-cyclopropanediyl, 1,2-cyclobutanediyl, or 1,3-cyclopropanediyl, and R1 is T-Ring D, wherein Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rx and Ry are independently selected from T—R3 or L—Z—R3, or Rx and Ry are taken together with their intervening atoms to form a fused, unsaturated or partially unsaturated, 5-7 membered ring having 0-3 heteroatoms; and R2 and R2′ are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of Aurora-2 and GSK-3, for treating diseases such as cancer, diabetes and Alzheimer's disease.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: November 25, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: David Bebbington, Jean-Damien Charrier, Julian Golec, Jeremy Green, David Kay, Ronald Knegtel, Andrew Miller, Ronald Tomlison, Pan Li
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Patent number: 6642227
    Abstract: The present invention provides compounds of formula I: or a pharmaceutically acceptable derivative o thereof, wherein A, B, Ra, R1, R2, R3, and R4 are as described in the specification. These compounds are inhibitors of protein kinase, particularly inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli; Lck and Src kinase. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: November 4, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jingrong Cao, Jeremy Green, Young-Choon Moon, Jian Wang, Mark Ledeboer, Edmund Harrington, Huai Gao
  • Inhibitors of c-Jun N-terminal kinases (JNK)
    Publication number: 20030153560
    Abstract: The present invention relates to inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Application
    Filed: October 23, 2001
    Publication date: August 14, 2003
    Inventors: Francesco G. Salituro, Guy W. Bemis, Susanne Wilke, Jeremy Green, Jingrong Cao, Huai Gao, Edmund Martin Harrington
  • Inhibitors of c-Jun N terminal kinases (JNK) and other protein kinases
    Publication number: 20030149051
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: February 12, 2002
    Publication date: August 7, 2003
    Inventors: Jeremy Green, Guy Bemis, Anne-Laure Grillot, Mark Ledeboer, Francesco G. Salituro, Edmund Harrington, Huai Gao, Christopher Baker, Jingrong Cao, Michael Hale
  • Pyrazole compositions useful as inhibitors of ERK
    Patent number: 6593357
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: August 22, 2002
    Date of Patent: July 15, 2003
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Jeremy Green, Jingrong Cao, Michael Hale, Christopher Baker, Francois Maltais, James Janetka, Michael Mullican, Guy Bemis, Xiaoling Xie, Judith Straub, Qing Tang
  • Inhibitors of GSK-3 and crystal structures of GSK-3 protein and protein complexes
    Publication number: 20030125332
    Abstract: The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various disorders, such as diabetes and Alzheimer's disease. In addition, the invention relates to molecules or molecular complexes which comprise binding pockets of GSK-3&bgr; or its homologues. The invention relates to a computer comprising a data storage medium encoded with the structure coordinates of such binding pockets. The invention also relates to methods of using the structure coordinates to solve the structure of homologous proteins or protein complexes. The invention relates to methods of using the structure coordinates to screen for and design compounds that bind to GSK-3&bgr; protein or homologues thereof. The invention also relates to crystallizable compositions and crystals comprising GSK-3&bgr; protein or GSK-3&bgr; protein complexes.
    Type: Application
    Filed: April 29, 2002
    Publication date: July 3, 2003
    Inventors: Ernst ter Haar, Lovorka Swenson, Jeremy Green, Michael J. Arnost
  • Inhibitors of c-Jun N-terminal kinases (JNK)
    Publication number: 20030100549
    Abstract: The present invention relates to inhibitors of JNK, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Application
    Filed: December 3, 2001
    Publication date: May 29, 2003
    Inventors: Francesco Salituro, Guy Bemis, Jeremy Green, Jasna Fejzo, Xiaoling Xie
  • Inhibitors of p38
    Publication number: 20030096817
    Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Application
    Filed: May 10, 2002
    Publication date: May 22, 2003
    Inventors: Jeremy Green, Scott L. Harbeson, John E. Cochran
  • Inhibitors of c-Jun N-terminal kinases (JNK) and other protein kinases
    Publication number: 20030096816
    Abstract: The present invention provides compounds of formula I: 1
    Type: Application
    Filed: April 10, 2002
    Publication date: May 22, 2003
    Inventors: Jingrong Cao, Jeremy Green, Young-Choon Moon, Jian Wang, Mark Ledeboer, Edmund Harrington, Huai Gao
  • Heterocyclic inhibitors of ERK2 and uses thereof
    Publication number: 20030092714
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: February 8, 2002
    Publication date: May 15, 2003
    Inventors: Jingrong Cao, Jeremy Green, Michael Hale, Francois Maltais, Judy Straub, Qing Tang, Alex Aronov
  • Pyrazole compositions useful as inhibitors of ERK
    Patent number: 6528509
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: where R1-4, Q, and T are described in the specification. The compounds are useful for treating disease states in mammals that are alleviated by a protein kinase inhibitor, particularly diseases such as cancer, inflammatory disorders, restenosis, and cardiovascular disease.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: March 4, 2003
    Assignee: Vertex Pharmacuticals, Incorporated
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang, Robert Mashal
  • Pyrazole compositions useful as inhibitors of ERK
    Publication number: 20030040536
    Abstract: Described herein are compounds that are useful as protein kinase inhibitors having the formula: 1
    Type: Application
    Filed: October 5, 2001
    Publication date: February 27, 2003
    Inventors: Michael Hale, Xiaoling Xie, Jeremy Green, Jingrong Cao, Christopher Baker, Francois Maltais, James Janetka, Guy Bemis, Michael Mullican, Judith Straub, Qing Tang, Robert Mashal
  • Pyrazole compounds useful as protein kinase inhititors
    Publication number: 20030004161
    Abstract: This invention describes novel pyrazole compounds of formula I′: 1
    Type: Application
    Filed: December 19, 2001
    Publication date: January 2, 2003
    Inventors: David Bebbington, Jean-Damien Charrier, Julian Golec, Jeremy Green, David Kay, Ronald Knegtel, Andrew Miller, Ronald Tomlison, Pan Li
  • Inhibitors of p38
    Patent number: 6093742
    Abstract: The present invention relates to inhibitors of p38, a mammalian protein kinase involved in cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders.
    Type: Grant
    Filed: June 27, 1997
    Date of Patent: July 25, 2000
    Assignee: Vertex Pharmaceuticals, Inc.
    Inventors: Francesco Gerald Salituro, Guy W. Bemis, Jeremy Green, James L. Kofron