Patents by Inventor Jeremy L. Norris

Jeremy L. Norris has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10996227
    Abstract: Pre-coated analysis substrates, and methods of making the substrates and using them to analyze animal tissue, are described. The pre-coated analysis substrates can be made by forming a matrix surface on an analysis substrate; adding a protease to the matrix surface to form a pre-coated analysis substrate; and placing an animal tissue specimen on the matrix surface. The animal tissue can then be analyzed by allowing the protease to partially digest the animal tissue specimen; and analyzing the partially digested animal tissue specimen by mass spectrometry.
    Type: Grant
    Filed: June 9, 2016
    Date of Patent: May 4, 2021
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Richard Caprioli, Junhai Yang, Jeremy L. Norris, Faizan Zubair, Paul Edward Laibinis
  • Patent number: 10877040
    Abstract: The present invention is directed to a mass spectrometry approach to identifying non-Spitzoid melanoma, and distinguishing non-Spitzoid nevi from non-Spitzoid malignant melanoma.
    Type: Grant
    Filed: April 29, 2019
    Date of Patent: December 29, 2020
    Assignee: FRONTIER DIAGNOSTICS, LLC
    Inventors: Jeremy L. Norris, Richard M. Caprioli, Jason B. Robbins
  • Publication number: 20200341004
    Abstract: The present invention is directed to a mass spectrometry approach to identifying carcinomas or tissue abnormalities, and distinguishing carcinomas or tissue abnormalities.
    Type: Application
    Filed: October 29, 2018
    Publication date: October 29, 2020
    Inventors: Jeremy L. Norris, Richard M. Caprioli, Jason B. Robbins, Jessica Lindsey Moore, Nathan Heath Patterson
  • Patent number: 10607721
    Abstract: The present disclosure provides for rapid identification of mechanism of action (MOA) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: March 31, 2020
    Assignee: VANDERBILT UNIVERSITY
    Inventors: Richard Caprioli, John Wikswo, John McLean, Eric Skaar, Jeremy L. Norris, Dana Borden Lacy, Stacy Sherrod, James Pino, Danielle Gutierrez, Nicole D. Muszynski, Melissa Farrow
  • Publication number: 20170082606
    Abstract: The present disclosure provides for rapid identification of mechanism of action (MOA) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.
    Type: Application
    Filed: September 22, 2016
    Publication date: March 23, 2017
    Applicant: Vanderbilt University
    Inventors: Richard CAPRIOLI, John WIKSWO, John MCLEAN, Eric SKAAR, Jeremy L. Norris
  • Publication number: 20170067906
    Abstract: Pre-coated analysis substrates, and methods of making the substrates and using them to analyze animal tissue, are described. The pre-coated analysis substrates can be made by forming a matrix surface on an analysis substrate; adding a protease to the matrix surface to form a pre-coated analysis substrate; and placing an animal tissue specimen on the matrix surface. The animal tissue can then be analyzed by allowing the protease to partially digest the animal tissue specimen; and analyzing the partially digested animal tissue specimen by mass spectrometry.
    Type: Application
    Filed: June 9, 2016
    Publication date: March 9, 2017
    Inventors: Richard Caprioli, Junhai Yang, Jeremy L. Norris, Faizan Zubair, Paul Edward Laibinis
  • Publication number: 20170023547
    Abstract: Systems and methods for characterizing the cellular response of one or more animal cells to a chemical agent are described. The method includes the steps of: exposing one or more animal cells to a chemical agent; generating data representing an altered molecular phenotype of the one or more animal cells after exposure to the chemical agent using a multi-omic analysis; providing the data representing the altered molecular phenotype to a system comprising a processor; using the system to compare the data representing the altered molecular phenotype with data representing a normal molecular phenotype of the one or more animal cells; and using the system to output a characterization of the cellular response of the one or more animal cells to the chemical agent based on the results of comparing the data.
    Type: Application
    Filed: July 25, 2016
    Publication date: January 26, 2017
    Inventors: Jeremy L. Norris, Richard M. Caprioli
  • Publication number: 20160126073
    Abstract: A diagnostic system and method that includes a non-transitory computer readable medium storing machine executable instructions executable by the processor for altering tissue images, the instructions that further includes an input interface configured to receive a plurality of tissue images, the input interface generating enhanced resolution images from the plurality of tissue images for viewing, an annotation interface for positioning coordinates of interest on the enhanced resolution images, and a matrix model configured to evaluate the coordinates of interest on the enhanced resolutions to generate discrete coordinates, the matrix model using the discrete coordinates in performing mass spectrometer analysis to form at least one viewing image. The system also includes a user interface configured to provide at least one viewing image to a user at the display.
    Type: Application
    Filed: June 9, 2014
    Publication date: May 5, 2016
    Inventors: Jeremy L. Norris, Erin H. Seeley, Tina Tsui, Richard M. Caprioli
  • Patent number: 8697447
    Abstract: The present invention includes a cleavable surfactant/detergent compound of the following formula: wherein the variables are defined herein. Embodiments of the cleavable surfactant/detergent compound are useful, for example, in methods for isolating a hydrophobic molecule that include providing a plasma comprising a hydrophobic molecule, applying the cleavable surfactant to the plasma so that the surfactant engages the hydrophobic molecule, cleaving the surfactant from the hydrophobic molecule, and analyzing said hydrophobic molecule.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: April 15, 2014
    Assignee: Vanderbilt University
    Inventors: Richard M Caprioli, Ned A. Porter, Jeremy L. Norris
  • Publication number: 20110217783
    Abstract: Cleavable compositions that comprise a polar head, cleavable linker, and a hydrophobic tail; and methods for using them to isolate hydrophobic molecules.
    Type: Application
    Filed: November 15, 2010
    Publication date: September 8, 2011
    Inventors: Richard M. Caprioli, Ned A. Porter, Jeremy L. Norris
  • Patent number: 7858388
    Abstract: A method of modifying protein samples that comprises combining the sample with a peroxycarbonate solution and inserting the sample into a mass spectrometer. The present invention also includes methods of N-terminus characterization.
    Type: Grant
    Filed: October 14, 2004
    Date of Patent: December 28, 2010
    Assignee: Vanderbilt University
    Inventors: Ned A. Porter, Douglas S. Masterson, Huiyong Yin, Richard M. Caprioli, Jeremy L. Norris
  • Publication number: 20090071834
    Abstract: A device is described for pre-concentration and purification of analytes from biological samples (such as human serum, plasma, homogenized solid tissue, etc.) to be analyzed by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) and methods of use thereof are provided.
    Type: Application
    Filed: June 9, 2008
    Publication date: March 19, 2009
    Applicant: PROTEIN DISCOVERY, INC.
    Inventors: Dean G. Hafeman, James B. Harkins, IV, Jeremy L. Norris, Sheila N. Baker, Donald R. Loveday, Daniel P. Kuban, Richard M. Caprioli, Charles E. Witkowski, II, Benjamin B. Katz, Salvadore J. Pastor
  • Publication number: 20080113875
    Abstract: The present invention provides methods for obtaining information of a plurality of target molecules by matrix free LDI MS. Mass tagged complexes for detection of target molecules comprise a target molecule binding domain, and a mass tag separated by a cleavable linker. Methods of the invention may be used for example to analyze the distribution of a multiple target molecules in a complex sample, such as a tissue section.
    Type: Application
    Filed: September 7, 2007
    Publication date: May 15, 2008
    Inventors: Pierre Chaurand, Jeremy L. Norris, Ned A. Porter, Junhai Yang, Richard M. Caprioli
  • Patent number: 7074936
    Abstract: Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins.
    Type: Grant
    Filed: May 28, 2002
    Date of Patent: July 11, 2006
    Assignee: Vanderbilt University
    Inventors: Richard M. Caprioli, Ned A. Porter, Jeremy L. Norris
  • Publication number: 20040152913
    Abstract: Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins.
    Type: Application
    Filed: December 1, 2003
    Publication date: August 5, 2004
    Inventors: Richard M Caprioli, Ned A Porter, Jeremy L Norris