Patents by Inventor Jeremy J. Mao
Jeremy J. Mao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190117696Abstract: Provided herein are compositions and methods for healing cartilage tissue defects or injury by forming fibrochondrocyte cells or fibrochondrocyte-like cells from recruited progenitor cells, such as mesenchymal stem cells.Type: ApplicationFiled: March 13, 2016Publication date: April 25, 2019Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Chang Hun Lee
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Publication number: 20170112972Abstract: Provided herein are compositions and methods for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells, such as mesenchymal stem cells. One aspect provides a fibrochondrocyte culture medium including CTGF and TGF?3, optionally encapsulated by microspheres having different release profiles. Another aspect provides a method for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells by culturing with CTGF and TGF?3.Type: ApplicationFiled: November 7, 2016Publication date: April 27, 2017Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Chang Hun Lee
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Patent number: 9603899Abstract: Provided is a method of causing a cell to migrate to a scaffold. Also provided is a method of treating a mammal that has a tissue defect. Further provided is a tissue scaffold comprising platelet-derived growth factor (PDGF). Additionally, a method of making a tissue scaffold capable of recruiting a cell is provided.Type: GrantFiled: October 3, 2011Date of Patent: March 28, 2017Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Wenli Zhao
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Patent number: 9597359Abstract: Described is a method of forming a mineralized material by co-culturing epithelial cell, such as ameloblast, and mesenchymal cell, such as osteoblast or odontoblast, in a mineral-stimulating medium. Also described is a matrix seeded with epithelial cells and mesenchymal cells and infused with a mineral-stimulating medium capable of forming a mineralized material in the matrix. Methods of manufacturing such compositions and methods of treating mineralization-related conditions are also described.Type: GrantFiled: October 3, 2011Date of Patent: March 21, 2017Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Mo Chen
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Patent number: 9487754Abstract: Provided herein are compositions and methods for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells, such as mesenchymal stem cells. One aspect provides a fibrochondrocyte culture medium including CTGF and TGF?3, optionally encapsulated by microspheres having different release profiles. Another aspect provides a method for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells by culturing with CTGF and TGF?3.Type: GrantFiled: October 3, 2011Date of Patent: November 8, 2016Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Chang Hun Lee
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Patent number: 9402880Abstract: It has been discovered that that certain growth factors can delay the ossification of a tissue site, such as a cranial suture, via the promotion of fibroblast differentiation and/or inhibition of osteoblast differentiation. Provided herein are methods for treating bone formation conditions or disorders, such as synostotic conditions, or ectopic mineralization conditions, via administration of compositions comprising connective tissue growth factor (CTGF), and optionally other growth factors or fibroblast or progenitor cells, to a tissue site of a subject in need thereof.Type: GrantFiled: March 5, 2013Date of Patent: August 2, 2016Assignee: The Trustees of Columbia University in the City of New YorkInventor: Jeremy J. Mao
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Publication number: 20160120805Abstract: Provided are methods of treating a subject with a composition comprising an exosome or a polypeptide, RNA, or miRNA contained therein or identified or isolated therefrom. Also provided are methods of promoting dentinogenesis, amelogenesis, or osteogenesis. Also provided are compositions comprising an exosome or a polypeptide, RNA, or miRNA contained therein or identified or isolated therefrom.Type: ApplicationFiled: June 5, 2014Publication date: May 5, 2016Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Ying Wan, Nan Jiang, Mo Chen
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Patent number: 9199002Abstract: Provided are hybrid soft tissue constructs comprising a core material, a biomaterial matrix and mammalian cells. Also provided are methods of augmenting or reconstructing a soft tissue of a mammal. Additionally, methods of forming a hybrid soft tissue construct are provided. The use of the above constructs for augmenting or reconstructing a soft tissue of a mammal are further provided. Additionally provided is the use of the above constructs for the manufacture of a medicament for augmenting or reconstructing a soft tissue of a mammal.Type: GrantFiled: May 23, 2008Date of Patent: December 1, 2015Assignee: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Eduardo K. Moioli
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Publication number: 20150335400Abstract: Provided is a mammalian tooth-shaped scaffold including a composition that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a tooth in the mouth of a mammal, where the tooth is absent and a tooth socket is present in the mouth at the position of the absent tooth. The method comprises implanting a scaffold having the shape of the missing tooth into the tooth socket. Additionally, a method of making a tooth scaffold is provided. The method comprises synthesizing a scaffold in the shape of a mammalian tooth and adding at least one composition that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic.Type: ApplicationFiled: March 17, 2015Publication date: November 26, 2015Applicant: The Trustees of Columbia University in the City of New YorkInventor: Jeremy J. Mao
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Patent number: 8979534Abstract: Provided is an acellular mammalian tooth-shaped scaffold including a compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a tooth in the mouth of a mammal, where the tooth is absent and a tooth socket is present in the mouth at the position of the absent tooth. The method includes implanting an acellular scaffold having the shape of the missing tooth into the tooth socket. Additionally, a method of making a tooth scaffold is provided. The method includes synthesizing an acellular scaffold in the shape of a mammalian tooth and adding at least one compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic.Type: GrantFiled: June 17, 2010Date of Patent: March 17, 2015Assignee: The Trustees of Columbia University in the City of New YorkInventor: Jeremy J. Mao
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Publication number: 20150037382Abstract: This application provides a microsphere suitable for tissue engineering that comprises connective tissue growth factor (CTGF). Also provided is a matrix, material or scaffold suitable for tissue engineering that comprises connective tissue growth factor (CTGF) and basic fibroblast growth factor (bFGF). Additionally, methods of treating skin of a human are provided. The methods comprise administering to the skin microspheres comprising a growth factor that increases fibroblast proliferation or collagen, elastin, or glycosaminoglycan synthesis. Further provided are the use of the above microspheres for the treatment of the skin of a human. Additionally, this application proves the use of the above microsphere for the manufacture of a medicament for the treatment of the skin of a human.Type: ApplicationFiled: August 18, 2014Publication date: February 5, 2015Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Eduardo K. Moioli
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Publication number: 20140302111Abstract: Provided is a method for regenerating dental tissue, which can include contacting a scaffold containing Wnt3a and BMP-7, and optionally VEGF, bFGF, or NGF, with a dental tissue so as to promote odontoblastic differentiation of a progenitor cell, promote progenitor cell migration into the dental tissue, or regenerate the dental tissue. Also provided is a composition for regeneration of dental tissue, which can include a scaffold and Wnt3a and BMP-7, and optionally VEGF, bFGF, or NGF.Type: ApplicationFiled: March 21, 2014Publication date: October 9, 2014Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Ying Zheng, Guoming Sun, Songlin Wang
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Publication number: 20140093481Abstract: One aspect provides a method of forming a mineralized material by co-culturing a epithelial cell, such as ameloblasts, and mesenchymal cells, such as osteoblasts or odontoblasts, in a mineral-stimulating medium. Another aspect provides matrix seeded with epithelial cells and mesenchymal cells and infused with a mineral-stimulating medium capable of forming a mineralized material in the matrix. Methods of manufacturing such compositions and methods of treating mineralization-related conditions are also provided.Type: ApplicationFiled: October 3, 2011Publication date: April 3, 2014Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Mo Chen
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Publication number: 20140079739Abstract: Provided herein are compositions and methods for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells, such as mesenchymal stem cells. One aspect provides a fibrochondrocyte culture medium including CTGF and TGF?3, optionally encapsulated by microspheres having different release profiles. Another aspect provides a method for forming fibrochondrocytes or fibrochondrocyte-like cells from progenitor cells by culturing with CTGF and TGF?3.Type: ApplicationFiled: October 3, 2011Publication date: March 20, 2014Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Chang Hun Lee
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Publication number: 20140057842Abstract: Provided is a method of causing a cell to migrate to a scaffold and there differentiate to form adipose or adipose-like cells or tissue. Also provided is a method of treating a mammal that has a tissue defect. Further provided is a tissue scaffold comprising a cell homing composition and an adipogenic composition. Additionally, a method of making a tissue scaffold capable of recruiting a cell and differentiating the recruited cell to form adipose or adipose-like cells or tissue is provided.Type: ApplicationFiled: October 3, 2011Publication date: February 27, 2014Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Bhranti Shah
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Publication number: 20140050771Abstract: Provided is a method of causing a cell to migrate to a scaffold. Also provided is a method of treating a mammal that has a tissue defect. Further provided is a tissue scaffold comprising platelet-derived growth factor (PDGF). Additionally, a method of making a tissue scaffold capable of recruiting a cell is provided.Type: ApplicationFiled: October 3, 2011Publication date: February 20, 2014Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Wenli Zhao
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Publication number: 20130028978Abstract: Provided herein are compositions, methods, systems, and kits for wound healing. As shown herein, CCN2/CTGF stimulated mesenchymal progenitor cells can form ?SMA? fibroblasts. Further, TGF? was shown to stimulate further differentiation of ?SMA? fibroblasts to myofibroblasts associated with fibrosis. One aspect provides a composition including CCN2/CTGF and a TGF? inhibitor, a P38 inhibitor, or a tyrosine kinase inhibitor. Another aspect provides a method of treating tissue wounds with CCN2/CTGF-containing compositions. Also provided are systems and kits for wound healing. Also provided are methods for forming ?SMA? fibroblasts mesenchymal progenitor cells.Type: ApplicationFiled: November 10, 2010Publication date: January 31, 2013Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Chang Hun Lee
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Publication number: 20130022989Abstract: Provided is dental stem cell comprising an Oct3/4 transgene. Also provided is a method of making a pluripotent stem cell. Additionally, a method of preparing an insulin-secreting cell is provided. Further provided is an insulin-secreting cell prepared by that method. A method of preparing a chondrocyte-like cell is also provided, as is a chondrocyte-like cell prepared by that method. Additionally provided is a method of preparing a myocyte-like cell. Also, a myocyte-like cell prepared by that method is provided. A method of preparing a hair follicle-like cell is additionally provided, as is a hair follicle-like cell prepared by that method. A method of preparing a neuron-like cell is additionally provided, as is a neuron-like cell prepared by that method.Type: ApplicationFiled: June 25, 2010Publication date: January 24, 2013Applicant: The Trustees of Columbia University in the City of New YorkInventors: Jeremy J. Mao, Mo Chen
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Publication number: 20120282573Abstract: Provided is an acellular mammalian tooth-shaped scaffold comprising a compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic. Also provided is a method of replacing a tooth in the mouth of a mammal, where the tooth is absent and a tooth socket is present in the mouth at the position of the absent tooth. The method comprises implanting an acellular scaffold having the shape of the missing tooth into the tooth socket. Additionally, a method of making a tooth scaffold is provided. The method comprises synthesizing an acellular scaffold in the shape of a mammalian tooth and adding at least one compound that is chemotactic, osteogenic, dentinogenic, amelogenic, or cementogenic.Type: ApplicationFiled: June 17, 2010Publication date: November 8, 2012Applicant: The Trustees of Columbia University in the City of New YorkInventor: Jeremy J. Mao
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Publication number: 20110300203Abstract: Provided is a method of causing a cell to migrate to a scaffold. Also provided is a method of treating a mammal that has a cartilage defect. Further provided is a tissue scaffold comprising stromal cell-derived factor-1 (SDF-1) and transforming growth factor-? (TGF-?). Additionally, a method of making a tissue scaffold capable of recruiting a cell is provided.Type: ApplicationFiled: October 22, 2009Publication date: December 8, 2011Applicant: Trustees of Columbia University in the City of New YorkInventor: Jeremy J. Mao