Abstract: Integratable treatment devices, assemblies including a treatment device, at least one anchor, and a tether coupled thereto, and various methods and devices for inserting such devices and assemblies are disclosed herein. The treatment devices can be made of an integratable material that is not fully bioresorbable but promotes native tissue growth in and around the material. Certain methods involve first inserting at least one anchor and then advancing a treatment device via a tether coupled to the at least one anchor. Further various insertion devices that can be used to implant any of the treatment devices herein using any of the methods herein are disclosed.

Abstract: Subchondral bone analog materials and osteochondral constructs that incorporate the subchondral bone analogs are described. The subchondral bone analog materials include a biodegradable matrix, calcium phosphate particles (e.g., hydroxy apatite) and bioactive glass particles. The materials can exhibit sufficient mechanical strength and biochemical properties such that the materials can support boney integration and healing. Osteochondral constructs can include a first layer of the subchondral bone analog material, a second layer of a calcified cartilage analog material, and a third layer of a cartilage analog material.

Abstract: A hydrogel biomaterial that can be utilized as a nucleus pulposus replacement material is described. The hydrogel biomaterial can is an elastin-glycosaminoglycan-collagen composite hydrogel biomaterial that can mimic the biochemical and functional characteristics of the human nucleus pulposus. Methods for forming the hydrogel biomaterial are also described as are methods for use of the hydrogel biomaterial, one of which is as an in vivo nucleus pulposus replacement material, another of which is a scaffolding material for use in nucleus pulposus tissue engineering applications.

Abstract: A hydrogel biomaterial that can be utilized as a nucleus pulposus replacement material is described. The hydrogel biomaterial can is an elastin-glycosaminoglycan-collagen composite hydrogel biomaterial that can mimic the biochemical and functional characteristics of the human nucleus pulposus. Methods for forming the hydrogel biomaterial are also described as are methods for use of the hydrogel biomaterial, one of which is as an in vivo nucleus pulposus replacement material, another of which is a scaffolding material for use in nucleus pulposus tissue engineering applications.