Abstract: The present invention is directed to a mass spectrometry approach to identifying non-Spitzoid melanoma, and distinguishing non-Spitzoid nevi from non-Spitzoid malignant melanoma.

Abstract: Pre-coated analysis substrates, and methods of making the substrates and using them to analyze animal tissue, are described. The pre-coated analysis substrates can be made by forming a matrix surface on an analysis substrate; adding a protease to the matrix surface to form a pre-coated analysis substrate; and placing an animal tissue specimen on the matrix surface. The animal tissue can then be analyzed by allowing the protease to partially digest the animal tissue specimen; and analyzing the partially digested animal tissue specimen by mass spectrometry.

Abstract: The present invention is directed to a mass spectrometry approach to identifying non-Spitzoid melanoma, and distinguishing non-Spitzoid nevi from non-Spitzoid malignant melanoma.

Abstract: The present invention is directed to a mass spectrometry approach to identifying carcinomas or tissue abnormalities, and distinguishing carcinomas or tissue abnormalities.

Abstract: The present disclosure provides for rapid identification of mechanism of action (MOA) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.

Abstract: The present disclosure provides for rapid identification of mechanism of action (MOA) for drugs and toxins, and does so in a rapid (30 days or less) fashion. The methods use a combination of high throughput bioinformatics and pathway analysis that examine a wide variety of biological parametics.

Abstract: Pre-coated analysis substrates, and methods of making the substrates and using them to analyze animal tissue, are described. The pre-coated analysis substrates can be made by forming a matrix surface on an analysis substrate; adding a protease to the matrix surface to form a pre-coated analysis substrate; and placing an animal tissue specimen on the matrix surface. The animal tissue can then be analyzed by allowing the protease to partially digest the animal tissue specimen; and analyzing the partially digested animal tissue specimen by mass spectrometry.

Abstract: Systems and methods for characterizing the cellular response of one or more animal cells to a chemical agent are described. The method includes the steps of: exposing one or more animal cells to a chemical agent; generating data representing an altered molecular phenotype of the one or more animal cells after exposure to the chemical agent using a multi-omic analysis; providing the data representing the altered molecular phenotype to a system comprising a processor; using the system to compare the data representing the altered molecular phenotype with data representing a normal molecular phenotype of the one or more animal cells; and using the system to output a characterization of the cellular response of the one or more animal cells to the chemical agent based on the results of comparing the data.

Abstract: A diagnostic system and method that includes a non-transitory computer readable medium storing machine executable instructions executable by the processor for altering tissue images, the instructions that further includes an input interface configured to receive a plurality of tissue images, the input interface generating enhanced resolution images from the plurality of tissue images for viewing, an annotation interface for positioning coordinates of interest on the enhanced resolution images, and a matrix model configured to evaluate the coordinates of interest on the enhanced resolutions to generate discrete coordinates, the matrix model using the discrete coordinates in performing mass spectrometer analysis to form at least one viewing image. The system also includes a user interface configured to provide at least one viewing image to a user at the display.

Abstract: The present invention includes a cleavable surfactant/detergent compound of the following formula: wherein the variables are defined herein. Embodiments of the cleavable surfactant/detergent compound are useful, for example, in methods for isolating a hydrophobic molecule that include providing a plasma comprising a hydrophobic molecule, applying the cleavable surfactant to the plasma so that the surfactant engages the hydrophobic molecule, cleaving the surfactant from the hydrophobic molecule, and analyzing said hydrophobic molecule.

Abstract: Cleavable compositions that comprise a polar head, cleavable linker, and a hydrophobic tail; and methods for using them to isolate hydrophobic molecules.

Abstract: A method of modifying protein samples that comprises combining the sample with a peroxycarbonate solution and inserting the sample into a mass spectrometer. The present invention also includes methods of N-terminus characterization.

Abstract: A device is described for pre-concentration and purification of analytes from biological samples (such as human serum, plasma, homogenized solid tissue, etc.) to be analyzed by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry (MALDI MS) and methods of use thereof are provided.

Abstract: The present invention provides methods for obtaining information of a plurality of target molecules by matrix free LDI MS. Mass tagged complexes for detection of target molecules comprise a target molecule binding domain, and a mass tag separated by a cleavable linker. Methods of the invention may be used for example to analyze the distribution of a multiple target molecules in a complex sample, such as a tissue section.

Abstract: Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins.

Abstract: Cleavable compositions and methods of use especially in MALDI MS analysis of hydrophobic proteins.