Abstract: Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments covalently linked to a peptide compound through a disulfide linkage. The disulfide linkage is between a cysteine in the Fab region of the antibody or fragment thereof and a thiol moiety of a side chain amino acid of the peptide compound. The covalently formed complexes including provided herein form highly stable and versatile drug delivery and diagnostic compositions.

Abstract: Described is an apparatus comprising magnetisable particles adapted for binding to an analyte, the apparatus comprising a sensing zone comprising least an array of magnetic field sensors, a sample introduction device configured to introduce the sample to the sensing zone, optionally a field generator (optimised for magnetic and/or electric field generation) if the magnetisable particles do not have an aligned dipole moment, a controller connected to receive signals from the array of magnetic and/or electric field, the controller configured to determine an amount of analyte in the sample based on the signals received from the array of magnetic and/or electric field sensors, and an additional feature selected from one or more of a set and reset module or capability for performing a set/reset of the magnetic sensors, a data transmission layer, that is configured to shield the signals being transmitted from the one or more magnetic sensors, a plurality of magnetic field transmission zones corresponding to an area

Abstract: Input/output (I/O) components can include electromechanical switches that can be placed respectively on signal lines coupled between transceivers and I/O pads. Electromechanical switches can operate to isolate respective transceivers from the other transceivers and/or I/O pads to protect those transceivers from ESD events. Electromechanical switches of I/O components can be micro-electromechanical systems (MEMS) switches.

Abstract: Provided herein are, inter alia, novel peptide compositions having multi-specific binding capabilities useful for therapeutic and diagnostic purposes. The peptide compositions provided herein are polypeptide conjugates including at least two ligand binding domains able to target (bind) two or more ligands (e.g., antigens) at the same time. The peptide compositions provided herein can be produced at very high yields and are therefore easy to manufacture.

Abstract: Provided herein are, inter alia, novel peptide compositions having multi-specific binding capabilities useful for therapeutic and diagnostic purposes. The peptide compositions provided herein are polypeptide conjugates including at least two ligand binding domains able to target (bind) two or more ligands (e.g., antigens) at the same time. The peptide compositions provided herein can be produced at very high yields and are therefore easy to manufacture.

Abstract: A cold plate can include a first end, a second end opposite the first end, and a plurality of channels therein. A first plurality of channels can run from the first end to the second end. A second plurality of channels can run from the second end to the first end. The first and second pluralities of channels can be interleaved. The cold plate can include first and second outlet ports of greater height and width than first and second inlet ports, and a third outlet port of greater height and width than a third inlet port. A third channel can be disposed at least partially between first and second channels.

Abstract: Described is a method and device for detecting an analyte in a sample, comprising bringing a sample comprising a target analyte into contact with magnetisable particles, the particles being coated with binding molecules complementary to the target analyte, resulting in bound and unbound binder complexes, positioning the magnetisable particles, comprising both bound and unbound binder complexes, in proximity to a magnetic field sensor, changing the magnetic field sufficient to release at least a portion of the magnetisable particles, comprising both bound and unbound binder complexes, from their proximity to the magnetic field sensor, and measuring changes in a magnetic signal detected from the net movement, being either translational or rotational movement, of the magnetisable particles relative to the magnetic sensor.

Abstract: Described is a method and device for detecting an analyte in a sample, comprising bringing a sample comprising a target analyte into contact with magnetisable particles, the particles being coated with binding molecules complementary to the target analyte, resulting in bound and unbound binder complexes, positioning the magnetisable particles, comprising both bound and unbound binder complexes, in proximity to a magnetic field sensor, changing the magnetic field sufficient to release at least a portion of the magnetisable particles, comprising both bound and unbound binder complexes, from their proximity to the magnetic field sensor, and measuring changes in a magnetic signal detected from the net movement, being either translational or rotational movement, of the magnetisable particles relative to the magnetic sensor.

Abstract: A fuel assembly for a nuclear reactor having an upstream minor portion defining an upstream end, a main portion, and a downstream minor portion defining a downstream end. Fuel rods extend in a flow interspace permitting a flow of coolant through the fuel assembly in contact with the fuel rods. Two elongated tubes form a respective internal passage extending in parallel with the fuel rods and enclosing a stream of the coolant. Each elongated tube having a bottom, an inlet at the upstream minor portion and an outlet at the downstream minor portion. Each elongated tube having an inlet pipe having an inlet end and an outlet end in the internal passage at a distance from the bottom, thereby forming a space in the internal passage between the outlet end and the bottom.

Abstract: Systems and methods including one or more processors and one or more non-transitory storage devices storing computing instructions configured to run on the one or more processors and cause the one or more processors to perform tracking, using the one or more processors, usage history of a user; creating training data from the usage history of the user; training a predictive algorithm on the training data; for each respective promotion in a plurality of promotions: assigning a respective weight to the respective promotion of the plurality of promotions by using the predictive algorithm, as trained; after a predetermined time period has elapsed, updating the usage history of the user; re-training the predictive algorithm, as trained, on the usage history of the user, as updated; for each respective promotion in the plurality of promotions: assigning a new respective weight to the respective promotion of the plurality of promotions using the predictive algorithm, as trained and re-trained; and coordinating displ

Abstract: A system and method for providing a customized user experience is presented. A system can include one or more processing modules and one more non-transitory storage modules. The usage history of a user can be tracked at an eCommerce retailer. Static information about the user can also be tracked. Thereafter, using the usage history, the static information, and the available promotions of the retailer, a probability of conversion can be calculated for each promotion. Thereafter, the promotion being displayed to the user can be based on the probability of conversion. Other embodiments are also disclosed herein.

Abstract: Described is a method and device for detecting an analyte in a sample, comprising bringing a sample comprising a target analyte into contact with magnetisable particles, the particles being coated with binding molecules complementary to the target analyte, resulting in bound and unbound binder complexes, positioning the magnetisable particles, comprising both bound and unbound binder complexes, in proximity to a magnetic field sensor, changing the magnetic field sufficient to release at least a portion of the magnetisable particles, comprising both bound and unbound binder complexes, from their proximity to the magnetic field sensor, and measuring changes in a magnetic signal detected from the net movement, being either translational or rotational movement, of the magnetisable particles relative to the magnetic sensor.

Abstract: Provided herein are, inter alia, novel peptide compositions having multi-specific binding capabilities useful for therapeutic and diagnostic purposes. The peptide compositions provided herein are polypeptide conjugates including at least two ligand binding domains able to target (bind) two or more ligands (e.g., antigens) at the same time. The peptide compositions provided herein can be produced at very high yields and are therefore easy to manufacture.

Abstract: Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments covalently linked to a peptide compound through a disulfide linkage. The disulfide linkage is between a cysteine in the Fab region of the antibody or fragment thereof and a thiol moiety of a side chain amino acid of the peptide compound. The covalently formed complexes including provided herein form highly stable and versatile drug delivery and diagnostic compositions.

Abstract: A fuel assembly for a nuclear reactor having an upstream minor portion defining an upstream end, a main portion, and a downstream minor portion defining a downstream end. Fuel rods extend in a flow interspace permitting a flow of coolant through the fuel assembly in contact with the fuel rods. Two elongated tubes form a respective internal passage extending in parallel with the fuel rods and enclosing a stream of the coolant. Each elongated tube having a bottom, an inlet at the upstream minor portion and an outlet at the downstream minor portion. Each elongated tube having an inlet pipe having an inlet end and an outlet end in the internal passage at a distance from the bottom, thereby forming a space in the internal passage between the outlet end and the bottom.

Abstract: A system and method for providing a customized user experience is presented. A system can include one or more processing modules and one more non-transitory storage modules. The usage history of a user can be tracked at an eCommerce retailer. Static information about the user can also be tracked. Thereafter, using the usage history, the static information, and the available promotions of the retailer, a probability of conversion can be calculated for each promotion. Thereafter, the promotion being displayed to the user can be based on the probability of conversion. Other embodiments are also disclosed herein.

Abstract: A system for managing adaptive security zones in complex business operations, comprising a rules engine adapted to receive events from a plurality of event sources and a security manager coupled to the rules engine via a data network, wherein upon receiving an event, the rules engine determines what rules, if any, are triggered by the event and, upon triggering a rule, the rules engine determines if the rule pertains to security and, if so, sends a notification message to the security manager informing it of the triggered event, and wherein the security manager, on receiving a notification message from the rules engine, automatically establishes a new security zone based at least in part on the contents of the notification message, is disclosed.

Abstract: According to one general aspect, a method may include requesting, from a database and by a program executing on a mobile computing device, at least a portion of a business service context regarding a business service. The method may also include receiving, from the database, an aggregated database result regarding the business service. The aggregated database result may include the requested business service context and wherein the business service context includes information from a plurality of applications. The method may also include displaying, via the mobile computing device, at least a portion of the information included by the business service context.

Abstract: A system for managing adaptive security zones in complex business operations, comprising a rules engine adapted to receive events from a plurality of event sources and a security manager coupled to the rules engine via a data network, wherein upon receiving an event, the rules engine determines what rules, if any, are triggered by the event and, upon triggering a rule, the rules engine determines if the rule pertains to security and, if so, sends a notification message to the security manager informing it of the triggered event, and wherein the security manager, on receiving a notification message from the rules engine, automatically establishes a new security zone based at least in part on the contents of the notification message, is disclosed.

Abstract: According to one general aspect, a method of using an application may include receiving a request, from a user, to display at least a portion of a business service context regarding a business service. The method may also include receiving, from a database, an aggregated database result regarding the business service. The aggregated database result may include the requested business service context. The business service context may include information from a plurality of other applications. The method may further include displaying a graphical user interface element that displays at least a portion of the information included by the business service context.