Abstract: Methods, systems, and computer readable media for predictively determining a risk of damage to a property are provided. To determine the risk, a high resolution virtual model of a region that includes the property is obtained. The virtual model is imported into a simulation environment. One or more of the simulation parameters are set based on historic weather data for the region. For example, each parameter may be associated with a probability distribution derived based on the historic weather data that is sampled prior to executing the simulation. One or more simulations are executed in accordance with the sampled inputs to simulate the likely weather patterns the property will experience. The result of the simulation is analyzed to determine the predicted risk of damage to the property.

Abstract: Provided herein are, inter alia, novel peptide compositions having multi-specific binding capabilities useful for therapeutic and diagnostic purposes. The peptide compositions provided herein are polypeptide conjugates including at least two ligand binding domains able to target (bind) two or more ligands (e.g., antigens) at the same time. The peptide compositions provided herein can be produced at very high yields and are therefore easy to manufacture.

Abstract: A semiconductor device includes a semiconductor structure comprising first and second semiconductor layers having different bandgaps, first and second contacts on the semiconductor structure and free of a gate structure therebetween, and a resistor comprising a portion of the semiconductor structure that electrically connects the first and second contacts. The portion of the semiconductor structure may be a second portion of the second semiconductor layer that is recessed in thickness relative to a first portion thereof, and/or may include a passivation layer in direct contact with the second semiconductor layer. Related devices, packages, and fabrication methods are discussed.

Abstract: A method of processing objects with a programmable motion device is disclosed. The method includes receiving a plurality of received objects at an input area proximate the programmable motion device, selecting and grasping a first object of the plurality of received objects from the input area using the programmable motion device, moving the first object to a cache area using the programmable motion device, said cache area being proximate the programmable motion device, selecting and grasping a second object of the plurality of received objects, moving the second object to a first destination location using the programmable motion device, selecting and grasping the first object from the cache area using the programmable motion device, and moving the first object to the first destination location using the programmable motion device.

Abstract: Provided herein are, inter alia, novel peptide compositions having multi-specific binding capabilities useful for therapeutic and diagnostic purposes. The peptide compositions provided herein are polypeptide conjugates including at least two ligand binding domains able to target (bind) two or more ligands (e.g., antigens) at the same time. The peptide compositions provided herein can be produced at very high yields and are therefore easy to manufacture.

Abstract: Systems and methods for operating a vehicle that includes an engine that may be automatically stopped and started are described. In one example, inhibiting of automatic engine stopping and starting may be based on comparing an engine off opportunity and a plurality of auxiliary logic performances. The plurality of auxiliary logic performances may be based on a plurality of auxiliary control routine blocks.

Abstract: A cold plate can include a first end, a second end opposite the first end, and a plurality of channels therein. A first plurality of channels can run from the first end to the second end. A second plurality of channels can run from the second end to the first end. The first and second pluralities of channels can be interleaved. The cold plate can include first and second outlet ports of greater height and width than first and second inlet ports, and a third outlet port of greater height and width than a third inlet port. A third channel can be disposed at least partially between first and second channels.

Abstract: Described is a method and device for detecting an analyte in a sample, comprising bringing a sample comprising a target analyte into contact with magnetisable particles, the particles being coated with binding molecules complementary to the target analyte, resulting in bound and unbound binder complexes, positioning the magnetisable particles, comprising both bound and unbound binder complexes, in proximity to a magnetic field sensor, changing the magnetic field sufficient to release at least a portion of the magnetisable particles, comprising both bound and unbound binder complexes, from their proximity to the magnetic field sensor, and measuring changes in a magnetic signal detected from the net movement, being either translational or rotational movement, of the magnetisable particles relative to the magnetic sensor.

Abstract: Described is a method and device for detecting an analyte in a sample, comprising bringing a sample comprising a target analyte into contact with magnetisable particles, the particles being coated with binding molecules complementary to the target analyte, resulting in bound and unbound binder complexes, positioning the magnetisable particles, comprising both bound and unbound binder complexes, in proximity to a magnetic field sensor, changing the magnetic field sufficient to release at least a portion of the magnetisable particles, comprising both bound and unbound binder complexes, from their proximity to the magnetic field sensor, and measuring changes in a magnetic signal detected from the net movement, being either translational or rotational movement, of the magnetisable particles relative to the magnetic sensor.

Abstract: A fuel assembly for a nuclear reactor having an upstream minor portion defining an upstream end, a main portion, and a downstream minor portion defining a downstream end. Fuel rods extend in a flow interspace permitting a flow of coolant through the fuel assembly in contact with the fuel rods. Two elongated tubes form a respective internal passage extending in parallel with the fuel rods and enclosing a stream of the coolant. Each elongated tube having a bottom, an inlet at the upstream minor portion and an outlet at the downstream minor portion. Each elongated tube having an inlet pipe having an inlet end and an outlet end in the internal passage at a distance from the bottom, thereby forming a space in the internal passage between the outlet end and the bottom.

Abstract: Systems and methods including one or more processors and one or more non-transitory storage devices storing computing instructions configured to run on the one or more processors and cause the one or more processors to perform tracking, using the one or more processors, usage history of a user; creating training data from the usage history of the user; training a predictive algorithm on the training data; for each respective promotion in a plurality of promotions: assigning a respective weight to the respective promotion of the plurality of promotions by using the predictive algorithm, as trained; after a predetermined time period has elapsed, updating the usage history of the user; re-training the predictive algorithm, as trained, on the usage history of the user, as updated; for each respective promotion in the plurality of promotions: assigning a new respective weight to the respective promotion of the plurality of promotions using the predictive algorithm, as trained and re-trained; and coordinating displ

Abstract: A system and method for providing a customized user experience is presented. A system can include one or more processing modules and one more non-transitory storage modules. The usage history of a user can be tracked at an eCommerce retailer. Static information about the user can also be tracked. Thereafter, using the usage history, the static information, and the available promotions of the retailer, a probability of conversion can be calculated for each promotion. Thereafter, the promotion being displayed to the user can be based on the probability of conversion. Other embodiments are also disclosed herein.

Abstract: Described is a method and device for detecting an analyte in a sample, comprising bringing a sample comprising a target analyte into contact with magnetisable particles, the particles being coated with binding molecules complementary to the target analyte, resulting in bound and unbound binder complexes, positioning the magnetisable particles, comprising both bound and unbound binder complexes, in proximity to a magnetic field sensor, changing the magnetic field sufficient to release at least a portion of the magnetisable particles, comprising both bound and unbound binder complexes, from their proximity to the magnetic field sensor, and measuring changes in a magnetic signal detected from the net movement, being either translational or rotational movement, of the magnetisable particles relative to the magnetic sensor.

Abstract: Provided herein are, inter alia, novel peptide compositions having multi-specific binding capabilities useful for therapeutic and diagnostic purposes. The peptide compositions provided herein are polypeptide conjugates including at least two ligand binding domains able to target (bind) two or more ligands (e.g., antigens) at the same time. The peptide compositions provided herein can be produced at very high yields and are therefore easy to manufacture.

Abstract: Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments covalently linked to a peptide compound through a disulfide linkage. The disulfide linkage is between a cysteine in the Fab region of the antibody or fragment thereof and a thiol moiety of a side chain amino acid of the peptide compound. The covalently formed complexes including provided herein form highly stable and versatile drug delivery and diagnostic compositions.

Abstract: A fuel assembly for a nuclear reactor having an upstream minor portion defining an upstream end, a main portion, and a downstream minor portion defining a downstream end. Fuel rods extend in a flow interspace permitting a flow of coolant through the fuel assembly in contact with the fuel rods. Two elongated tubes form a respective internal passage extending in parallel with the fuel rods and enclosing a stream of the coolant. Each elongated tube having a bottom, an inlet at the upstream minor portion and an outlet at the downstream minor portion. Each elongated tube having an inlet pipe having an inlet end and an outlet end in the internal passage at a distance from the bottom, thereby forming a space in the internal passage between the outlet end and the bottom.

Abstract: A system and method for providing a customized user experience is presented. A system can include one or more processing modules and one more non-transitory storage modules. The usage history of a user can be tracked at an eCommerce retailer. Static information about the user can also be tracked. Thereafter, using the usage history, the static information, and the available promotions of the retailer, a probability of conversion can be calculated for each promotion. Thereafter, the promotion being displayed to the user can be based on the probability of conversion. Other embodiments are also disclosed herein.

Abstract: A system for managing adaptive security zones in complex business operations, comprising a rules engine adapted to receive events from a plurality of event sources and a security manager coupled to the rules engine via a data network, wherein upon receiving an event, the rules engine determines what rules, if any, are triggered by the event and, upon triggering a rule, the rules engine determines if the rule pertains to security and, if so, sends a notification message to the security manager informing it of the triggered event, and wherein the security manager, on receiving a notification message from the rules engine, automatically establishes a new security zone based at least in part on the contents of the notification message, is disclosed.

Abstract: According to one general aspect, a method may include requesting, from a database and by a program executing on a mobile computing device, at least a portion of a business service context regarding a business service. The method may also include receiving, from the database, an aggregated database result regarding the business service. The aggregated database result may include the requested business service context and wherein the business service context includes information from a plurality of applications. The method may also include displaying, via the mobile computing device, at least a portion of the information included by the business service context.

Abstract: A system for managing adaptive security zones in complex business operations, comprising a rules engine adapted to receive events from a plurality of event sources and a security manager coupled to the rules engine via a data network, wherein upon receiving an event, the rules engine determines what rules, if any, are triggered by the event and, upon triggering a rule, the rules engine determines if the rule pertains to security and, if so, sends a notification message to the security manager informing it of the triggered event, and wherein the security manager, on receiving a notification message from the rules engine, automatically establishes a new security zone based at least in part on the contents of the notification message, is disclosed.