Abstract: A process for extracting a target compound from a biomass includes: extracting a compound from a biomass charge using supercritical or subcritical CO2 as a solvent, at a first pressure and a first temperature, to yield a compound-laden solvent stream, the compound-laden solvent stream including the solvent, a solubilized target compound, and a solubilized byproduct compound; changing the temperature while maintaining the first pressure of the compound-laden solvent stream to desolubilize the byproduct compound from the compound-laden solvent stream to yield a resultant stream containing the solvent, the solubilized target compound, and a desolubilized byproduct compound; passing the resultant stream through a filter medium to separate the desolubilized byproduct compound from the solubilized target compound; and collecting the solubilized target compound.