Abstract: A method for filling a dispensing bag includes inserting a collapsed bag within the chamber of a bin, the chamber being bounded by a floor and an upstanding sidewall. A first port formed on the collapsed bag is securely fixed within a port hole formed on the floor of the bin. A hoist mounted on the bin is manipulated so that the hoist raises an upper end of the collapsed bag within the chamber while the first port remains fixed within the port hole so as to expand the collapsed bag within the chamber of the bin.

Abstract: A fluid bin assembly includes a bin having a floor with a side wall upstanding from the floor. The floor and the side wall bound a chamber. An opening extends through the floor and communicates with the chamber. One or more retention plates are removably mounted to the floor of the bin so as to at least partially cover the opening extending through the floor. The retention plates at least partially bound one or more portholes that openly communicate with the chamber of the bin.

Abstract: A process for making a microneedle array master comprises: (a) providing a photoreactive composition, the photoreactive composition comprising: (1) at least one reactive species that is capable of undergoing an acid- or radical-initiated chemical reaction, and (2) at least one multiphoton photoinitiator system; and (b) imagewise exposing at least a portion of the composition to light sufficient to cause simultaneous absorption of at least two photons, thereby inducing at least one acid- or radical-initiated chemical reaction where the composition is exposed to the light, the imagewise exposing being carried out in a pattern that is effective to define at least the surface of a plurality of microneedles. The microneedles may be solid and the outer surface of the microneedles may be characterized by at least one concave area. The master may be used to fabricate a tool for replication.

Abstract: The present invention relates to a stirred-tank reactor system and methods of preparing such systems. The present invention further encompasses the use of the stirred-tank reactor system as a disposable bioreactor and in kits with disposable elements.

Abstract: A fluid bin assembly includes a bin having a floor with a side wall upstanding therefrom. The floor and the side wall bound a chamber. The floor has an opening extending therethrough that communicates with the chamber. A retention plate is removably mounted to the floor of the bin so as to at least partially cover the opening extending therethrough. The retention plate at least partially bounds a porthole that openly communicates with the chamber of the bin.

Abstract: A container system includes a substantially rigid container having a floor and a side wall upstanding therefrom. The side wall and floor bound a chamber. A magnetic mixer is disposed below the floor of the container. A mixing bag assembly is disposed within the chamber of the container. The mixing bag assembly includes a collapsible body having a first end and an opposing second end. The collapsible body bounds a compartment. A mixing dish is disposed at the second end of the collapsible body so as to communicate with the compartment thereof. A magnetic stir bar is disposed on the mixing dish.

Abstract: A container system includes a substantially rigid container having a floor and a side wall upstanding therefrom. The side wall and floor bound a chamber. A magnetic mixer is disposed below the floor of the container. A mixing bag assembly is disposed within the chamber of the container. The mixing bag assembly includes a collapsible body having a first end and an opposing second end. The collapsible body bounds a compartment. A mixing dish is disposed at the second end of the collapsible body so as to communicate with the compartment thereof. A magnetic stir bar is disposed on the mixing dish.

Abstract: A method for manufacturing an optical waveguide device in accordance with the present invention includes the steps of depositing a lower cladding layer; coating a photoresist layer directly on the lower cladding layer; patterning the photoresist layer to create channels; depositing a core layer, wherein a first portion of the core layer is deposited inside the channels and a second portion overlays the patterned photoresist layer; removing the patterned photoresist layer and the second portions of the core layer overlaying the patterned photoresist layer; and depositing an upper cladding layer.

Abstract: A fluid bin assembly includes a bin having a floor with a side wall upstanding therefrom. The floor and the side wall bound a chamber. The floor has an opening extending therethrough that communicates with the chamber. A retention plate is removably mounted to the floor of the bin so as to at least partially cover the opening extending therethrough. The retention plate at least partially bounds a porthole that openly communicates with the chamber of the bin.

Abstract: A container system includes a substantially rigid container having a floor and a side wall upstanding therefrom. The side wall and floor bound a chamber. A magnetic mixer is disposed below the floor of the container. A mixing bag assembly is disposed within the chamber of the container. The mixing bag assembly includes a collapsible body having a first end and an opposing second end. The collapsible body bounds a compartment. A mixing dish is disposed at the second end of the collapsible body so as to communicate with the compartment thereof. A magnetic stir bar is disposed on the mixing dish.

Abstract: A method for manufacturing an optical waveguide device in accordance with the present invention includes the steps of depositing a lower cladding layer; coating a photoresist layer directly on the lower cladding layer; patterning the photoresist layer to create channels; depositing a core layer, wherein a first portion of the core layer is deposited inside the channels and a second portion overlays the patterned photoresist layer; removing the patterned photoresist layer and the second portions of the core layer overlaying the patterned photoresist layer; and depositing an upper cladding layer.