Patents by Inventor Jeremy John Edmunds

Jeremy John Edmunds has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INHIBITORS OF FACTOR XA AND OTHER SERINE PROTEASES INVOLVED IN THE COAGULATION CASCADE
    Publication number: 20090221546
    Abstract: Compounds useful as intermediates for synthesis of compounds of Formula (1): wherein A, B, C, G, and W1 have any of the values defined in the specification.
    Type: Application
    Filed: June 16, 2008
    Publication date: September 3, 2009
    Inventors: Christopher Franklin Bigge, Agustin Casimiro-Garcia, Danette Andrea Dudley, Jeremy John Edmunds, Kevin James Filipski, Jeffrey Thomas Kohrt, Chad Alan Van Huis
  • Inhibitors of Factor XA and Other Serine Proteases Involved in the Coagulation Cascade
    Publication number: 20080287674
    Abstract: Compounds useful as intermediates for synthesis of compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification.
    Type: Application
    Filed: June 26, 2008
    Publication date: November 20, 2008
    Inventors: Christopher Franklin Bigge, Agustin Casimiro-Garcia, Danette Andrea Dudley, Jeremy John Edmunds, Kevin James Filipski, Jeffrey Thomas Kohrt, Chad Alan Van Huis
  • Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
    Patent number: 7407974
    Abstract: The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.
    Type: Grant
    Filed: April 18, 2005
    Date of Patent: August 5, 2008
    Assignee: Pfizer Inc.
    Inventors: Christopher Franklin Bigge, Agustin Casimiro-Garcia, Danette Andrea Dudley, Jeremy John Edmunds, Kevin James Filipski, Jeffrey Thomas Kohrt, Chad Alan Van Huis
  • Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
    Patent number: 7407972
    Abstract: The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.
    Type: Grant
    Filed: December 20, 2004
    Date of Patent: August 5, 2008
    Assignee: Pfizer Inc.
    Inventor: Jeremy John Edmunds
  • FACTOR Xa INHIBITOR
    Publication number: 20080171773
    Abstract: (R)-5-Methyl-4,5-dihydro-pyrazole-1,5-dicarboxylic acid 1-[(4-chloro-phenyl)-amide] 5-{[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide} pharmaceutical compositions, methods and methods of using the compound or pharmaceutical compositions thereof to treat diseases characterized by abnormal thrombosis in mammals.
    Type: Application
    Filed: November 29, 2007
    Publication date: July 17, 2008
    Inventors: Jeremy John Edmunds, Brian Matthew Samas
  • Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
    Patent number: 7030141
    Abstract: The present invention provides compounds of Formula (I): wherein A, B, C, G, and W1 have any of the values defined in the specification, and pharmaceutically acceptable salt thereof, that are useful to treat thrombotic disorders. Also disclosed are pharmaceutical compositions comprising one or more compounds of Formula I, processes for preparing compounds of Formula I, and intermediates useful for preparing compounds of Formula I.
    Type: Grant
    Filed: October 23, 2002
    Date of Patent: April 18, 2006
    Inventors: Christopher Franklin Bigge, Agustin Casimiro-Garcia, Danette Andrea Dudley, Jeremy John Edmunds, Kevin James Filipski, Jeffrey Thomas Kohrt, Chad Alan Van Huis
  • Quinoxalinones as serine protease inhibitors
    Patent number: 6916805
    Abstract: This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable compositions comprising the compounds, their salts or prodrugs, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: January 4, 2002
    Date of Patent: July 12, 2005
    Assignee: Warner-Lambert Company LLC
    Inventors: Danette Andrea Dudley, Jeremy John Edmunds
  • Quinolones as serine protease inhibitors
    Patent number: 6855726
    Abstract: The invention discloses quinolinones which display inhibitory effects on serine proteases such as factor Xa, thrombin and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable compositions comprising the compounds, their salts or prodrugs, and methods of using them a therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: December 15, 1998
    Date of Patent: February 15, 2005
    Assignee: Warner-Lambert Company LLC
    Inventors: Danette Andrea Dudley, Jeremy John Edmunds
  • Piperazine derivative renin inhibitors
    Publication number: 20040214832
    Abstract: Disclosed are piperazine derivatives, their manufacture and use as inhibitors of renin.
    Type: Application
    Filed: March 26, 2004
    Publication date: October 28, 2004
    Inventors: Cuiman Cai, Emma Hazel Clay, Dennis M. Downing, Jeremy John Edmunds, Daniel Dale Holsworth, Tingsheng Li, Noel Aaron Powell
  • Piperidine derivative rennin inhibitors
    Publication number: 20040204455
    Abstract: Disclosed are piperidine derivatives, their manufacture and use as inhibitors of renin.
    Type: Application
    Filed: March 26, 2004
    Publication date: October 14, 2004
    Inventors: Wayne Livingston Cody, Jeremy John Edmunds, Daniel Dale Holsworth, Noel Aaron Powell
  • Benoxazinones/benzothiazinones as serine protease inhibitors
    Publication number: 20030187256
    Abstract: This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
    Type: Application
    Filed: November 12, 2002
    Publication date: October 2, 2003
    Inventors: Kent Alan Berryman, Dennis Michael Downing, Danette Andrea Dudley, Jeremy John Edmunds, Lakshmi Sourirajan Narasimhan, Stephen Taras Rapundalo
  • Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
    Publication number: 20030162787
    Abstract: The present invention provides compounds of Formula (I): 1
    Type: Application
    Filed: October 23, 2002
    Publication date: August 28, 2003
    Inventors: Christopher Franklin Bigge, Agustin Casimiro-Garcia, Danette Andrea Dudley, Jeremy John Edmunds, Kevin James Filipski, Jeffrey Thomas Kohrt, Chad Alan Van Huis
  • Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
    Publication number: 20030073684
    Abstract: The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 1
    Type: Application
    Filed: June 3, 2002
    Publication date: April 17, 2003
    Inventors: Amy Mae Bunker, Xue-Min Cheng, Annette Marian Doherty, Jeremy John Edmunds, Gerald David Kanter, Chitase Lee, Joseph Thomas Repine, Richard William Skeean
  • Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
    Patent number: 6545150
    Abstract: The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
    Type: Grant
    Filed: December 5, 2001
    Date of Patent: April 8, 2003
    Assignee: Warner-Lambert Company
    Inventors: Amy Mae Bunker, Xue-Min Cheng, Annette Marian Doherty, Jeremy John Edmunds, Gerald David Kanter, Chitase Lee, Joseph Thomas Repine, Richard William Skeean
  • Benzoxazinoes/benzothiazinones as serine protease inhibitors
    Patent number: 6509335
    Abstract: This invention discloses benzoxazinone and benzothiazinone compounds which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnornal thrombosis.
    Type: Grant
    Filed: August 14, 2000
    Date of Patent: January 21, 2003
    Assignee: Warner-Lambert Company
    Inventors: Kent Alan Berryman, Dennis Michael Downing, Danette Andrea Dudley, Jeremy John Edmunds, Lakshmi Sourirajan Narasimhan, Stephen Taras Rapundalo
  • Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
    Patent number: 6440962
    Abstract: The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula I The compounds are useful in treating elevated levels of endothelin, essential renovascular malignant and pulmonary hypertension, cerebral infarction, cerebral ischemia, congestive heart failure, and subarachnoid hemorrhage.
    Type: Grant
    Filed: March 27, 2001
    Date of Patent: August 27, 2002
    Assignee: Warner-Lambert Company
    Inventors: Amy Mae Bunker, Xue-Min Cheng, Annette Marian Doherty, Jeremy John Edmunds, Gerald David Kanter, Chitase Lee, Joseph Thomas Repine, Richard William Skeean
  • Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
    Publication number: 20020094980
    Abstract: The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 1
    Type: Application
    Filed: December 5, 2001
    Publication date: July 18, 2002
    Inventors: Amy Mae Bunker, Xue-Min Cheng, Annette Marian Doherty, Jeremy John Edmunds, Gerald David Kanter, Chitase Lee, Joseph Thomas Repine, Richard William Skeean
  • Quinoxalinones as serine protease inhibitors
    Publication number: 20020086866
    Abstract: This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable compositions comprising the compounds, their salts or prodrugs, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
    Type: Application
    Filed: January 4, 2002
    Publication date: July 4, 2002
    Inventors: Danette Andrea Dudley, Jeremy John Edmunds
  • Quinoxalinones as serine protease inhibitors such as factor XA and thrombin
    Patent number: 6410536
    Abstract: This invention discloses quinoxalinones which display inhibitory effects on serine proteases such as factor Xa, thrombin, and/or factor VIIa. The invention also discloses pharmaceutically acceptable salts and prodrugs of the compounds, pharmaceutically acceptable compositions comprising the compounds, their salts or prodrugs, and methods of using them as therapeutic agents for treating or preventing disease states in mammals characterized by abnormal thrombosis.
    Type: Grant
    Filed: August 3, 2000
    Date of Patent: June 25, 2002
    Assignee: Warner-Lambert Company
    Inventors: Danette Andrea Dudley, Jeremy John Edmunds
  • Certain benzothiazine dioxide endothelin antagonists and processes for their preparation
    Publication number: 20010036944
    Abstract: The instant invention is a series of benzothiazine dioxides, or a pharmaceutically acceptable salt thereof, which are potent endothelin A antagonists with profound in vitro activity, and improved syntheses for the Formula 1 1
    Type: Application
    Filed: March 27, 2001
    Publication date: November 1, 2001
    Inventors: Amy Mae Bunker, Xue-Min Cheng, Annette Marian Doherty, Jeremy John Edmunds, Gerald David Kanter, Chitase Lee, Joseph Thomas Repine, Richard William Skeean